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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Past, Present and Future in the Treatment of Major Psychotic Disorders [作者：Fountoulakis, KN,期刊：Current Pharmaceutical Design, 页码：1557-1557 , 文章类型： Editorial Material，,卷期：2012年18-12] Basic Pharmacology of NMDA Receptors [作者：Gonda, X,期刊：Current Pharmaceutical Design, 页码：1558-1567 , 文章类型： Review，,卷期：2012年18-12] NMDA receptors are ionotropic receptors mediating glutamatergic neurotransmission and play a role in several basic functions in the central nervous system, from regulating neurodevelopment and synaptic plasticity, learni... Is Dopamine Neurotransmission Altered in Prodromal Schizophrenia? A Review of the Evidence [作者：Bauer, M; Praschak-Rieder, N; Kasper, S; Willeit, M,期刊：Current Pharmaceutical Design, 页码：1568-1579 , 文章类型： Review，,卷期：2012年18-12] It is known that early treatment improves the outcome in patients with schizophrenia. Treatment interventions prior to the onset of frank psychosis hold the promise of even better outcomes. Since schizophrenia typically ... Genetic Data Supporting the NMDA Glutamate Receptor Hypothesis for Schizophrenia [作者：Schwartz, TL; Sachdeva, S; Stahl, SM,期刊：Current Pharmaceutical Design, 页码：1580-1592 , 文章类型： Review，,卷期：2012年18-12] The Dopamine Hypothesis has been the leading theory used to explain the mechanism of the clinical manifestation of schizophrenia symptoms for decades. It is unclear if excess dopaminergic activity is the primary pathophy... Glutamatergic Animal Models of Schizophrenia [作者：Bondi, C; Matthews, M; Moghaddam, B,期刊：Current Pharmaceutical Design, 页码：1593-1604 , 文章类型： Review，,卷期：2012年18-12] Dysregulation of glutamate neurotransmission has been implicated in schizophrenia primarily because antagonists of the n-methyl-d-aspartate (NMDA) subtype of glutamate receptors exacerbate preexisting symptoms of schizop... The Possible Involvement of NMDA Glutamate Receptor in the Etiopathogenesis of Bipolar Disorder [作者：Fountoulakis, KN,期刊：Current Pharmaceutical Design, 页码：1605-1608 , 文章类型： Review，,卷期：2012年18-12] Glutamate is the most abundant excitatory neurotransmitter in the brain and the ionotropic NMDA receptor is one of the major classes of its receptors, thought to play an important role in schizophrenia and mood disorders... Mechanisms of Neutrophil-mediated Disease: Innovative Therapeutic Interventions [作者：Magrone, T; Jirillo, E,期刊：Current Pharmaceutical Design, 页码：1609-1619 , 文章类型： Review，,卷期：2012年18-12] Over recent years, neutrophil functions have extensively been reevaluted. For instance, it has been found that extracellular traps generated by activated neutrophils are able to perform a very effective antimicrobial act... The Mechanism of Carvedilol in Experimental Viral Myocarditis [作者：Li, YC; Ge, LS; Guan, XQ; Lin, JF,期刊：Current Pharmaceutical Design, 页码：1620-1624 , 文章类型： Review，,卷期：2012年18-12] Carvedilol is a nonselective beta-blocker with alpha(1)-adrenergic blocking and antioxidant properties. A number of preclinical experiments and clinical trials have demonstrated that carvedilol provides prominent benefit... A Critical Appraisal of the Functional Evolution of P2Y12 Antagonists as Antiplatelet Drugs [作者：Fayaz, SMA; Rajanikant, GK,期刊：Current Pharmaceutical Design, 页码：1625-1634 , 文章类型： Review，,卷期：2012年18-12] P2Y12 receptor mediated inhibition of platelet aggregation is one of the most explored and exploited pathways in antiplatelet drug therapy to prevent ischemic events in patients undergoing percutaneous coronary intervent... Sympathetic Nervous System Dysfunction in Multiple Sclerosis, Linking Neurodegeneration to a Reduced Response to Therapy [作者：Sternberg, Z,期刊：Current Pharmaceutical Design, 页码：1635-1644 , 文章类型： Review，,卷期：2012年18-12] A lower than normal function of the sympathetic nervous system (SNS) has been identified early in the course of multiple sclerosis (MS) and has been shown to play a role in the pathology of the disease. In addition, the ... Old Wine in a New Bottle: The Warburg Effect and Anticancer Mechanisms of Resveratrol [作者：Muqbil, I; Beck, FWJ; Bao, B; Sarkar, FH; Mohammad, RM; Hadi, SM; Azmi, AS,期刊：Current Pharmaceutical Design, 页码：1645-1654 , 文章类型： Review，,卷期：2012年18-12] Resveratrol found in fruits, vegetables and beverages such as red wine, has been extensively evaluated for its anti-cardiovascular disease and cancer preventive effects. Even though studies have demonstrated its anti-tum... In Vivo Pharmacokinetics, Immunogenicity and Mechanism of PEGylated Anti-tumor Polypeptide [作者：Liu, ZD; Li, WG; Xu, HM; Huang, XF; Pan, L; Ren, YL; Yang, YJ; Li, YB; Pu, CY; Zhang, C,期刊：Current Pharmaceutical Design, 页码：1655-1662 , 文章类型： Review，,卷期：2012年18-12] HM-3, An RGD (Arg-Gly-Asp)-modified polypeptide derived from endostatin, is a potent angiogenesis inhibitor. Its robust inhibitory effects on endothelial cell migration and tumor growth have been demonstrated by activity... Cucurbitacins as Inducers of Cell Death and a Rich Source of Potential Anticancer Compounds [作者：Rios, JL; Andujar, I; Escandell, JM; Giner, RM; Recio, MC,期刊：Current Pharmaceutical Design, 页码：1663-1676 , 文章类型： Review，,卷期：2012年18-12] Triterpenes have been reported to induce cell death. One relevant group of this family of compounds is cucurbitacins, which have been studied as inducers of apoptosis in various cancer cell lines. The most significant me...