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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   Design, synthesis, and subtype selectivity of 3,6-disubstituted beta-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse [作者：YIN WENYUAN; MAJUMDER SAMARPAN; CLAYTON TERRY; PETROU STEVEN; VANLINN MICHAEL L; NAMJOSHI OJAS A; MA CHUNRONG; CROMER BRETT A; ROTH BRYAN L; PLATT DONNA M; COOK JAMES M,期刊：Bioorganic & Medicinal Chemistry, 页码：7548-7564 , 文章类型： Article，,卷期：2010年18-21] A series of 3,6-disubstituted beta-carbolines was synthesized and evaluated for their in vitro affinities at alpha(x)beta(3)gamma(2) GABA(A)/benzodiazepine receptor subtypes by radioligand binding assays in search of alp... Synthesis, NMR characterization and divergent biological actions of 2 '-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells [作者：SZULC ZDZISLAW M; BAI AIPING; BIELAWSKI JACEK; MAYROO NALINI; MILLER DOREEN E; GRACZ HANNA; HANNUN YUSUF A; BIELAWSKA ALICJA,期刊：Bioorganic & Medicinal Chemistry, 页码：7565-7579 , 文章类型： Article，,卷期：2010年18-21] A straightforward method for the simultaneous preparation of (2S, 3R, 2'R)-and (2S, 3R, 2'S)-2'-hydroxyceramides (2'-OHCer) from (2S, 3R)-sphingosine acetonide precursors and racemic mixtures of 2-hydroxy fatty acids (2-... Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors [作者：SONG HYUNMIN; OH SEIRYANG; LEE HYEONGKYU; HAN GYOONHEE; KIM JOOHEON; CHANG HYEUN WOOK; DOH KYUNGEUN; RHEE HEEKYUNG; CHOO HEAYOUNG PARK,期刊：Bioorganic & Medicinal Chemistry, 页码：7580-7585 , 文章类型： Article，,卷期：2010年18-21] 5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as... A histone deacetylase-dependent screen in yeast [作者：WEERASINGHE SUJITH V W; WAMBUA MAGDALENE; PFLUM MARY KAY H,期刊：Bioorganic & Medicinal Chemistry, 页码：7586-7592 , 文章类型： Article，,卷期：2010年18-21] Histone deacetylase ( HDAC) proteins are promising targets for cancer treatment, as shown by the recent FDA approval of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA, Vorinostat) for the treatment of cutaneous... 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of beta-1,6-glucan synthesis inhibitors [作者：KUROYANAGI JUNICHI; KANAI KAZUO; SUGIMOTO YUUICHI; HORIUCHI TAKAO; ACHIWA ISSEI; TAKESHITA HIROSHI; KAWAKAMI KATSUHIRO,期刊：Bioorganic & Medicinal Chemistry, 页码：7593-7606 , 文章类型： Article，,卷期：2010年18-21] Synthesis and in vitro antifungal evaluations of 1,3-benzoxazole-7-carbonitrile 3, 1,3-benzoxazole-4-carbonitrile 4, benzofuran 5, benzoxazine 7, and benzimidazole 8 were reported. Among them, 1,3-benzoxazole-4-carbonitr... Binding of diarrheic shellfish poisoning toxins to okadaic acid binding proteins purified from the sponge Halichondria okadai [作者：KONOKI KEIICHI; SAITO KAORI; MATSUURA HIROKI; SUGIYAMA NAOYUKI; CHO YUKO; YOTSUYAMASHITA MARI; TACHIBANA KAZUO,期刊：Bioorganic & Medicinal Chemistry, 页码：7607-7610 , 文章类型： Article，,卷期：2010年18-21] Okadaic acid (OA) and dinophysistoxin-1 (DTX1) cause diarrheic shellfish poisoning. This article examines the biochemical interactions of the two toxins with novel okadaic acid binding proteins (OABPs) 2.1 and 2.3, origi... Small molecule peptidomimetic inhibitors of importin alpha/beta mediated nuclear transport [作者：AMBRUS GEZA; WHITBY LANDON R; SINGER ERIC L; TROTT OLEG; CHOI EUNA; OLSON ARTHUR J; BOGER DALE L; GERACE LARRY,期刊：Bioorganic & Medicinal Chemistry, 页码：7611-7620 , 文章类型： Article，,卷期：2010年18-21] Nucleocytoplasmic transport of macromolecules is a fundamental process of eukaryotic cells. Translocation of proteins and many RNAs between the nucleus and cytoplasm is carried out by shuttling receptors of the beta-kary... The synthesis and biologic evaluation of anti-platelet and cytotoxic beta-nitrostyrenes [作者：HSIEH PEIWEN; CHANG YUTING; CHUANG WEN YIN; SHIH HSINCHU; CHIANG SHINZAN; WU CHINCHUNG,期刊：Bioorganic & Medicinal Chemistry, 页码：7621-7627 , 文章类型： Article，,卷期：2010年18-21] Our previous studies demonstrated that two cytotoxic beta-nitrostyrene derivatives, 3,4-methylenedioxy-beta-nitrostyrene (MNS) and 4-O-benzoyl-3-methoxy-beta-nitrostyrene (BMNS) exhibit potent anti-platelet activities. I... Design, synthesis, and evaluation of an alpha-tocopherol analogue as a mitochondrial antioxidant [作者：LU JUN; KHDOUR OMAR M; ARMSTRONG JEFFREY S; HECHT SIDNEY M,期刊：Bioorganic & Medicinal Chemistry, 页码：7628-7638 , 文章类型： Article，,卷期：2010年18-21] An efficient synthesis has provided access to a novel alpha-tocopherol analogue (2), as well as its trifluoroacetate salt and acetate ester. An annulation reaction was used to establish the pyridinol core structure and a... A convenient synthesis and molecular modeling study of novel purine and pyrimidine derivatives as CDK2/cyclin A3 inhibitors [作者：ELGAZWY ABDELSATTAR S HAMAD; ISMAIL NASSER S M; ELZAHABI HEBA S A,期刊：Bioorganic & Medicinal Chemistry, 页码：7639-7650 , 文章类型： Article，,卷期：2010年18-21] A series of novel purine and pyrimidine derivatives were prepared and biologically evaluated for their in vitro anti-CDK2/cyclin A3 and antitumor activities in Ehrlich ascites carcinoma (EAC) cell based assay. The novel ... 9-Dihydroerythromycin ethers as motilin agonists-Developing structure-activity relationships for potency and safety [作者：LIU YAOQUAN; LI YONG; MYLES DAVID C; CLAYPOOL MARK; CARRERAS CHRISTOPHER W; SHAW SIMON J,期刊：Bioorganic & Medicinal Chemistry, 页码：7651-7658 , 文章类型： Article，,卷期：2010年18-21] A series of derivatives of the amine of 9-dihydro-9-O-ethylamino-N-desmethyl-N-isopropyl erythromycin A derivatives were synthesized as motilin agonists. The compounds were developed for potency without showing antibacte... 3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT) [作者：KOVAC MITJA; MAVEL SYLVIE; DEUTHERCONRAD WINNIE; MEHEUX NATHALIE; GLOECKNER JANA; WENZEL BARBARA; ANDERLUH MARKO; BRUST PETER; GUILLOTEAU DENIS; EMOND PATRICK,期刊：Bioorganic & Medicinal Chemistry, 页码：7659-7667 , 文章类型： Article，,卷期：2010年18-21] Located in presynaptic cholinergic nerve terminals, the vesicular acetylcholine transporter (VAChT) represents a potential target for quantitative visualization of early degeneration of cholinergic neurons in Alzheimer's... In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis [作者：KWON HYUNGJUN; KIM HAHYUN; RYU YOUNG BAE; KIM JANG HOON; JEONG HYUNG JAE; LEE SEUNGWOONG; CHANG JONG SUN; CHO KYOUNGOH; RHO MUNCHUAL; PARK SUJIN; LEE WOO SONG,期刊：Bioorganic & Medicinal Chemistry, 页码：7668-7674 , 文章类型： Article，,卷期：2010年18-21] We evaluated the ability of six polyphenols isolated from the roots of Glycyrrhiza uralensis to inactivate rotaviruses, specially G5P[7] and G8P[7]. Upon finding that all polyphenols possessed anti-rotavirus activity, we... Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: Design, synthesis, and structure-activity relationships [作者：HAYASHI SHIGEO; NAKATA ERIKO; MORITA ASATO; MIZUNO KUNIHIKO; YAMAMURA KENZO; KATO AKI; OHASHI KATSUYO,期刊：Bioorganic & Medicinal Chemistry, 页码：7675-7699 , 文章类型： Article，,卷期：2010年18-21] Neuropathic pain is a serious chronic disorder caused by lesion or dysfunction in the nervous systems. Endogenous nociceptin/orphanin FQ (N/OFQ) peptide and N/OFQ peptide (NOP) receptor [or opioidreceptor-like-1 (ORL1) r... Identification of novel antitubercular compounds through hybrid virtual screening approach (vol 18, pg 6914, 2010) [作者：MUDDASSAR MUHAMMAD; JANG JAE WAN; HONG SEUNG KON; CHO YONG SEO; KIM EUNICE EUNKYUNG; KEUM KYO CHANG; OH TAEGWON; CHO SANGNAE; PAE AE NIM,期刊：Bioorganic & Medicinal Chemistry, 页码：7700-7700 , 文章类型： Correction，,卷期：2010年18-21] 3-O-Arylmethylgalangin, a novel isostere for anti-HCV 1,3-diketoacids (DKAs) [作者：LEE HYO SEON; PARK KWANGSU; LEE BOKHUI; KIM DONGEUN; CHONG YOUHOON,期刊：Bioorganic & Medicinal Chemistry, 页码：7331-7337 , 文章类型： Article，,卷期：2010年18-21] Through chelation of the metal ions at the enzyme active site, 1,3-diketoacids (DKAs) show potent inhibition of viral enzymes such as HIV integrase and HCV NS5B. In order to optimize the antiviral activity of the DKAs, s...