- Molecular and Cellular Targets of the MRI Contrast Agent P947 for Atherosclerosis Imaging
[作者：Ouimet, T; Lancelot, E; Hyafil, F; Rienzo, M; Deux, F; Lemaitre, M; Duquesnoy, S; Garot, J; Roques, BP; Michel, JB; Corot, C; Ballet, S,期刊：Molecular Pharmaceutics, 页码：850-861 , 文章类型： Article，,卷期：2012年9-4]
- P947 (DOTA-Gd-peptide) was recently identified as an MRI contrast agent for the detection and characterization of the matrix metalloproteinases (MMP)rich atherosclerotic plaques. Because this product displays a broad spe...
- SULT1A3-Mediated Regiospecific 7-O-Sulfation of Flavonoids in Caco-2 Cells Can Be Explained by the Relevant Molecular Docking Studies
[作者：Meng, SN; Wu, BJ; Singh, R; Yin, TJ; Morrow, JK; Zhang, SX; Hu, M,期刊：Molecular Pharmaceutics, 页码：862-873 , 文章类型： Article，,卷期：2012年9-4]
- Flavonoids are polyphenolic compounds with various claimed health benefits, but the extensive metabolism by uridine-S'diphospho-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) in liver and intestine led to ...
- Amphiphilic Polyanhydride Nanoparticles Stabilize Bacillus anthracis Protective Antigen
[作者：Petersen, LK; Phanse, Y; Ramer-Tait, AE; Wannemuehler, MJ; Narasimhan, B,期刊：Molecular Pharmaceutics, 页码：874-882 , 文章类型： Article，,卷期：2012年9-4]
- Advancements toward an improved vaccine against Bacillus anthracis, the causative agent of anthrax, have focused on formulations composed of the protective antigen (PA) adsorbed to aluminum hydroxide. However, due to the...
- The Involvement of a Na+- and Cl--Dependent Transporter in the Brain Uptake of Amantadine and Rimantadine
[作者：Kooijmans, SAA; Senyschyn, D; Mezhiselvam, MM; Morizzi, J; Charman, SA; Weksler, B; Romero, IA; Couraud, PO; Nicolazzo, JA,期刊：Molecular Pharmaceutics, 页码：883-893 , 文章类型： Article，,卷期：2012年9-4]
- Despite their structural similarity, the two anti-influenza adamantane compounds amantadine (AMA) and rimantadine (RIM) exhibit strikingly different rates of blood-brain barrier (BBB) transport. However, the molecular me...
- Enhancement of Amorphous Celecoxib Stability by Mixing It with Octaacetylrnaltose: The Molecular Dynamics Study
[作者：Grzybowska, K; Paluch, M; Wlodarczyk, P; Grzybowski, A; Kaminski, K; Hawelek, L; Zakowiecki, D; Kasprzycka, A; Jankowska-Sumara, I,期刊：Molecular Pharmaceutics, 页码：894-904 , 文章类型： Article，,卷期：2012年9-4]
- In this paper, we present a novel way of stabilization of amorphous celecoxib (CEL) against recrystallization by preparing binary amorphous celecoxib-octaacetylmaltose (CEL-acMAL) systems by quench-cooling of the molten ...
- Exploiting Evolution To Treat Drug Resistance: Combination Therapy and the Double Bind
[作者：Basanta, D; Gatenby, RA; Anderson, ARA,期刊：Molecular Pharmaceutics, 页码：914-921 , 文章类型： Article，,卷期：2012年9-4]
- Although many anticancer therapies are successful in killing a large percentage of tumor cells when initially administered, the evolutionary dynamics underpinning tumor progression mean that, often, resistance is an inev...
- Involvement of Functional Groups on the Surface of Carboxyl Group-Terminated Polyamidoamine Dendrimers Bearing Arbutin in Inhibition of Na+/Glucose Cotransporter 1 (SGLT1)-Mediated D-Glucose Uptake
[作者：Sakuma, S; Kanamitsu, S; Teraoka, Y; Masaoka, Y; Kataoka, M; Yamashita, S; Shirasaka, Y; Tamai, I; Muraoka, M; Nakatsuji, Y; Kida, T; Akashi, M,期刊：Molecular Pharmaceutics, 页码：922-929 , 文章类型： Article，,卷期：2012年9-4]
- A carboxyl group-terminated polyamidoamine dendrimer (generation: 3.0) bearing arbutin, which is a substrate of Ne+/glucose cotransporter 1 (SGLT1), via a nonbiodegradable omega-amino triethylene glycol linker (PAMAM-ARB...
- Raman Microscopy for Noninvasive Imaging of Pharmaceutical Nanocarriers: Intracellular Distribution of Cationic Liposomes of Different Composition
[作者：Chernenko, T; Sawant, RR; Miljkovic, M; Quintero, L; Diem, M; Torchilin, V,期刊：Molecular Pharmaceutics, 页码：930-936 , 文章类型： Article，,卷期：2012年9-4]
- Nanotechnology is playing an increasing role in targeted drug delivery into pathological tissues. Drug-loaded pharmaceutical nanocarriers can be delivered into diseased sites by passive targeting (spontaneous accumulatio...
- Mucoadhesive Fenretinide Patches for Site-Specific Chemoprevention of Oral Cancer: Enhancement of Oral Mucosal Permeation of Fenretinide by Coincorporation of Propylene Glycol and Menthol
[作者：Wu, X; Desai, KGH; Mallery, SR; Holpuch, AS; Phelps, MP; Schwendeman, SP,期刊：Molecular Pharmaceutics, 页码：937-945 , 文章类型： Article，,卷期：2012年9-4]
- The objective of this study was to enhance oral mucosal permeation of fenretinide by coincorporation of propylene glycol (PG) and menthol in fenretinide/Eudragit RL PO mucoadhesive patches. Fenretinide is an extremely hy...
- Zidovudine and Ursodeoxycholic Acid Conjugation: Design of a New Prodrug Potentially Able To Bypass the Active Efflux Transport Systems of the Central Nervous System
[作者：Dalpiaz, A; Paganetto, G; Pavan, B; Fogagnolo, M; Medici, A; Beggiato, S; Perrone, D,期刊：Molecular Pharmaceutics, 页码：957-968 , 文章类型： Article，,卷期：2012年9-4]
- We have synthesized a new prodrug obtained by the 5'-ester conjugation of zidovudine (AZT), an antiviral agent substrate of active efflux transport systems (AET), with ursodeoxycholic acid (UDCA), a bile acid able to per...
- An Antidote for Acute Cocaine Toxicity
[作者：Treweek, JB; Janda, KD,期刊：Molecular Pharmaceutics, 页码：969-978 , 文章类型： Article，,卷期：2012年9-4]
- Not only has immunopharmacotherapy grown into a field that addresses the abuse of numerous illicit substances, but also the treatment methodologies within immunopharmacotherapy have expanded from traditional active vacci...
- Vaccine-like Controlled-Release Delivery of an Immunomodulating Peptide To Treat Experimental Autoimmune Encephalomyelitis
[作者：Buyuktimkin, B; Wang, Q; Kiptoo, P; Stewart, JM; Berkland, C; Siahaan, TJ,期刊：Molecular Pharmaceutics, 页码：979-985 , 文章类型： Article，,卷期：2012年9-4]
- The objective of this work is to use colloidal gel from alginate-chitosan-PLGA complex to deliver Ac-PLP-BPI-NH2-2 peptide in a controlled-release manner as a vaccine-like therapeutic to suppress experimental autoimmune ...
- Interaction of Three Regiospecific Amino Acid Residues Is Required for OATP1B1 Gain of OATP1B3 Substrate Specificity
[作者：DeGorter, MK; Ho, RH; Leake, BF; Tirona, RG; Kim, RB,期刊：Molecular Pharmaceutics, 页码：986-995 , 文章类型： Article，,卷期：2012年9-4]
- The human organic anion-transporting polypeptides OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3) are liver-enriched membrane transporters of major importance to hepatic uptake of numerous endogenous compounds, including bile ac...
- ADMET Evaluation in Drug Discovery. 12. Development of Binary Classification Models for Prediction of hERG Potassium Channel Blockage
[作者：Wang, SC; Li, YY; Wang, JM; Chen, L; Zhang, LL; Yu, HD; Hou, TJ,期刊：Molecular Pharmaceutics, 页码：996-1010 , 文章类型： Article，,卷期：2012年9-4]
- Inhibition of the human ether-a-go-go related gene (hERG) potassium channel may result in QT interval prolongation, which causes severe cardiac side effects and is a major problem in clinical studies of drug candidates. ...
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