- Potential Therapeutic Targets for Cardiac Fibrosis TGF beta, Angiotensin, Endothelin, CCN2, and PDGF, Partners in Fibroblast Activation
[作者：Leask, A,期刊：Circulation Research, 页码：1675-1680 , 文章类型： Review，,卷期：2010年106-11]
- Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because of a persistent tissue repair program. During connective tissue repair, "activated" fibroblasts migrate int...
- Sex Differences in the Phosphorylation of Mitochondrial Proteins Result in Reduced Production of Reactive Oxygen Species and Cardioprotection in Females
[作者：Lagranha, CJ; Deschamps, A; Aponte, A; Steenbergen, C; Murphy, E,期刊：Circulation Research, 页码：1681-1681 , 文章类型： Article，,卷期：2010年106-11]
- Rationale: Although premenopausal females have a lower risk for cardiovascular disease, the mechanism(s) are poorly understood. Objective: We tested the hypothesis that cardioprotection in females is mediated by altered ...
- Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury
[作者：Naito, AT; Okada, S; Minamino, T; Iwanaga, K; Liu, ML; Sumida, T; Nomura, S; Sahara, N; Mizoroki, T; Takashima, A; Akazawa, H; Nagai, T; Shiojima, I; Komuro, I,期刊：Circulation Research, 页码：1692-1692 , 文章类型： Article，,卷期：2010年106-11]
- Rationale: The number of patients with coronary heart disease, including myocardial infarction, is increasing and novel therapeutic strategy is awaited. Tumor suppressor protein p53 accumulates in the myocardium after my...
- Atheroprone Hemodynamics Regulate Fibronectin Deposition to Create Positive Feedback That Sustains Endothelial Inflammation
[作者：Feaver, RE; Gelfand, BD; Wang, C; Schwartz, MA; Blackman, BR,期刊：Circulation Research, 页码：1703-1703 , 文章类型： Article，,卷期：2010年106-11]
- Rationale: The extracellular matrix protein fibronectin (FN) is focally deposited in regions of atherosclerosis, where it contributes to inflammatory signaling. Objective: To elucidate the mechanism by which FN depositio...
- Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by Peroxisome Proliferator-Activated Receptor beta/delta and Protects Against Fatty Acid-Induced Oxidative Stress
[作者：Georgiadi, A; Lichtenstein, L; Degenhardt, T; Boekschoten, MV; van Bilsen, M; Desvergne, B; Muller, M; Kersten, S,期刊：Circulation Research, 页码：1712-1721 , 文章类型： Article，,卷期：2010年106-11]
- Rationale: Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact heart. Objective: To study the effect of dietary fa...
- Erythropoietin Activates Mitochondrial Biogenesis and Couples Red Cell Mass to Mitochondrial Mass in the Heart
[作者：Carraway, MS; Suliman, HB; Jones, WS; Chen, CW; Babiker, A; Piantadosi, CA,期刊：Circulation Research, 页码：1722-1722 , 文章类型： Article，,卷期：2010年106-11]
- Rationale: Erythropoietin (EPO) is often administered to cardiac patients with anemia, particularly from chronic kidney disease, and stimulation of erythropoiesis may stabilize left ventricular and renal function by recr...
- Role of Afadin in Vascular Endothelial Growth Factor- and Sphingosine 1-Phosphate-Induced Angiogenesis
[作者：Tawa, H; Rikitake, Y; Takahashi, M; Amano, H; Miyata, M; Satomi-Kobayashi, S; Kinugasa, M; Nagamatsu, Y; Majima, T; Ogita, H; Miyoshi, J; Hirata, K; Takai, Y,期刊：Circulation Research, 页码：1731-1731 , 文章类型： Article，,卷期：2010年106-11]
- Rationale: Angiogenesis contributes to physiological and pathological conditions, including atherosclerosis. The Rap1 small G protein regulates vascular integrity and angiogenesis. However, little is known about the effe...
- Kinetics of FKBP12.6 Binding to Ryanodine Receptors in Permeabilized Cardiac Myocytes and Effects on Ca Sparks
[作者：Guo, T; Cornea, RL; Huke, S; Camors, E; Yang, Y; Picht, E; Fruen, BR; Bers, DM,期刊：Circulation Research, 页码：1743-1743 , 文章类型： Article，,卷期：2010年106-11]
- Rationale: FK506-binding proteins FKBP12.6 and FKBP12 are associated with cardiac ryanodine receptors (RyR2), and cAMP-dependent protein kinase A (PKA)-dependent phosphorylation of RyR2 was proposed to interrupt FKBP12.6...
- Genetic Modification of Mesenchymal Stem Cells Overexpressing CCR1 Increases Cell Viability, Migration, Engraftment, and Capillary Density in the Injured Myocardium
[作者：Huang, J; Zhang, ZP; Guo, JA; Ni, AG; Deb, A; Zhang, LN; Mirotsou, M; Pratt, RE; Dzau, VJ,期刊：Circulation Research, 页码：1753-1753 , 文章类型： Article，,卷期：2010年106-11]
- Rationale: Although mesenchymal stem cell (MSC) transplantation has been shown to promote cardiac repair in acute myocardial injury in vivo, its overall restorative capacity appears to be restricted mainly because of poo...
- Silencing Nox4 in the Paraventricular Nucleus Improves Myocardial Infarction-Induced Cardiac Dysfunction by Attenuating Sympathoexcitation and Periinfarct Apoptosis
[作者：Infanger, DW; Cao, XA; Butler, SD; Burmeister, MA; Zhou, Y; Stupinski, JA; Sharma, RV; Davisson, RL,期刊：Circulation Research, 页码：1763-1763 , 文章类型： Article，,卷期：2010年106-11]
- Rationale: Myocardial infarction (MI)-induced heart failure is characterized by central nervous system-driven sympathoexcitation and deteriorating cardiac function. The paraventricular nucleus (PVN) of the hypothalamus i...
- Increased Cell and Matrix Accumulation During Atherogenesis in Mice With Vessel Wall-Specific Deletion of Discoidin Domain Receptor 1
[作者：Franco, C; Ahmad, PJ; Hou, GP; Wong, E; Bendeck, MP,期刊：Circulation Research, 页码：1775-1775 , 文章类型： Article，,卷期：2010年106-11]
- Rationale: Discoidin domain receptor (DDR)1 is a collagen receptor expressed on both smooth muscle cells (SMCs) and macrophages, where it plays important roles regulating cell and matrix accumulation during atherogenesis...
|