- Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids
[作者:Senthilkumar, P; Dinakaran, M; Yogeeswari, P; Sriram, D; China, A; Nagaraja, V,期刊:European Journal of Medicinal Chemistry, 页码:345-358 , 文章类型: Article,,卷期:2009年44-1]
Various 1-(substituted)-1,4-dihydro-6-nitro-4-oxo-7-(sub-secondary amino)-quinoline-3-carboxylic acids were synthesized from 2,4-dichlorobenzoic acid by six step synthesis. The compounds were evaluated for antimycobac...
- QSAR modelling of pancreatic beta-cell K-ATP channel openers R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(substituted phenylaminocarbonylamino)-2H-1-benzopyrans using MLR-FA techniques
[作者:Alam, SM; Samanta, S; Halder, AK; Basu, S; Jha, T,期刊:European Journal of Medicinal Chemistry, 页码:359-364 , 文章类型: Article,,卷期:2009年44-1]
Potassium (K+) channel openers are a diverse group of compounds which are used for the treatment of diseases like angina pectoris, hypertension, congestive heart failure, anti-hypoglycemic (insulinoma), bronchial asth...
- Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds
[作者:Aghatabay, NM; Mahmiani, Y; Cevik, H; Dulger, B,期刊:European Journal of Medicinal Chemistry, 页码:365-372 , 文章类型: Article,,卷期:2009年44-1]
Mixed aza-oxo-thia macrocyclic ligands 1,3,5,11,13,15-hexaaza-6,10,16,20-tetraoxo-8,18-dithia-2,3,4:12,13,14-dipyridine cyclocosane (L-1); 1,3,5,12,14,16-hexeaza-6,11,17,22-tetraoxo-8,9,19,20-tetrathia-2,3,4:13,14,15-...
- Synthesis, HIV-RT inhibitory activity and SAR of 1-benzyl-1H-1,2,3-triazole derivatives of carbohydrates
[作者:da Silva, FD; Souza, MCBV; Frugulhetti, IIP; Castro, HC; Souza, SLDO; de Souza, TML; Rodrigues, DQ; Souza, AMT; Abreu, PA; Passamani, F; Rodrigues, CR; Ferreira, VF,期刊:European Journal of Medicinal Chemistry, 页码:373-383 , 文章类型: Article,,卷期:2009年44-1]
This paper describes the synthesis of several 1-benzyl-1H-1,2,3-triazoles attached to different carbohydrate templates and their in vitro inhibitory profile against HIV-1 reverse transcriptase. In addition a theoretic...
- Synthesis and use of 4-peptidylhydrazido-N-hexyl-1,8-naphthalimides as fluorogenic histochemical substrates for dipeptidyl peptidase IV and tripeptidyl peptidase I
[作者:Ivanov, I; Tasheva, D; Todorova, R; Dimitrova, M,期刊:European Journal of Medicinal Chemistry, 页码:384-392 , 文章类型: Article,,卷期:2009年44-1]
Gly-Pro-, Gly-Pro-Met- and Ala-Ala-Phe-N'-(2-hexyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)-hydrazides are synthesized by guanidinium/uronium type condensing reagent and used as fluorogenic substrates to lo...
- Synthesis, cytotoxicity and apoptosis of naphthalimide polyamine conjugates as antitumor agents
[作者:Tian, ZY; Xie, SQ; Du, YW; Ma, YF; Zhao, J; Gao, WY; Wang, CJ,期刊:European Journal of Medicinal Chemistry, 页码:393-399 , 文章类型: Article,,卷期:2009年44-1]
Several naphthalimide polyamine conjugates were synthesized and evaluated for in vitro cytotoxicity against human leukemia K562, murine melanoma B16, Chinese hamster ovary CHO cell lines. Both triamine moieties and th...
- Synthesis and biological evaluation of novel symmetry bis-enediynes
[作者:Tseng, KF; Lin, CF; Lo, YH; Hu, YL; Chen, LY; Yang, SH; Lin, SR; Chang, LS; Wu, MJ,期刊:European Journal of Medicinal Chemistry, 页码:35-41 , 文章类型: Article,,卷期:2009年44-1]
A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibit...
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