- A Novel Naturally Occurring Salicylic Acid Analogue Acts as an Anti-Inflammatory Agent by Inhibiting Nuclear Factor-kappaB Activity in RAW264.7 Macrophages
[作者：Zhang, TT; Sun, L; Liu, R; Zhang, D; Lan, X; Huang, C; Xin, WY; Wang, C; Zhang, DM; Du, G,期刊：Molecular Pharmaceutics, 页码：671-677 , 文章类型： Article，,卷期：2012年9-3]
- Methyl salicylate 2-O-beta-D-lactoside (DL0309), is a molecule chemically related to salicylic acid that is isolated from Gaultheria yunnanensis (FRANCH.) REHDER (G. yunnanensis). G. yunnanensis, a traditional Chinese he...
- Detection of Endogenous K-ras mRNA in Living Cells at a Single Base Resolution by a PNA Molecular Beacon
[作者：Kam, Y; Rubinstein, A; Nissan, A; Halle, D; Yavin, E,期刊：Molecular Pharmaceutics, 页码：685-693 , 文章类型： Article，,卷期：2012年9-3]
- Detection of mRNA alterations is a promising approach for identifying biomarkers as means of differentiating benign from malignant lesions. By choosing the KRAS oncogene as a target gene, two types of molecular beacons (...
- Association of Chemotherapeutic Drugs with Dendrimer Nanocarriers: An Assessment of the Merits of Covalent Conjugation Compared to Noncovalent Encapsulation
[作者：Kaminskas, LM; McLeod, VM; Porter, CJH; Boyd, BJ,期刊：Molecular Pharmaceutics, 页码：355-373 , 文章类型： Review，,卷期：2012年9-3]
- Cancer is a leading cause of death within developed nations, and part of this morbidity is due to difficulties associated with its treatment. Currently, anticancer therapy relies heavily upon the administration of small ...
- Preparation of Cystamine Core Dendrimer and Antibody-Dendrimer Conjugates for MRI Angiography
[作者：Nwe, K; Milenic, DE; Ray, GL; Kim, YS; Brechbiel, MW,期刊：Molecular Pharmaceutics, 页码：374-381 , 文章类型： Article，,卷期：2012年9-3]
- Herein we report the preparation along with the in vivo and in vitro MRI characterization of two generation four and five cystamine core dendrimers loaded with thirty and fifty-eight derivatized Gd-DOTA (G4SS30, GSSS58) ...
- Nanoparticle Size and Surface Charge Determine Effects of PAMAM Dendrimers on Human Platelets in Vitro
[作者：Dobrovolskaia, MA; Patri, AK; Simak, J; Hall, JB; Semberova, J; Lacerda, SHDP; McNeil, SE,期刊：Molecular Pharmaceutics, 页码：382-393 , 文章类型： Article，,卷期：2012年9-3]
- Blood platelets are essential in maintaining hemostasis. Various materials can activate platelets and cause them to aggregate. Platelet aggregation in vitro is often used as a marker for materials thrombogenic properties...
- Antitumor Activity and Molecular Dynamics Simulations of Paclitaxel-Laden Triazine Dendrimers
[作者：Lim, J; Lo, ST; Hill, S; Pavan, GM; Sun, XK; Simanek, EE,期刊：Molecular Pharmaceutics, 页码：404-412 , 文章类型： Article，,卷期：2012年9-3]
- The antitumor activities of triazine dendrimers bearing paclitaxel, a well-known mitotic inhibitor, are evaluated in SCID mice bearing human prostate cancer xenografts. To increase the activity of a first generation prod...
- Doxorubicin-Conjugated PEGylated Dendrimers Show Similar Tumoricidal Activity but Lower Systemic Toxicity When Compared to PEGylated Liposome and Solution Formulations in Mouse and Rat Tumor Models
[作者：Kaminskas, LM; McLeod, VM; Kelly, BD; Cullinane, C; Sberna, G; Williamson, M; Boyd, BJ; Owen, DJ; Porter, CJH,期刊：Molecular Pharmaceutics, 页码：422-432 , 文章类型： Article，,卷期：2012年9-3]
- PEGylated polylysine dendrimers show promise as novel drug delivery systems with the potential to direct site specific deposition patterns and to reduce toxicity at nontarget sites. Here the activity and toxicity profile...
- Synthesis of Cationic Carbosilane Dendrimers via Click Chemistry and Their Use as Effective Carriers for DNA Transfection into Cancerous Cells
[作者：Arnaiz, E; Doucede, LI; Garcia-Gallego, S; Urbiola, K; Gomez, R; de Ilarduya, CT; de la Mata, FJ,期刊：Molecular Pharmaceutics, 页码：433-447 , 文章类型： Article，,卷期：2012年9-3]
- New amine-terminated carbosilane dendrimers have been prepared by a Huisgen cycloaddition ("click chemistry" reaction) of azide-terminated carbosilane dendrimers with two different propargyl amines. The corresponding cat...
- Biological Properties of New Viologen-Phosphorus Dendrimers
[作者：Ciepluch, K; Katir, N; El Kadib, A; Felczak, A; Zawadzka, K; Weber, M; Klajnert, B; Lisowska, K; Caminade, AM; Bousmina, M; Bryszewska, M; Majoral, JP,期刊：Molecular Pharmaceutics, 页码：448-457 , 文章类型： Article，,卷期：2012年9-3]
- Some biological properties of eight dendrimers incorporating both phosphorus linkages and viologen units within their cascade structure or at the periphery were investigated for the first time. In particular cytotoxicity...
- Phosphorus Dendrimers Affect Alzheimer's (A beta(1-28)) Peptide and MAP-Tau Protein Aggregation
[作者：Wasiak, T; Ionov, M; Nieznanski, K; Nieznanska, H; Klementieva, O; Granell, M; Cladera, J; Majoral, JP; Caminade, AM; Klajnert, B,期刊：Molecular Pharmaceutics, 页码：458-469 , 文章类型： Article，,卷期：2012年9-3]
- Alzheimer's disease (AD) is characterized by pathological aggregation of beta-amyloid peptides and MAP-Tau protein. beta-Amyloid (A beta) is a peptide responsible for extracellular Alzheimer's plaque formation. Intracell...
- Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer
[作者：Liu, XX; Liu, C; Laurini, E; Posocco, P; Pricl, S; Qu, FQ; Rocchi, P; Peng, L,期刊：Molecular Pharmaceutics, 页码：470-481 , 文章类型： Article，,卷期：2012年9-3]
- Successful achievement of RNA interference in therapeutic applications requires safe and efficient vectors for siRNA delivery. In the present study, we demonstrate that a triethanolamine (TEA)-core PAMAM dendrimer of gen...
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