- Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth, Angiogenesis and Metastasis
[作者：Dhup, S; Dadhich, RK; Porporato, PE; Sonveaux, P,期刊：Current Pharmaceutical Design, 页码：1319-1330 , 文章类型： Review，,卷期：2012年18-10]
- High rate of glycolysis is a metabolic hallmark of cancer. While anaerobic glycolysis promotes energy production under hypoxia, aerobic glycolysis, the Warburg effect, offers a proliferative advantage through redirecting...
- Physiology, Pharmacology and Pathophysiology of the pH Regulatory Transport Proteins NHE1 and NBCn1: Similarities, Differences, and Implications for Cancer Therapy
[作者：Boedtkjer, E; Bunch, L; Pedersen, SF,期刊：Current Pharmaceutical Design, 页码：1345-1371 , 文章类型： Review，,卷期：2012年18-10]
- The Na(+)/H(+)-exchanger 1, NHE1 (SLC9A1) and the electroneutral Na(+), HCO(3)(-)-cotransporter NBCn1 (SLC4A7) are co-expressed in a wide range of tissues. Under normal physiological conditions these transporters play an...
- NHE-1: A Promising Target for Novel Anti-cancer Therapeutics
[作者：Loo, SY; Chang, MKX; Chua, CSH; Kumar, AP; Pervaiz, S; Clement, MV,期刊：Current Pharmaceutical Design, 页码：1372-1382 , 文章类型： Review，,卷期：2012年18-10]
- Among the many factors involved in the maintenance of homeostatic growth is the tight regulation of cellular pH. Intracellular pH of normal cells is maintained within a physiological range thanks to the activity of a num...
- Intracellular Proton Pumps as Targets in Chemotherapy: V-ATPases and Cancer
[作者：Hernandez, A; Serrano-Bueno, G; Perez-Castineira, JR; Serrano, A,期刊：Current Pharmaceutical Design, 页码：1383-1394 , 文章类型： Review，,卷期：2012年18-10]
- Cancer cells show a metabolic shift that makes them overproduce protons; this has the potential to disturb the cellular acid-base homeostasis. However, these cells show cytoplasmic alkalinisation, increased acid extrusio...
- Inhibition of V-ATPase and Carbonic Anhydrases as Interference Strategy with Tumor Acidification Processes
[作者：Perez-Sayans, M; Garcia-Garcia, A; Scozzafava, A; Supuran, CT,期刊：Current Pharmaceutical Design, 页码：1407-1413 , 文章类型： Review，,卷期：2012年18-10]
- Two of the key proteins involved in tumor acidification are the V-ATPase and the tumor-associated carbonic anhydrases (CAs), such as CA IX and XII. Although there are many chemical classes of V-ATPase inhibitors, most of...
- Translational Research of Photodynamic Therapy with Acridine Orange which Targets Cancer Acidity
[作者：Kusuzaki, K; Hosogi, S; Ashihara, E; Matsubara, T; Satonaka, H; Nakamura, T; Matsumine, A; Sudo, A; Uchida, A; Murata, H; Baldini, N; Fais, S; Marunaka, Y,期刊：Current Pharmaceutical Design, 页码：1414-1420 , 文章类型： Review，,卷期：2012年18-10]
- During the past 20 years, we have found that acridine orange (AO) selectively accumulates in musculoskeletal sarcomas in vivo or exerts selective cytocidal effects against sarcoma cells in vitro after illumination of the...
- In Vivo and In Vitro Evaluation of the Therapeutic Potential of Some Turkish Scorzonera Species as Wound Healing Agent
[作者：Suntar, I; Acikara, OB; Citoglu, GS; Keles, H; Ergene, B; Akkol, EK,期刊：Current Pharmaceutical Design, 页码：1421-1433 , 文章类型： Review，,卷期：2012年18-10]
- Wound healing and anti-inflammatory effects of aerial parts and roots of S. acuminata, S. cana var. alpina, S. cana var. jacquiniana, S. cana var. radicosa, S. eriophora, S. laciniata ssp. laciniata, S. suberosa ssp. sub...
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