- Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
[作者:Padmavathi, V; Reddy, GS; Padmaja, A; Kondaiah, P; Ali-Shazia,期刊:European Journal of Medicinal Chemistry, 页码:2106-2112 , 文章类型: Article,,卷期:2009年44-5]
- A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to thiadiazoles and triazoles was...
- Novel 4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains: Design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell
[作者:Ke, SY; Qian, XH; Liu, FY; Wang, N; Yang, Q; Li, Z,期刊:European Journal of Medicinal Chemistry, 页码:2113-2121 , 文章类型: Article,,卷期:2009年44-5]
- A new series of nitrogen-containing heterocycles 4H-1,3,4-oxadiazin-5(6H)-ones derivatives with hydrophobic and long chains were designed and synthesized by direct cyclization reaction of N-alkylation substituted aroylhy...
- Design, cytotoxic and fluorescent properties of novel N-phosphorylalkyl substituted E,E-3,5-bis(arylidene)piperid-4-ones
[作者:Makarov, MV; Rybalkina, EY; Roschenthaler, GV; Short, KW; Tirnofeeva, TV; Odinets, IL,期刊:European Journal of Medicinal Chemistry, 页码:2135-2144 , 文章类型: Article,,卷期:2009年44-5]
- A series of EE-N-phosphorylalkylene-3,5-bis(arylidene)piperid-4-ones 7a-k was prepared via the condensation of aromatic aldehydes with omega-aminophosphonates 5a-c and 6a,b bearing piperidone or a protected piperidone mo...
- Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives
[作者:Fassihi, A; Abedi, D; Saghaie, L; Sabet, R; Fazeli, H; Bostaki, G; Deilami, O; Sadinpour, H,期刊:European Journal of Medicinal Chemistry, 页码:2145-2157 , 文章类型: Article,,卷期:2009年44-5]
- A series of Mannich bases of 2-alkyl-3-hydroxy-pyridine-4-ones, namely 2-alkyl-3-hydroxy-5-N-piperidylmethyl or N,N-dialkylaminomethyl pyridine-4-ones 9, 10 and 15-18, two derivatives of N-aryl-2methyl-3-hydroxy-pyridine...
- Facile synthesis of bis(4,5-dihydro-1H-pyrazole-1-carboxamides) and their thio-analogues of potential PGE(2) inhibitory properties
[作者:Barsoum, FF; Girgis, AS,期刊:European Journal of Medicinal Chemistry, 页码:2172-2177 , 文章类型: Article,,卷期:2009年44-5]
- A variety of bis(3-aryl-4,5-dihydro-1H-pyrazole-1-thiocarboxamides) 2a-h were prepared via reaction of bis(2-propen-1-ones) 1a-h with thiosemicarbazide in ethanolic KOH solution. Meanwhile, bis(3-aryl-4,5-dihydro-1H-pyra...
- Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-kappa B and AP-1 mediated transcription activation and as potential anti-inflammatory agents
[作者:Giri, RS; Thaker, HM; Giordano, T; Williams, J; Rogers, D; Sudersanam, V; Vasu, KK,期刊:European Journal of Medicinal Chemistry, 页码:2184-2189 , 文章类型: Article,,卷期:2009年44-5]
- A series of 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives were designed and synthesized. Synthesized molecules were further evaluated for their inhibitory activity towards transcription fact...
- Antifungal unsaturated cyclic Mannich ketones and amino alcohols: Study of mechanism of action
[作者:Kocsis, B; Kustos, I; Ferenc, K; Nyul, A; Jakus, PB; Szilard, K; Villarreal, V; Laszlo, P; Lorand, T,期刊:European Journal of Medicinal Chemistry, 页码:1823-1829 , 文章类型: Article,,卷期:2009年44-5]
- The antifungal activity of some known unsaturated Mannich ketones and their amino alcohols has been reported and the mechanism of antifungal action has been studied. The inhibition of the fungal ergosterol, chitin, prote...
- Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors
[作者:Dundar, Y; Unlu, S; Banoglu, E; Entrena, A; Costantino, G; Nunez, MT; Ledo, F; Sahin, MF; Noyanalpan, N,期刊:European Journal of Medicinal Chemistry, 页码:1830-1837 , 文章类型: Article,,卷期:2009年44-5]
- A series of 3-unsubstituted/substituted-4,5-diphenyl-2-oxo-3H-1,3-oxazole derivatives were prepared as selective cyclooxygenase-2 (COX-2) inhibitors. Among the synthesized compounds, 4-(4-phenyl-3-methyl-2-oxo-3H-1,3-oxa...
- Parallel synthesis, molecular modelling and further structure-activity relationship studies of new acylthiocarbamates as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
[作者:Spallarossa, A; Cesarini, S; Ranise, A; Schenone, S; Bruno, O; Borassi, A; La Colla, P; Pezzullo, M; Sanna, G; Collu, G; Secci, B; Loddo, R,期刊:European Journal of Medicinal Chemistry, 页码:2190-2201 , 文章类型: Article,,卷期:2009年44-5]
- The structure-activity relationships (SARs) of acylthiocarbamates (ATCs), a new class of non-nucleoside HIV-1 reverse transcriptase inhibitors, have been expanded. Sixty-six new analogues were prepared by parallel soluti...
- Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles
[作者:Zhang, DT; Wang, ZH; Xu, WR; Sun, FG; Tang, LD; Wang, JW,期刊:European Journal of Medicinal Chemistry, 页码:2202-2210 , 文章类型: Article,,卷期:2009年44-5]
- A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of all the synthesized compounds were confirmed by analytical and...
- Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted
[作者:Batovska, D; Parushev, S; Stambohyska, B; Tsvetkova, I; Ninova, M; Najdenski, H,期刊:European Journal of Medicinal Chemistry, 页码:2211-2218 , 文章类型: Article,,卷期:2009年44-5]
- A large series of chalcones were synthesized and studied against Staphylococcus aureus and Escherichia coli. Chalcones were either unsubstituted in ring A or possessed 4-chloro or 3',4',5'-trimethoxy groups. Their other ...
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