- Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications
[作者:Wu, WKK; Wang, GS; Coffelt, SB; Betancourt, AM; Lee, CW; Fan, DM; Wu, KC; Yu, J; Sung, JJY; Cho, CH,期刊:International Journal of Cancer, 页码:1741-1747 , 文章类型: Review,,卷期:2010年127-8]
- Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also mod...
- Effects of estrogen on breast cancer development: role of estrogen receptor independent mechanisms
[作者:Yue, W; Wang, JP; Li, YB; Fan, P; Liu, GJ; Zhang, N; Conaway, M; Wang, HK; Korach, KS; Bocchinfuso, W; Santen, R,期刊:International Journal of Cancer, 页码:1748-1757 , 文章类型: Article,,卷期:2010年127-8]
- Development of breast cancer involves genetic factors as well as lifetime exposure to estrogen. The precise molecular mechanisms whereby estrogens influence breast tumor formation are poorly understood. While estrogen re...
- Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth
[作者:Tang, YX; Li, XB; Liu, ZB; Simoneau, AR; Xie, J; Zi, XL,期刊:International Journal of Cancer, 页码:1758-1768 , 文章类型: Article,,卷期:2010年127-8]
- Limited success has been achieved in extending the survival of patients with metastatic and hormone-refractory prostate cancer (HRPC). There is a strong need for novel agents in the treatment and prevention of HRPC. We h...
- Insights on distinct pathways of thiazolidinediones (PPAR gamma ligand)-promoted apoptosis in TRAIL-sensitive or -resistant malignant urothelial cells
[作者:Plissonnier, ML; Fauconnet, S; Bittard, H; Lascombe, I,期刊:International Journal of Cancer, 页码:1769-1784 , 文章类型: Article,,卷期:2010年127-8]
- Thiazolidinediones, including rosiglitazone and troglitazone, are insulin-sensitizing drugs and high-affinity ligands for the peroxisome proliferator-activated receptor c (PPAR gamma). Apart from their antidiabetic activ...
- Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin
[作者:Pogribny, IP; Filkowski, JN; Tryndyak, VP; Golubov, A; Shpyleva, SI; Kovalchuk, O,期刊:International Journal of Cancer, 页码:1785-1794 , 文章类型: Article,,卷期:2010年127-8]
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- Upregulation of REG I alpha accelerates tumor progression in pancreatic cancer with diabetes
[作者:Zhou, L; Zhang, RF; Wang, LS; Shen, SM; Okamoto, H; Sugawara, A; Xia, L; Wang, XL; Noguchi, N; Yoshikawa, T; Uruno, A; Yao, WY; Yuan, YZ,期刊:International Journal of Cancer, 页码:1795-1803 , 文章类型: Article,,卷期:2010年127-8]
- Diabetes is now generally accepted as a crucial event in the process of pancreatic cancer (PaC). However, molecular mechanisms underlying the relationship between diabetes and PaC are not fully understood. Regenerating g...
- Regulation of HER expression and transactivation in human prostate cancer cells by a targeted cytotoxic bombesin analog (AN-215) and a bombesin antagonist (RC-3095)
[作者:Sotomayor, S; Munoz-Moreno, L; Carmena, MJ; Schally, AV; Sanchez-Chapado, M; Prieto, JC; Bajo, AM,期刊:International Journal of Cancer, 页码:1813-1822 , 文章类型: Article,,卷期:2010年127-8]
- Bombesin (BN) and gastrin-releasing peptide (GRP) have been shown to stimulate the growth of human prostate cancer in vivo and in vitro by mechanisms initiated by binding of the peptide to BN/GRP receptor (GRPR). GRPR is...
- Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization
[作者:Gogvadze, V; Norberg, E; Orrenius, S; Zhivotovsky, B,期刊:International Journal of Cancer, 页码:1823-1832 , 文章类型: Article,,卷期:2010年127-8]
- Release of mitochondrial proteins such as cytochrome c, AIF, Smac/Diablo etc., plays a crucial role in apoptosis induction. A redox-silent analog of vitamin E, a-tocopheryl succinate (alpha-TOS), was shown to stimulate c...
- The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers
[作者:Liang, QY; Ding, JY; Xu, RZ; Xu, ZF; Zheng, S,期刊:International Journal of Cancer, 页码:1833-1843 , 文章类型: Article,,卷期:2010年127-8]
- The psiTPTE22 gene has been designated as a TPTE pseudogene. Our study found that the 5' part of psiTPTE22 has no sequence similarity to TPTE and contains a 3.8-kb human endogenous retrovirus (HERV) element. Because of t...
- ADAM28 is a serological and histochemical marker for non-small-cell lung cancers
[作者:Kuroda, H; Mochizuki, S; Shimoda, M; Chijiiwa, M; Kamiya, K; Izumi, Y; Watanabe, M; Horinouchi, H; Kawamura, M; Kobayashi, K; Okada, Y,期刊:International Journal of Cancer, 页码:1844-1856 , 文章类型: Article,,卷期:2010年127-8]
- ADAM28 (a disintegrin and metalloproteinase 28) is over-expressed in non-small-cell lung cancer (NSCLC) with correlation to cancer cell proliferation, tumor size and lymph node metastasis. The present study was aimed to ...
- Promoter hypomethylation and upregulation of trefoil factors in prostate cancer
[作者:Vestergaard, EM; Nexo, E; Torring, N; Borre, M; Orntoft, TF; Sorensen, KD,期刊:International Journal of Cancer, 页码:1857-1865 , 文章类型: Article,,卷期:2010年127-8]
- Trefoil factors, mucin-associated peptides, are overexpressed in prostate cancer (PC). We hypothesized that promoter methylation contributes to the regulation of trefoil factors (TFF1, TFF2 and TFF3) in human prostate ce...
- Blood leukocyte DNA hypomethylation and gastric cancer risk in a high-risk Polish population
[作者:Hou, LF; Wang, H; Sartori, S; Gawron, A; Lissowska, J; Bollati, V; Tarantini, L; Zhang, FF; Zatonski, W; Chow, WH; Baccarelli, A,期刊:International Journal of Cancer, 页码:1866-1874 , 文章类型: Article,,卷期:2010年127-8]
- Global hypomethylation has been shown to increase genome instability potentially leading to increased cancer risk. We determined whether global methylation in blood leukocyte DNA was associated with gastric cancer in a p...
- Incidence of cancers, ischemic cardiovascular diseases and mortality during 5-year follow-up after stopping antioxidant vitamins and minerals supplements: a postintervention follow-up in the SU.VI.MAX Study
[作者:Hercberg, S; Kesse-Guyot, E; Druesne-Pecollo, N; Touvier, M; Favier, A; Latino-Martel, P; Briancon, S; Galan, P,期刊:International Journal of Cancer, 页码:1875-1881 , 文章类型: Article,,卷期:2010年127-8]
- The Supplementation in Vitamins and Mineral Antioxidants Study was a double-blind, placebo-controlled, randomized trial, in which 12,741 French adults (7,713 women aged 35-60 years and 5,028 men aged 45-60 years) receive...
- Comparison of natural histories of human papillomavirus detected by clinician- and self-sampling
[作者:Moscicki, AB; Widdice, L; Ma, YF; Farhat, S; Miller-Benningfield, S; Jonte, J; Jay, J; de Medina, CG; Hanson, E; Clayton, L; Shiboski, S,期刊:International Journal of Cancer, 页码:1882-1892 , 文章类型: Article,,卷期:2010年127-8]
- New strategies for cervical cancer screening include human papillomavirus (HPV) DNA testing. Using self-testing methods would increase access to testing in both developed and developing countries. The purpose of this stu...
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