- Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes
[作者:Wossidlo, M; Arand, J; Sebastiano, V; Lepikhov, K; Boiani, M; Reinhardt, R; Scholer, H; Walter, J,期刊:EMBO journal, 页码:1877-1888 , 文章类型: Article,,卷期:2010年29-11]
- In mammalian zygotes, the 5-methyl-cytosine (5mC) content of paternal chromosomes is rapidly changed by a yet unknown but presumably active enzymatic mechanism. Here, we describe the developmental dynamics and parental a...
- Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics
[作者:Rust, MB; Gurniak, CB; Renner, M; Vara, H; Morando, L; Gorlich, A; Sassoe-Pognetto, M; Al Banchaabouchi, M; Giustetto, M; Triller, A; Choquet, D; Witke, W,期刊:EMBO journal, 页码:1889-1902 , 文章类型: Article,,卷期:2010年29-11]
- Neuronal plasticity is an important process for learning, memory and complex behaviour. Rapid remodelling of the actin cytoskeleton in the postsynaptic compartment is thought to have an important function for synaptic pl...
- PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock
[作者:Wang, L; Fujiwara, S; Somers, DE,期刊:EMBO journal, 页码:1903-1915 , 文章类型: Article,,卷期:2010年29-11]
- Many core oscillator components of the circadian clock are nuclear localized but how the phase and rate of their entry contribute to clock function is unknown. TOC1/PRR1, a pseudoresponse regulator (PRR) protein, is a ce...
- Rice early flowering1, a CKI, phosphorylates DELLA protein SLR1 to negatively regulate gibberellin signalling
[作者:Dai, C; Xue, HW,期刊:EMBO journal, 页码:1916-1927 , 文章类型: Article,,卷期:2010年29-11]
- The plant hormone gibberellin (GA) is crucial for multiple aspects of plant growth and development. To study the relevant regulatory mechanisms, we isolated a rice mutant earlier flowering1, el1, which is deficient in a ...
- Deciphering the assembly of the Yersinia type III secretion injectisome
[作者:Diepold, A; Amstutz, M; Abel, S; Sorg, I; Jenal, U; Cornelis, GR,期刊:EMBO journal, 页码:1928-1940 , 文章类型: Article,,卷期:2010年29-11]
- The assembly of the Yersinia enterocolitica type III secretion injectisome was investigated by grafting fluorescent proteins onto several components, YscC (outer-membrane (OM) ring), YscD (forms the inner-membrane (IM) r...
- AP-1/sigma 1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory (vol 29, pg 1318, 2010)
[作者:Glyvuk, N; Tsytsyura, Y; Geumann, C; D'Hooge, R; Huve, J; Kratzke, M; Baltes, J; Boening, D; Klingauf, J; Schu, P,期刊:EMBO journal, 页码:1941-1941 , 文章类型: Correction,,卷期:2010年29-11]
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- LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
[作者:Weidberg, H; Shvets, E; Shpilka, T; Shimron, F; Shinder, V; Elazar, Z,期刊:EMBO journal, 页码:1792-1802 , 文章类型: Article,,卷期:2010年29-11]
- Autophagy, a critical process for bulk degradation of proteins and organelles, requires conjugation of Atg8 proteins to phosphatidylethanolamine on the autophagic membrane. At least eight different Atg8 orthologs belongi...
- The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
[作者:Lin, YW; Wu, YD; Li, JL; Dong, CF; Ye, XF; Chi, YI; Evers, BM; Zhou, BP,期刊:EMBO journal, 页码:1803-1816 , 文章类型: Article,,卷期:2010年29-11]
- Epithelial-mesenchymal transition (EMT) is a transdifferentiation programme. The mechanism underlying the epigenetic regulation of EMT remains unclear. In this study, we identified that Snail1 interacted with histone lys...
- Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene
[作者:Campion, Y; Neel, H; Gostan, T; Soret, J; Bordonne, R,期刊:EMBO journal, 页码:1817-1829 , 文章类型: Article,,卷期:2010年29-11]
- Spinal muscular atrophy results from deletions or mutations in the survival of motor neuron (SMN1) gene. The SMN protein has an essential role in the biogenesis of spliceosomal snRNPs, but the link between a defect in th...
- Two antisense RNAs target the transcriptional regulator CsgD to inhibit curli synthesis
[作者:Holmqvist, E; Reimegard, J; Sterk, M; Grantcharova, N; Romling, U; Wagner, EGH,期刊:EMBO journal, 页码:1840-1850 , 文章类型: Article,,卷期:2010年29-11]
- Escherichia coli produces proteinaceous surface structures called curli that are involved in adhesion and biofilm formation. CsgD is the transcriptional activator of curli genes. We show here that csgD expression is, in ...
- Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAs
[作者:Boyne, JR; Jackson, BR; Taylor, A; Macnab, SA; Whitehouse, A,期刊:EMBO journal, 页码:1851-1864 , 文章类型: Article,,卷期:2010年29-11]
- Kaposi's sarcoma-associated herpesvirus (KSHV) expresses numerous intronless mRNAs that are unable to access splicing-dependent cellular mRNA nuclear export pathways. To circumvent this problem, KSHV encodes the open rea...
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