- Essential Roles of an Intercalated Disc Protein, mXin beta, in Postnatal Heart Growth and Survival
[作者：Wang, QC; Lin, JLC; Reinking, BE; Feng, HZ; Chan, FC; Lin, CI; Jin, JP; Gustafson-Wagner, EA; Scholz, TD; Yang, BL; Lin, JJC,期刊：Circulation Research, 页码：1468-1468 , 文章类型： Article，,卷期：2010年106-9]
- Rationale: The Xin repeat-containing proteins mXin alpha and mXin beta localize to the intercalated disc of mouse heart and are implicated in cardiac development and function. The mXin alpha directly interacts with beta-...
- Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein-Induced Macrophage Death
[作者：Lee, CF; Qiao, M; Schroder, K; Zhao, QW; Asmis, R,期刊：Circulation Research, 页码：1489-1489 , 文章类型： Article，,卷期：2010年106-9]
- Rationale: The enhanced formation of intracellular reactive oxygen species (ROS) induced by oxidized low-density lipoprotein (OxLDL) promotes macrophage death, a process likely to contribute to the formation of necrotic ...
- Regulation of Cardiomyocyte Polyploidy and Multinucleation by CyclinG1
[作者：Liu, ZP; Yue, SJ; Chen, XB; Kubin, T; Braun, T,期刊：Circulation Research, 页码：1498-1498 , 文章类型： Article，,卷期：2010年106-9]
- Rationale: Polyploidy and multinucleation are characteristic features of mammalian cardiomyocytes, which develop shortly after birth when most differentiated cardiomyocytes become acytokinetic. Cardiac overload and hyper...
- Pregnenolone Sulphate- and Cholesterol-Regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction
[作者：Naylor, J; Li, J; Milligan, CJ; Zeng, FN; Sukumar, P; Hou, B; Sedo, A; Yuldasheva, N; Majeed, Y; Beri, D; Jiang, S; Seymour, VAL; McKeown, L; Kumar, B; Harteneck, C; O'Regan, D; Wheatcroft, SB; Kearney, MT; Jones, C; Porter, KE; Beech, DJ,期刊：Circulation Research, 页码：1507-1507 , 文章类型： Article，,卷期：2010年106-9]
- Rationale: Transient receptor potential melastatin (TRPM) 3 is a calcium-permeable ion channel activated by the neurosteroid pregnenolone sulfate and positively coupled to insulin secretion in beta cells. Although vascul...
- TRB3 Function in Cardiac Endoplasmic Reticulum Stress
[作者：Avery, J; Etzion, S; DeBosch, BJ; Jin, XH; Lupu, TS; Beitinjaneh, B; Grand, J; Kovacs, A; Sambandam, N; Muslin, AJ,期刊：Circulation Research, 页码：1516-1516 , 文章类型： Article，,卷期：2010年106-9]
- Rationale: Tribbles (TRB)3 is an intracellular pseudokinase that modulates the activity of several signal transduction cascades. TRB3 has been reported to inhibit the activity of Akt protein kinases. TRB3 gene expression...
- Effects of Free Immunoglobulin Light Chains on Viral Myocarditis
[作者：Matsumori, A; Shimada, M; Jie, X; Higuchi, H; Kormelink, TG; Redegeld, FA,期刊：Circulation Research, 页码：1533-1540 , 文章类型： Article，,卷期：2010年106-9]
- Rationale: In recent work, we have demonstrated a crucial role of mast cells in the development of viral myocarditis. Viral infection could lead to increased synthesis of free immunoglobulin light chains (FLC) and our ea...
- Defective DNA Replication Impairs Mitochondrial Biogenesis In Human Failing Hearts
[作者：Karamanlidis, G; Nascimben, L; Couper, GS; Shekar, PS; del Monte, F; Tian, R,期刊：Circulation Research, 页码：1541-1541 , 文章类型： Article，,卷期：2010年106-9]
- Rationale: Mitochondrial dysfunction plays a pivotal role in the development of heart failure. Animal studies suggest that impaired mitochondrial biogenesis attributable to downregulation of the peroxisome proliferator-a...
- The Cardiac Myosin Binding Protein C Arg502Trp Mutation A Common Cause of Hypertrophic Cardiomyopathy
[作者：Saltzman, AJ; Mancini-DiNardo, D; Li, CM; Chung, WK; Ho, CY; Hurst, S; Wynn, J; Care, M; Hamilton, RM; Seidman, GW; Gorham, J; McDonough, B; Sparks, E; Seidman, JG; Seidman, CE; Rehm, HL,期刊：Circulation Research, 页码：1549-1549 , 文章类型： Article，,卷期：2010年106-9]
- Rationale: The myosin-binding protein C isoform 3 (MYBPC3) variant Arg502Trp has been identified in multiple hypertrophic cardiomyopathy (HCM) cases, but compelling evidence to support or refute the pathogenicity of this...
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