- DNA Damage Signals through Differentially Modified E2F1 Molecules To Induce Apoptosis
[作者:Carnevale, J; Palander, O; Seifried, LA; Dick, FA,期刊:Molecular and Cellular Biology, 页码:900-912 , 文章类型: Article,,卷期:2012年32-5]
- E2F transcription can lead to cell proliferation or apoptosis, indicating that E2Fs control opposing functions. In a similar manner, DNA double-strand breaks can signal to induce cell cycle arrest or apoptosis. Specifica...
- AU-Rich-Element-Dependent Translation Repression Requires the Cooperation of Tristetraprolin and RCK/P54
[作者:Qi, MY; Wang, ZZ; Zhang, Z; Shao, Q; Zeng, A; Li, XQ; Li, WQ; Wang, C; Tian, FJ; Li, Q; Zou, J; Qin, YW; Brewer, G; Huang, S; Jing, Q,期刊:Molecular and Cellular Biology, 页码:913-928 , 文章类型: Article,,卷期:2012年32-5]
- AU-rich elements (AREs), residing in the 3' untranslated region (UTR) of many labile mRNAs, are important cis-acting elements that modulate the stability of these mRNAs by collaborating with trans-acting factors such as ...
- Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR
[作者:Gabai, VL; Meng, L; Kim, G; Mills, TA; Benjamin, IJ; Sherman, MY,期刊:Molecular and Cellular Biology, 页码:929-940 , 文章类型: Article,,卷期:2012年32-5]
- Previously we demonstrated that the heat shock transcription factor Hsf1 is indispensable for transformation of mammary epithelial cells by the Her2 oncogene. Since Hsf1 affects oncogene-induced senescence (OIS), these f...
- Critical and Reciprocal Regulation of KLF4 and SLUG in Transforming Growth Factor beta-Initiated Prostate Cancer Epithelial-Mesenchymal Transition
[作者:Liu, YN; Abou-Kheir, W; Yin, JJ; Fang, L; Hynes, P; Casey, O; Hu, D; Wan, Y; Seng, V; Sheppard-Tillman, H; Martin, P; Kelly, K,期刊:Molecular and Cellular Biology, 页码:941-953 , 文章类型: Article,,卷期:2012年32-5]
- Epithelial-mesenchymal transition (EMT) is implicated in various pathological processes within the prostate, including benign prostate hyperplasia (BPH) and prostate cancer progression. However, an ordered sequence of si...
- Proteins Associated with the Exon Junction Complex Also Control the Alternative Splicing of Apoptotic Regulators
[作者:Michelle, L; Cloutier, A; Toutant, J; Shkreta, L; Thibault, P; Durand, M; Garneau, D; Gendron, D; Lapointe, E; Couture, S; Le Hir, H; Klinck, R; Abou Elela, S; Prinos, P; Chabot, B,期刊:Molecular and Cellular Biology, 页码:954-967 , 文章类型: Article,,卷期:2012年32-5]
- Several apoptotic regulators, including Bcl-x, are alternatively spliced to produce isoforms with opposite functions. We have used an RNA interference strategy to map the regulatory landscape controlling the expression o...
- A Novel Feedback Loop Regulates the Response to Endoplasmic Reticulum Stress via the Cooperation of Cytoplasmic Splicing and mRNA Translation
[作者:Majumder, M; Huang, C; Snider, MD; Komar, AA; Tanaka, J; Kaufman, RJ; Krokowski, D; Hatzoglou, M,期刊:Molecular and Cellular Biology, 页码:992-1003 , 文章类型: Article,,卷期:2012年32-5]
- The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers transcriptional and translational reprogramming. This unfolded protein response (UPR) protects cells during transient stress and can lead t...
- A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)-p85 to Filamin A Negatively Controls the PI3K Pathway
[作者:Najib, S; Saint-Laurent, N; Esteve, JP; Schulz, S; Boutet-Robinet, E; Fourmy, D; Lattig, J; Mollereau, C; Pyronnet, S; Susini, C; Bousquet, C,期刊:Molecular and Cellular Biology, 页码:1004-1016 , 文章类型: Article,,卷期:2012年32-5]
- Frequent oncogenic alterations occur in the phosphoinositide 3-kinase (PI3K) pathway, urging identification of novel negative controls. We previously reported an original mechanism for restraining PI3K activity, controll...
- New Mutations at the Imprinted Gnas Cluster Show Gene Dosage Effects of Gs alpha in Postnatal Growth and Implicate XL alpha s in Bone and Fat Metabolism but Not in Suckling
[作者:Eaton, SA; Williamson, CM; Ball, ST; Beechey, CV; Moir, L; Edwards, J; Teboul, L; Maconochie, M; Peters, J,期刊:Molecular and Cellular Biology, 页码:1017-1029 , 文章类型: Article,,卷期:2012年32-5]
- The imprinted Gnas cluster is involved in obesity, energy metabolism, feeding behavior, and viability. Relative contribution of paternally expressed proteins XL alpha s, XLN1, and ALEX or a double dose of maternally expr...
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