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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Experimental Methods for Studying the Interactions between G-Quadruplex Structures and Ligands [作者：Jaumot, J; Gargallo, R,期刊：Current Pharmaceutical Design, 页码：1900-1916 , 文章类型： Review，,卷期：2012年18-14] The present paper reviews the recent advances in and applications of experimental techniques used to study interactions between G-quadruplex structures and ligands that are potentially of pharmaceutical interest. Several... Recent Developments in the Chemistry and Biology of G-Quadruplexes with Reference to the DNA Groove Binders [作者：Jain, AK; Bhattacharya, S,期刊：Current Pharmaceutical Design, 页码：1917-1933 , 文章类型： Review，,卷期：2012年18-14] DNA is the chemotherapeutic target for treating diseases of genetic origin. Besides well-known double-helical structures (A, B, Z, parallel stranded-DNA etc.), DNA is capable of forming several multi-stranded structures ... Heterocyclic Dications as a New Class of Telomeric G-Quadruplex Targeting Agents [作者：Nanjunda, R; Musetti, C; Kumar, A; Ismail, MA; Farahat, AA; Wang, SM; Sissi, C; Palumbo, M; Boykin, DW; Wilson, WD,期刊：Current Pharmaceutical Design, 页码：1934-1947 , 文章类型： Review，,卷期：2012年18-14] Small molecules that can induce and stabilize G-quadruplex DNA structures represent a novel approach for anti-cancer and anti-parasitic therapy and extensive efforts have been directed towards discovering lead compounds ... G-Quadruplex Binding Ligands: from Naturally Occurring to Rationally Designed Molecules [作者：Le, TVT; Han, S; Chae, J; Park, HJ,期刊：Current Pharmaceutical Design, 页码：1948-1972 , 文章类型： Review，,卷期：2012年18-14] Guanine-rich nucleic acid sequences are known to form G-quadruplex -four-stranded DNA or RNA structures stabilized by an array of Hoogsteen hydrogen bonds. G-quadruplex structures are involved in the modulation of gene e... Searching Drug-Like Anti-cancer Compound(s) Based on G-Quadruplex Ligands [作者：Li, Q; Xiang, JF; Zhang, H; Tang, YL,期刊：Current Pharmaceutical Design, 页码：1973-1983 , 文章类型： Review，,卷期：2012年18-14] G-quadruplex structure is a four-stranded form of DNA, which is associated with cancer cell proliferation. G-quadruplex-stabilized ligands have the potential to interfere with telomere replication by blocking the elongat... Targeting DNA G-Quadruplex Structures with Peptide Nucleic Acids [作者：Panyutin, IG; Onyshchenko, MI; Englund, EA; Appella, DH; Neumann, RD,期刊：Current Pharmaceutical Design, 页码：1984-1991 , 文章类型： Review，,卷期：2012年18-14] Regulation of genetic functions based on targeting DNA or RNA sequences with complementary oligonucleotides is especially attractive in the post-genome era. Oligonucleotides can be rationally designed to bind their targe... Screening of a Chemical Library by HT-G4-FID for Discovery of Selective G-quadruplex Binders [作者：Largy, E; Saettel, N; Hamon, F; Dubruille, S; Teulade-Fichou, MP,期刊：Current Pharmaceutical Design, 页码：1992-2001 , 文章类型： Review，,卷期：2012年18-14] Due to the lack of structural guidelines about G-quadruplex ligands, rational design cannot be the only approach to discover potent G4-ligands. As a complementary approach, screening of chemical library may provide inter... Structure Conversion and Structure Separation of G-Quadruplexes Investigated by Carbazole Derivatives [作者：Chang, TC; Chu, JF; Tsai, YL; Wang, ZF,期刊：Current Pharmaceutical Design, 页码：2002-2013 , 文章类型： Review，,卷期：2012年18-14] The challenge of G-quadruplexes is that the G-rich sequences can adopt various G4 structures and possibly interconvert among them, particularly under the change of environmental conditions. Both NMR and circular dichrois... G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application [作者：Tucker, WO; Shum, KT; Tanner, JA,期刊：Current Pharmaceutical Design, 页码：2014-2026 , 文章类型： Review，,卷期：2012年18-14] Highly specific and tight-binding nucleic acid aptamers have been selected against a variety of molecular targets for over 20 years. A significant proportion of these oligonucleotides display G-quadruplex structures, par... Folding Versus Charge: Understanding Selective Target Recognition by the Thrombin Apta\mers [作者：Marson, G; Palumbo, M; Sissi, C,期刊：Current Pharmaceutical Design, 页码：2027-2035 , 文章类型： Review，,卷期：2012年18-14] The use of nucleic acids as drugs represents a consistently growing approach. Different therapeutical strategies take advantage of the biological and biophysical properties of DNA and RNA to properly modulate activity of... Thrombin Binding Aptamer, More than a Simple Aptamer: Chemically Modified Derivatives and Biomedical Applications [作者：Avino, A; Fabrega, C; Tintore, M; Eritja, R,期刊：Current Pharmaceutical Design, 页码：2036-2047 , 文章类型： Review，,卷期：2012年18-14] The thrombin binding aptamer (TBA) is a well characterized chair-like, antiparallel quadruplex structure that binds specifically to thrombin at nanomolar concentrations and therefore it has interesting anticoagulant prop... G-Quadruplex Based Probes for Visual Detection and Sensing [作者：Neo, JL; Kamaladasan, K; Uttamchandani, M,期刊：Current Pharmaceutical Design, 页码：2048-2057 , 文章类型： Review，,卷期：2012年18-14] Recent advances in colorimetric biosensing have led to rapid methods for target detection, potentially leading to applications on-site, at the point-of-need. This review focuses on one such platform, the G-quadruplex-hem... Luminescent G-quadruplex Probes [作者：Ma, DL; Chan, DSH; Yang, H; He, HZ; Leung, CH,期刊：Current Pharmaceutical Design, 页码：2058-2075 , 文章类型： Review，,卷期：2012年18-14] G-quadruplexes have found increasing potential in applications such as molecular therapeutics, diagnostics, and sensing. As a consequence, small molecules capable of selectively detecting G-quadruplexes have received sig... G-Quadruplex as Signal Transducer for Biorecognition Events [作者：Lv, L; Guo, ZJ; Wang, JH; Wang, EK,期刊：Current Pharmaceutical Design, 页码：2076-2095 , 文章类型： Review，,卷期：2012年18-14] G-rich nucleic acid oligomers can form G-quadruplexes built by G-tetrads stacked upon each other. The basic building block of the G-quadruplexes is similar, but the formation of different quadruplex structures is highly ... Human Telomere RNA: A Potential Target for Ligand Recognition [作者：Xu, Y,期刊：Current Pharmaceutical Design, 页码：2096-2101 , 文章类型： Review，,卷期：2012年18-14] A recent finding demonstrated that telomere DNA is transcribed into telomeric repeat-containing RNA (referred to as TERRA) in mammalian cells. The existence of TERRA RNA may reveal a new level of regulation and protectio... RNA G-Quadruplexes: G-quadruplexes with "U" Turns [作者：Agarwal, T; Jayaraj, G; Pandey, SP; Agarwala, P; Maiti, S,期刊：Current Pharmaceutical Design, 页码：2102-2111 , 文章类型： Review，,卷期：2012年18-14] G-quadruplexes are non canonical secondary structures held together by Hoogsteen bonded planar guanine quartets formed in G-rich sequences in DNA and RNA. Considerable research over the past three decades has contributed...