- Multicomponent Synthetic Polymers with Viral-Mimetic Chemistry for Nucleic Acid Delivery
[作者：Soliman, M; Nasanit, R; Abulateefeh, SR; Allen, S; Davies, MC; Briggs, SS; Seymour, LW; Preece, JA; Grabowska, AM; Watson, SA; Alexander, C,期刊：Molecular Pharmaceutics, 页码：1-13 , 文章类型： Article，,卷期：2012年9-1]
- The ability to deliver genetic material for therapy remains an unsolved challenge in medicine. Natural gene carriers, such as viruses, have evolved sophisticated mechanisms and modular biopolymer architectures to overcom...
- Carbosilane Dendrimer 2G-NN16 Represses Tc17 Differentiation in Primary T CD8+ Lymphocytes
[作者：Gras, R; Garcia, MI; Gomez, R; de la Mata, FJ; Munoz-Fernandez, MA; Lopez-Fernandez, LA,期刊：Molecular Pharmaceutics, 页码：102-110 , 文章类型： Article，,卷期：2012年9-1]
- We studied changes in gene expression induced by the carbosilane dendrimer 2G-NN16 to evaluate their potential as a vehicle for gene therapy and as medication. Global gene expression profiles on CD8+ T lymphocytes reveal...
- Nanopolymeric Micelle Effect on the Transdermal Permeability, the Bioavailability and Gene Expression of Plasmid
[作者：Tong, YC; Yu, TY; Chang, SF; Liaw, J,期刊：Molecular Pharmaceutics, 页码：111-120 , 文章类型： Article，,卷期：2012年9-1]
- This study attempts to investigate the transdermal permeability, the bioavailability and gene expression of plasmid formulated with nonionic poly(ethylene oxide)poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) po...
- Unraveling the Intracellular Efficacy of Dextran-Histidine Polycation as an Efficient Nonviral Gene Delivery System
[作者：Thomas, JJ; Rekha, MR; Sharma, CP,期刊：Molecular Pharmaceutics, 页码：121-134 , 文章类型： Article，,卷期：2012年9-1]
- In this study, we attempted to elucidate the capability of a natural polymer dextran, by modification with histidine, to be an efficient, safe and promising nucleic acid delivery system in gene therapy. Physicochemical c...
- Filamentous, Mixed Micelles of Triblock Copolymers Enhance Tumor Localization of Indocyanine Green in a Murine Xenograft Model
[作者：Kim, TH; Mount, CW; Dulken, BW; Ramos, J; Fu, CJ; Khant, HA; Chiu, W; Gombotz, WR; Pun, SH,期刊：Molecular Pharmaceutics, 页码：135-143 , 文章类型： Article，,卷期：2012年9-1]
- Polymeric micelles formed by the self-assembly of amphiphilic block copolymers can be used to encapsulate hydrophobic drugs for tumor-delivery applications. Filamentous carriers with high aspect ratios offer potential ad...
- Enhanced Oral Absorption of Hydrophobic and Hydrophilic Drugs Using Quaternary Ammonium Palmitoyl Glycol Chitosan Nanoparticles
[作者：Siew, A; Le, H; Thiovolet, M; Gellert, P; Schatzlein, A; Uchegbu, I,期刊：Molecular Pharmaceutics, 页码：14-28 , 文章类型： Article，,卷期：2012年9-1]
- As 95% of all prescriptions are for orally administered drugs, the issue of oral absorption is central to the development of pharmaceuticals. Oral absorption is limited by a high molecular weight (>500 Da), a high log P ...
- Noninvasive Detection of Passively Targeted Poly(ethylene glycol) Nanocarriers in Tumors
[作者：Singh, Y; Gao, DY; Gu, ZC; Li, SK; Stein, S; Sinko, PJ,期刊：Molecular Pharmaceutics, 页码：144-155 , 文章类型： Article，,卷期：2012年9-1]
- The present studies noninvasively investigate the passive tumor distribution potential of a series of poly(ethylene glycol) (PEG) nanocarriers using a SkinSkan spectrofluorometer and an In Vivo Imaging System (IVIS) 100....
- A Single Sublingual Dose of an Adenovirus-Based Vaccine Protects against Lethal Ebola Challenge in Mice and Guinea Pigs
[作者：Choi, JH; Schafer, SC; Zhang, LH; Kobinger, GP; Juelich, T; Freiberg, AN; Croyle, MA,期刊：Molecular Pharmaceutics, 页码：156-167 , 文章类型： Article，,卷期：2012年9-1]
- Sublingual (SL) delivery, a noninvasive immunization method that bypasses the intestinal tract for direct entry into the circulation, was evaluated with an adenovirus (Ad5)-based vaccine for Ebola. Mice and guinea pigs w...
- Targeting Cell Surface Alpha(v)beta(3) Integrin Increases Therapeutic Efficacies of a Legumain Protease-Activated Auristatin Prodrug
[作者：Liu, Y; Bajjuri, KM; Liu, C; Sinha, SC,期刊：Molecular Pharmaceutics, 页码：168-175 , 文章类型： Article，,卷期：2012年9-1]
- Novel monomethylauristatin E (MMAE) prodrug 8 was designed and prepared that bound cell surface glycoprotein integrin alpha v beta 3, and was activated using legumain protease as a catalyst. Upon activation, prodrug 8 st...
- Estrogen-Anchored pH-Sensitive Liposomes as Nanomodule Designed for Site-Specific Delivery of Doxorubicin in Breast Cancer Therapy
[作者：Paliwal, SR; Paliwal, R; Pal, HC; Saxena, AK; Sharma, PR; Gupta, PN; Agrawal, GP; Vyas, SP,期刊：Molecular Pharmaceutics, 页码：176-186 , 文章类型： Article，,卷期：2012年9-1]
- The present investigation reports the development of nanoengineered estrogen receptor (ER) targeted pH-sensitive liposome for the site-specific intracellular delivery of doxorubicin (DOX) for breast cancer therapy. Estro...
- Improved Coiled-Coil Design Enhances Interaction with Bcr-Abl and Induces Apoptosis
[作者：Dixon, AS; Miller, GD; Bruno, BJ; Constance, JE; Woessner, DW; Fidle, TP; Robertson, JC; Cheatham, TE; Lim, CS,期刊：Molecular Pharmaceutics, 页码：187-195 , 文章类型： Article，,卷期：2012年9-1]
- The oncoprotein Bcr-Abl drives aberrant downstream activity through trans-autophosphorylation of homo-oligomers in chronic myelogenous leukemia (CML).(1,2) The formation of Bcr-Abl oligomers is achieved through the coile...
- Mechanistic Studies of the Effect of Bile Salts on Rhodamine 123 Uptake into RBE4 Cells
[作者：Yang, L; Fawcett, JP; Ostergaard, J; Zhang, H; Tucker, IG,期刊：Molecular Pharmaceutics, 页码：29-36 , 文章类型： Article，,卷期：2012年9-1]
- To examine the ability of bile salts (BS) to act as permeation enhancers at the blood brain barrier, the effect of four BS (cholate, deoxycholate, monoketocholate and taurocholate) on accumulation of rhodamine 123 (R123)...
- Effects of Solution Concentration on the Physicochemical Properties of a Polymeric Anticancer Therapeutic
[作者：Peng, LLX; Yu, L; Howell, SB; Gough, DA,期刊：Molecular Pharmaceutics, 页码：37-47 , 文章类型： Article，,卷期：2012年9-1]
- Poly(gamma-glutamyl-glutamate) paclitaxel (PGG-PTX) is a series of eighteen semiflexible polymer-drug constructs varying in PTX loading fraction (f(PTX) of 0.18, 0.24, and 0.37) and spatial PTX arrangement (uniform, "eve...
- Electrospun Fibers with Plasmid bFGF Polyplex Loadings Promote Skin Wound Healing in Diabetic Rats
[作者：Yang, Y; Xia, T; Chen, F; Wei, W; Liu, CY; He, SH; Li, XH,期刊：Molecular Pharmaceutics, 页码：48-58 , 文章类型： Article，,卷期：2012年9-1]
- Deep or chronic skin wounds are difficult to heal spontaneously due to the lack of scaffold to guide cell growth and reduced levels and activities of endogenous growth factors. Emulsion electrospinning process integrated...
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