- Dopamine- and tyramine-based derivatives of triazenes: Activation by tyrosinase and implications for prodrug design
[作者:Perry, MJ; Mendes, E; Simplicio, AL; Coelho, A; Soares, RV; Iley, J; Moreira, R; Francisco, AP,期刊:European Journal of Medicinal Chemistry, 页码:3228-3234 , 文章类型: Article,,卷期:2009年44-8]
- A range of triazene derivatives were synthesized and investigated as prodrug candidates for melanocyte-directed enzyme prodrug therapy (MDEPT). The prodrugs contained a tyramine or dopamine promoiety required for tyrosin...
- Photochemical electrocyclisation of 3-vinylindoles to pyrido[2,3-a]-, pyrido[4,3-a]- and thieno[2,3-a]-carbazoles: Design, synthesis, DNA binding and antitumor cell cytotoxicity
[作者:Lemster, T; Pinclur, U; Lenglet, G; Depauw, S; Dassi, C; David-Cordonnier, MH,期刊:European Journal of Medicinal Chemistry, 页码:3235-3252 , 文章类型: Article,,卷期:2009年44-8]
In the context of the design and synthesis of DNA ligands, some new hetarene annelated carbazoles were synthesized. As lead structure the intercalating tetracyclic systems pyrido[2,3-a]- and pyrido[4,3-a]-carbazoles a...
- Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N-3,N-5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides
[作者:Fassihi, A; Andpour, Z; Delbari, N; Saghaie, L; Memarian, HR; Sabet, R; Alborzi, A; Miri, R; Pourabbas, B; Mardaneh, J; Mousavi, P; Moeinifard, B; Sadeghi-Aliabadi, H,期刊:European Journal of Medicinal Chemistry, 页码:3253-3258 , 文章类型: Article,,卷期:2009年44-8]
- A series of 4-substituted imidazolyl-2,6-dimethyl-N-3,N-5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides were prepared. They were screened as antitubercular agents against Mycobacterium tuberculosis H(37)Rv. Minimum inhi...
- Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities
[作者:Suksrichavalit, T; PrachayasittikUl, S; Nantasenamat, C; Isarankura-Na-Ayudhya, C; Prachayasittikul, V,期刊:European Journal of Medicinal Chemistry, 页码:3259-3265 , 文章类型: Article,,卷期:2009年44-8]
- Superoxide anions are reactive oxygen species that can attack biomolecules such as DNA, lipids and proteins to cause many serious diseases. This study reports the synthesis of copper complexes of nicotinic acid with rela...
- Synthesis and in vivo antidiabetic activity of novel dispiropyrrolidines through [3+2] cycloaddition reactions with thiazolidinedione and rhodanine derivatives
[作者:Murugan, R; Anbazhagan, S; Narayanan, SS,期刊:European Journal of Medicinal Chemistry, 页码:3272-3279 , 文章类型: Article,,卷期:2009年44-8]
The synthesis of a series of novel dispiropyrrolidines has been accomplished by 1,3-dipolar cycloaddition reaction with 5-arylidene-1,3-thiazolidine-2,4-dione and 5-arylidene-4-thioxo-1,3-thiazolidine-2-one derivative...
- Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines
[作者:Rashad, AE; Hegab, MI; Abdel-Megeid, RE; Fathalla, N; Abdel-Megeid, FME,期刊:European Journal of Medicinal Chemistry, 页码:3285-3292 , 文章类型: Article,,卷期:2009年44-8]
5-Amino-1-substituted-1H-pyrazole-4-carbonitrile derivative 1 was used as a precursor for preparation of some novel substituted pyrazole and pyrazolo[3,4-d]pyrimidine derivatives 2-10. Furthermore, the preparation of ...
- Berbamine derivatives: A novel class of compounds for anti-leukemia activity
[作者:Xie, JW; Ma, T; Gu, Y; Zhang, XZ; Qiu, X; Zhang, L; Xu, RZ; Yu, YP,期刊:European Journal of Medicinal Chemistry, 页码:3293-3298 , 文章类型: Article,,卷期:2009年44-8]
- Our previous studies showed that the natural compound berbamine, from Chinese herb Berberis amurensis, selectively induces apoptosis of imatinib (IM)-resistant-Bcr/Abl-expressing leukemia cells from the K562 cell line an...
- Antimicrobial active macrocyclic complexes of Cr(III), Mn(III) and Fe(III) with their spectroscopic approach
[作者:Singh, DP; Kumar, K; Sharma, C,期刊:European Journal of Medicinal Chemistry, 页码:3299-3304 , 文章类型: Article,,卷期:2009年44-8]
- A novel series of macrocyclic complexes of the type [M(C48H32N4)X]X-2; where M = Cr(III), Fe(III) and Mn(III); X = Cl-, NO3-, CH3COO- have been synthesized by template condensation of 1,8-diaminonaphthalene and benzil in...
- Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
[作者:Lyakhova, EA; Gusyeva, YA; Nekhoroshkova, JV; Shafran, LM; Lyakhov, SA,期刊:European Journal of Medicinal Chemistry, 页码:3305-3312 , 文章类型: Article,,卷期:2009年44-8]
- Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzojmidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by t...
- Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1 ',2 '-bis(hydroxymethyl)cycloprop-1 '-yl]methyl}guanine analogues
[作者:Ostrowski, T; Golankiewicz, B; De Clercq, E; Andrei, G; Snoeck, R,期刊:European Journal of Medicinal Chemistry, 页码:3313-3317 , 文章类型: Article,,卷期:2009年44-8]
- A series of tricyclic analogues of acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine substituted in the 6 position with thien-2-yl, 5-bromothien-2-yl or furan-2-yl group were synthesized. The n...
- Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors
[作者:Wang, LT; Zhang, B; Ji, JX; Li, BG; Yan, JF; Zhang, WY; Wu, Y; Wang, XC,期刊:European Journal of Medicinal Chemistry, 页码:3318-3322 , 文章类型: Article,,卷期:2009年44-8]
- To find potent and selective inhibitors of dipeptidyl peptidase IV (DPP-IV), we synthesized a series of 2-cyanopyrrolidine derivatives with constrained imidazolidin ring and tested their activities against DPP-IV. Most o...
- Copper(II) and uranyl(II) complexes with acylthiosemicarbazide: Synthesis, characterization, antibacterial activity and effects on the growth of promyelocytic leukemia cells HL-60
[作者:Angelusiu, MV; Almajan, GL; Rosu, T; Negoiu, M; Almajan, ER; Roy, J,期刊:European Journal of Medicinal Chemistry, 页码:3323-3329 , 文章类型: Article,,卷期:2009年44-8]
- New chelates of N-1-14-(4-X-phenyisulfonyl)benzoyl]-N-4-butyl-thiosemicarbazide (X = H, Cl, BF) with Cu2+ and UO22+ have been prepared and characterized by analytical and physico-chemical techniques such as magnetic susc...
- Mono and bis-6-arylbenzimidazo[1,2-c]quinazolines: A new class of antimicrobial agents
[作者:Rohini, R; Shanker, K; Reddy, PM; Ho, YP; Ravinder, V,期刊:European Journal of Medicinal Chemistry, 页码:3330-3339 , 文章类型: Article,,卷期:2009年44-8]
- With the aim of obtaining novel biologically active compounds, we have synthesized a series of mono, bis-2-o-arylideneaminophenylbenzimidazoles and a second series of corresponding mono, bis-6-arylbenzimiclazo[ 1,2-c]qui...
- Synthesis of new chiral 2,5-disubstituted 1,3,4-thiadiazoles possessing gamma-butenolide moiety and preliminary evaluation of in vitro anticancer activity
[作者:Wei, MX; Feng, L; Li, XQ; Zhou, XZ; Shao, ZH,期刊:European Journal of Medicinal Chemistry, 页码:3340-3344 , 文章类型: Article,,卷期:2009年44-8]
A new series of chiral 1,3,4-thiadiazoles derivatives possessing gamma-substituted butenolide moiety were synthesized and evaluated for in vitro anticancer properties. All the compounds showed good anticancer activiti...
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