- Emergence and persistence of CXCR4-tropic HIV-1 in a population of men from the Multicenter AIDS Cohort Study
[作者:Shepherd, JC; Jacobson, LP; Qiao, W; Jamieson, BD; Phair, JP; Piazza, P; Quinn, TC; Margolick, JB,期刊:Journal of Infectious Diseases, 页码:1104-1112 , 文章类型: Article,,卷期:2008年198-8]
- We examined the emergence of CXCR4 (i.e., X4) tropism in 67 male human immunodeficiency virus type 1 (HIV-1) seroconverters from the Multicenter AIDS Cohort Study (MACS) who were selected to reflect the full spectrum of ...
- Phase II study of vicriviroc versus efavirenz (both with zidovudine/lamivudine) in treatment-naive subjects with HIV-1 infection
[作者:Landovitz, RJ; Angel, JB; Hoffmann, C; Horst, H; Opravil, M; Long, J; Greaves, W; Fatkenheuer, G,期刊:Journal of Infectious Diseases, 页码:1113-1122 , 文章类型: Article,,卷期:2008年198-8]
- Background. Vicriviroc (VCV) is a CCR5 antagonist with nanomolar activity against human immunodeficiency virus (HIV) replication in vitro and in vivo. We report the results of a phase II dose-finding study of VCV plus du...
- Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains
[作者:Shopsin, B; Drlica-Wagner, A; Mathema, B; Adhikari, RP; Kreiswirth, BN; Novick, RP,期刊:Journal of Infectious Diseases, 页码:1171-1174 , 文章类型: Article,,卷期:2008年198-8]
- Mutations in the staphylococcal virulence regulator gene agr frequently occur during Staphylococcus aureus infection. Whether agr-defective strains are fit for colonization, an important prerequisite for infection, is un...
- Functional gene polymorphisms in Canadian Aboriginal populations with high rates of tuberculosis
[作者:Larcombe, LA; Orr, PH; Lodge, AM; Brown, JS; Dembinski, IJ; Milligan, LC; Larcombe, EA; Martin, BD; Nickerson, PW,期刊:Journal of Infectious Diseases, 页码:1175-1179 , 文章类型: Article,,卷期:2008年198-8]
- The present study determined whether a pattern of functional single-nucleotide polymorphisms (SNPs) was present that could predispose a Dene cohort to a suboptimal response to Mycobacterium tuberculosis. Compared with a ...
- The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection
[作者:Tagliabue, C; Salvatore, CM; Techasaensiri, C; Mejias, A; Torres, JP; Katz, K; Gomez, AM; Esposito, S; Principi, N; Hardy, RD,期刊:Journal of Infectious Diseases, 页码:1180-1188 , 文章类型: Article,,卷期:2008年198-8]
- Background. Systemic steroids have been advocated in addition to antimicrobial therapy for severe Mycoplasma pneumoniae pneumonia. We evaluated the efficacy of clarithromycin, dexamethasone, and combination therapy for M...
- Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva
[作者:Hovius, JW; Schuijt, TJ; de Groot, KA; Roelofs, JJTH; Oei, GA; Marquart, JA; de Beer, R; Veer, CV'; van der Poll, T; Ramamoorthi, N; Fikrig, E; van Dam, AP,期刊:Journal of Infectious Diseases, 页码:1189-1197 , 文章类型: Article,,卷期:2008年198-8]
- Background. Ixodes ticks are the main vectors for Borrelia burgdorferi sensu lato. In the United States, B. burgdorferi is the sole causative agent of Lyme borreliosis and is transmitted by Ixodes scapularis. In Europe, ...
- Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa
[作者:Park, J; Kaufmann, GF; Bowen, JP; Arbiser, JL; Janda, KD,期刊:Journal of Infectious Diseases, 页码:1198-1201 , 文章类型: Article,,卷期:2008年198-8]
- In Pseudomonas aeruginosa, quorum-sensing (QS) signaling regulates the expression of virulence factors and thus represents an attractive new target for anti-infective therapy. In the present study, we investigated whethe...
- A randomized, controlled trial of intermittent preventive treatment with sulfadoxine-pyrimethamine, amodiaquine, or the combination in pregnant women in Ghana
[作者:Clerk, CA; Bruce, J; Affipunguh, PK; Mensah, N; Hodgson, A; Greenwood, B; Chandramohan, D,期刊:Journal of Infectious Diseases, 页码:1202-1211 , 文章类型: Article,,卷期:2008年198-8]
- Background. The use of sulfadoxine-pyrimethamine ( SP) for intermittent preventive treatment in pregnancy (IPTp) is threatened by the spread of resistance to SP. Therefore, we studied the efficacy, safety, and tolerance ...
- Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections
[作者:Murhandarwati, EEH; Black, CG; Wang, L; Weisman, S; de Koning-Ward, TF; Baird, JK; Tjitra, E; Richie, TL; Crabb, BS; Coppel, RL,期刊:Journal of Infectious Diseases, 页码:1212-1218 , 文章类型: Article,,卷期:2008年198-8]
- Antibodies against the 19 kDa C-terminal fragment of merozoite surface protein 1 (MSP1(19)) are a major component of the invasion-inhibitory response in individuals immune to malaria. We report here the acquisition of MS...
- Polymorphic variability in the interleukin (IL)-1 beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1 beta production
[作者:Ouma, C; Davenport, GC; Awandare, GA; Keller, CC; Were, T; Otieno, MF; Vulule, JM; Martinson, J; Ong'echa, JM; Ferrell, RE; Perkins, DJ,期刊:Journal of Infectious Diseases, 页码:1219-1226 , 文章类型: Article,,卷期:2008年198-8]
- Interleukin (IL)-1 beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1 beta polymorphic variability in conditioning the immunopathogenesis of severe...
- High heritability but uncertain mode of inheritance for total serum IgE level and schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
[作者:Grant, AV; Araujo, MI; Ponte, EV; Oliveira, RR; Cruz, AA; Barnes, KC; Beaty, TH,期刊:Journal of Infectious Diseases, 页码:1227-1236 , 文章类型: Article,,卷期:2008年198-8]
- Background. Evidence of genetic control for total serum IgE (tIgE) level has been reported in multiple populations, although populations with substantial exposure to helminths have yielded lower estimates of heritability...
- Repeated treatments with albendazole enhance Th2 responses to Ascaris lumbricoides, but not to aeroallergens, in children from rural communities in the tropics
[作者:Cooper, PJ; Moncayo, AL; Guadalupe, I; Benitez, S; Vaca, M; Chico, M; Griffin, GE,期刊:Journal of Infectious Diseases, 页码:1237-1242 , 文章类型: Article,,卷期:2008年198-8]
- Geohelminth infections are associated with modulation of immunity to parasite antigens and aeroallergens. To investigate the possibility that this modulation is affected by anthelmintic treatment, we compared cytokine re...
- Human platelets attenuate Aspergillus species via granule-dependent mechanisms
[作者:Perkhofer, S; Kehrel, BE; Dierich, MP; Donnelly, JP; Nussbaumer, W; Hofmann, J; von Eiff, C; Lass-Florl, C,期刊:Journal of Infectious Diseases, 页码:1243-1246 , 文章类型: Article,,卷期:2008年198-8]
- Using laser scanning microscopy, we investigated whether platelets are capable of internalizing Aspergillus conidia and examined Aspergillus-platelet adherence. The influence of platelets on fungal growth was evaluated b...
- Mannose-binding lectin concentrations, MBL2 polymorphisms, and susceptibility to respiratory tract infections in young men
[作者:Rantala, A; Lajunen, T; Juvonen, R; Bloigu, A; Silvennoinen-Kassinen, S; Peitso, A; Saikku, P; Vainio, O; Leinonen, M,期刊:Journal of Infectious Diseases, 页码:1247-1253 , 文章类型: Article,,卷期:2008年198-8]
- Background. Mannose-binding lectin (MBL) is an important component of innate immunity, and its deficiency is associated with susceptibility to recurrent infections.Methods. This exploratory study investigated the associa...
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