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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共15条记录   SPANosomes as Delivery Vehicles for Small Interfering RNA (siRNA) [作者：Zhou, CG; Mao, YC; Sugimoto, Y; Zhang, Y; Kanthamneni, N; Yu, B; Brueggemeier, RW; Lee, LJ; Lee, RJ,期刊：Molecular Pharmaceutics, 页码：201-210 , 文章类型： Article，,卷期：2012年9-2] Nonionic surfactant vesicles, or SPANosomes (SPs), comprised of cationic lipid and sorbitan monooleate (Span 80) were synthesized and evaluated as small interfering RNA (siRNA) vectors. The SPs had a mean diameter of les... The Natural Cell-Penetrating Peptide Crotamine Targets Tumor Tissue in Vivo and Triggers a Lethal Calcium-Dependent Pathway in Cultured Cells [作者：Nascimento, FD; Sancey, L; Pereira, A; Rome, C; Oliveira, V; Oliveira, EB; Nader, HB; Yamane, T; Kerkis, I; Tersariol, ILS; Coll, JL; Hayashi, MAF,期刊：Molecular Pharmaceutics, 页码：211-221 , 文章类型： Article，,卷期：2012年9-2] Our goal was to demonstrate the in vivo tumor specific accumulation of crotamine, a natural peptide from the venom of the South American rattlesnake Crotalus durissus terrificus, which has been characterized by our group... Paclitaxel/Tetrandrine Coloaded Nanoparticles Effectively Promote the Apoptosis of Gastric Cancer Cells Based on "Oxidation Therapy" [作者：Li, XL; Lu, XW; Xu, HE; Zhu, ZS; Yin, HT; Qian, XP; Li, RT; Jiang, XQ; Liu, BR,期刊：Molecular Pharmaceutics, 页码：222-229 , 文章类型： Article，,卷期：2012年9-2] Paclitaxel (Ptx) has demonstrated encouraging activity in the treatment of gastric cancer. Development of drug-containing biodegradable polymeric nanoparticles (np) becomes one of the solutions to relieve side effects of... Enhancement of the Targeting Capabilities of the Paclitaxel-Loaded Pluronic Nanoparticles with a Glycol Chitosan/Heparin Composite [作者：Yuk, SH; Oh, KS; Cho, SH; Kim, SY; Oh, S; Lee, JH; Kim, K; Kwon, IC,期刊：Molecular Pharmaceutics, 页码：230-236 , 文章类型： Article，,卷期：2012年9-2] An enhancement of tumor-targeting capability was demonstrated with paclitaxel (PTX)-loaded Pluronic nanoparticles (NPs) with immobilized glycol chitosan and heparin. The PTX-loaded Pluronic NPs were prepared as described... Insights into Intermediate Phases of Human Intestinal Fluids Visualized by Atomic Force Microscopy and Cryo-Transmission Electron Microscopy ex Vivo [作者：Mullertz, A; Fatouros, DG; Smith, JR; Vertzoni, M; Reppas, C,期刊：Molecular Pharmaceutics, 页码：237-247 , 文章类型： Article，,卷期：2012年9-2] The current work aims to study at the ultrastructural level the morphological development of colloidal intermediate phases of human intestinal fluids (HIFs) produced during lipid digestion. HIFs were aspirated near the l... Copolymer Micelles and Nanospheres with Different In Vitro Stability Demonstrate Similar Paclitaxel Pharmacokinetics [作者：Letchford, K; Burt, HM,期刊：Molecular Pharmaceutics, 页码：248-260 , 文章类型： Article，,卷期：2012年9-2] Paclitaxel loaded amphiphilic block copolymer nanoparticles have been demonstrated to enhance the aqueous solubility and improve the toxicity profile as compared to the commercially available product Taxol; however, in m... Trp2 Peptide Vaccine Adjuvanted with (R)-DOTAP Inhibits Tumor Growth in an Advanced Melanoma Model [作者：Vasievich, EA; Ramishetti, S; Zhang, Y; Huang, L,期刊：Molecular Pharmaceutics, 页码：261-268 , 文章类型： Article，,卷期：2012年9-2] Previously we have shown cationic lipid (R)-DOTAP as the immunologically active enantiomer of the DOTAP racemic mixture, initiating complete tumor regression in an exogenous antigen model (murine cervical cancer model). ... Controlled Release Pulmonary Administration of Curcumin Using Swellable Biocompatible Microparticles [作者：E-Sherbiny, IM; Smyth, HDC,期刊：Molecular Pharmaceutics, 页码：269-280 , 文章类型： Article，,卷期：2012年9-2] This study involves a promising approach to achieve sustained pulmonary drug delivery. Dry powder particulate carriers were engineered to allow simultaneous aerosol lung delivery, evasion of macrophage uptake, and sustai... Oligoclonal Antibody Targeting Ghrelin Increases Energy Expenditure and Reduces Food Intake in Fasted Mice [作者：Zakhari, JS; Zorrilla, EP; Zhou, B; Mayorov, AV; Janda, KD,期刊：Molecular Pharmaceutics, 页码：281-289 , 文章类型： Article，,卷期：2012年9-2] Ghrelin, an enteric peptide hormone linked to the pathophysiology of obesity has been a therapeutic target of great interest over the past decade. Many research efforts have focused on the antagonism of ghrelin's endogen... Synthesis, Optimization, and Characterization of Camptothecin-Loaded Acetalated Dextran Porous Microparticles for Pulmonary Delivery [作者：Meenach, SA; Kim, YJ; Kauffman, KJ; Kanthamneni, N; Bachelder, EM; Ainslie, KM,期刊：Molecular Pharmaceutics, 页码：290-298 , 文章类型： Article，,卷期：2012年9-2] We propose the use of a new biopolymer, acetalated dextran (Ac-DEX), to synthesize porous microparticles for pulmonary drug delivery. Ac-DEX is derived from the polysaccharide dextran and, unlike polyesters, has tunable ... Comparison of Cationic and Amphipathic Cell Penetrating Peptides for siRNA Delivery and Efficacy [作者：Mo, RH; Zaro, JL; Shen, WC,期刊：Molecular Pharmaceutics, 页码：299-309 , 文章类型： Article，,卷期：2012年9-2] Cell penetrating peptides (CPPs) are short strands of arginine- and/or lysine-rich peptides (<30 amino acids) that use their cationic nature for efficient intracellular accumulation. CPPs have been used for small interfe... Characterization of in Vivo Disulfide-Reduction Mediated Drug Release in Mouse Kidneys [作者：Yang, JJ; Kularatne, SA; Chen, XM; Low, PS; Wang, E,期刊：Molecular Pharmaceutics, 页码：310-317 , 文章类型： Article，,卷期：2012年9-2] Due to the overexpression of a folate receptor (FR) on many malignant cells, folate-targeted drugs have been developed to improve the cancer specificity of chemotherapeutic agents. Therapeutic index is further enhanced w... Probing Influence of Mesophasic Transformation on Performance of Self-Emulsifying System: Effect of Ion [作者：Patil, SS; Venugopal, E; Bhat, S; Mahadik, KR; Paradkar, AR,期刊：Molecular Pharmaceutics, 页码：318-324 , 文章类型： Article，,卷期：2012年9-2] Self-emulsifying systems are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the ga... Specific Inhibition of the Transcription Factor Ci by a Cobalt(III) Schiff Base-DNA Conjugate [作者：Hurtado, RR; Harney, AS; Heffern, MC; Holbrook, RJ; Holmgren, RA; Meade, TJ,期刊：Molecular Pharmaceutics, 页码：325-333 , 文章类型： Article，,卷期：2012年9-2] We describe the use of Co(III) Schiff base-DNA conjugates, a versatile class of research tools that target C2H2 transcription factors, to inhibit the Hedgehog (Hh) pathway. In developing mammalian embryos, Hh signaling i... Cholesterol-Dependent Macropinocytosis and Endosomal Escape Control the Transfection Efficiency of Lipoplexes in CHO Living Cells [作者：Cardarelli, F; Pozzi, D; Bifone, A; Marchini, C; Caracciolo, G,期刊：Molecular Pharmaceutics, 页码：334-340 , 文章类型： Article，,卷期：2012年9-2] Here we investigate the cellular uptake mechanism and final intracellular fate of two cationic liposome formulations characterized by similar physicochemical properties but very different lipid composition and efficiency...