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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Peptides in Diagnosis and Therapy [作者：Kanduc, D,期刊：Current Pharmaceutical Design, 页码：747-747 , 文章类型： Editorial Material，,卷期：2012年18-6] Mining PeptideAtlas for Biomarkers and Therapeutics in Human Disease [作者：Killcoyne, S; Deutsch, EW; Boyle, J,期刊：Current Pharmaceutical Design, 页码：748-754 , 文章类型： Review，,卷期：2012年18-6] Mass spectrometry information has long offered the potential of discovering biomarkers that would enable clinicians to diagnose disease, and treat it with targeted therapies. PeptideAtlas currently provides access to lar... Peptides for Therapy and Diagnosis of Alzheimer's Disease [作者：Funke, SA; Willbold, D,期刊：Current Pharmaceutical Design, 页码：755-767 , 文章类型： Review，,卷期：2012年18-6] Alzheimer's disease (AD) is a progressive neurodegenerative disorder with devastating effects. The greatest risk factor to develop AD is age. Today, only symptomatic therapies are available. Additionally, AD can be diagn... Ghrelin and the Brain-gut Axis as a Pharmacological Target for Appetite Control [作者：Seim, I; El-Salhy, M; Hausken, T; Gundersen, D; Chopin, L,期刊：Current Pharmaceutical Design, 页码：768-775 , 文章类型： Review，,卷期：2012年18-6] Appetite regulation is highly complex and involves a large number of orexigenic and anorexigenic peptide hormones. These are small, processed, secreted peptides derived from larger prepropeptide precursors. These peptide... Short Peptide Modules for Enhancing Intestinal Barrier Function [作者：Tanabe, S,期刊：Current Pharmaceutical Design, 页码：776-781 , 文章类型： Review，,卷期：2012年18-6] The intestinal epithelial barrier is indispensable to our immune system. Defects in this barrier function have been observed in intestinal disorders such as inflammatory bowel diseases, food allergies, and celiac disease... Peptides in Oral Diseases [作者：Lucchese, A; Guida, A; Petruzzi, M; Capone, G; Laino, L; Serpico, R,期刊：Current Pharmaceutical Design, 页码：782-788 , 文章类型： Review，,卷期：2012年18-6] The oral cavity is home to numerous viruses and micro-organisms recognized as having a role in various oral diseases as well as in infections in other parts of the body. Indeed, in general a microbial infection underlies... Apelin in the Control of Body Fluid Homeostasis and Cardiovascular Functions [作者：Galanth, C; Hus-Citharel, A; Li, B; Llorens-Cortes, C,期刊：Current Pharmaceutical Design, 页码：789-798 , 文章类型： Review，,卷期：2012年18-6] The discovery of apelin, an endogenous ligand of the orphan APJ receptor is an important advance for fundamental research and clinical medicine. Apelin and its receptor have a wide tissue distribution not only in the bra... Thymosin beta 4 Protein Therapy for Cardiac Repair [作者：Dube, KN; Bollini, S; Smart, N; Riley, PR,期刊：Current Pharmaceutical Design, 页码：799-806 , 文章类型： Review，,卷期：2012年18-6] Clinical interventions leading to improved survival in patients with acute myocardial infarction have, paradoxically, increased the need for cardiac regenerative strategies as more people are living with heart failure. O... Therapeutic Potential of Host Defense Peptides in Antibiotic-resistant Infections [作者：Afacan, NJ; Yeung, ATY; Pena, OM; Hancock, REW,期刊：Current Pharmaceutical Design, 页码：807-819 , 文章类型： Review，,卷期：2012年18-6] The emergence of infections caused by multi-drug resistant (MDR) pathogens pose a major burden to modern healthcare. Exacerbating this issue is the substantial decline in development of new classes of antibiotics by phar... Peptides in Melanoma Therapy [作者：Mocellin, S,期刊：Current Pharmaceutical Design, 页码：820-831 , 文章类型： Review，,卷期：2012年18-6] Peptides derived from tumor associated antigens can be utilized to elicit a therapeutically effective immune response against melanoma in experimental models. However, patient vaccination with peptides - although it is o... Circumscribing the Conformational Peptide Epitope Landscape [作者：Lucchese, G; Calabro, M; Kanduc, D,期刊：Current Pharmaceutical Design, 页码：832-839 , 文章类型： Review，,卷期：2012年18-6] The development of vaccines for new and re-emerging pathologies and infections is based on the ability to define immunogenic epitopes. An immunogenic B-cell peptide epitope is a specific restricted antigen region that is... Pharmacological Modulation of Microparticle Release: New Strategies for the Management of Atherothrombotic Vascular Disorders [作者：Montoro-Garcia, S; Orenes-Pinero, E; Marin, F; Mariano, V; Lip, GYH; Shantsila, E,期刊：Current Pharmaceutical Design, 页码：840-849 , 文章类型： Review，,卷期：2012年18-6] Microparticles (MPs) are submicron vesicles (0.1-1 mu m) shed from the membrane of platelets, monocytes, endothelial cells and other cell types. Abundant clinical evidence relates increased plasma levels of MPs with seve... Antiplatelet Therapy in Atherothrombotic Cardiovascular Diseases for Primary and Secondary Prevention: A Focus on Old and New Antiplatelet Agents [作者：Pamukcu, B; Huber, K; Lip, GYH,期刊：Current Pharmaceutical Design, 页码：850-860 , 文章类型： Review，,卷期：2012年18-6] Aspirin has long been the mainstay of primary and secondary prevention against myocardial infarction and ischemic cerebrovascular events. However, the incremental value of aspirin for primary prevention has recently been...