- The role of the intravascular microenvironment in spontaneous metastasis development
[作者:Zhang, QB; Yang, M; Shen, JK; Gerhold, LM; Hoffman, RM; Xing, HR,期刊:International Journal of Cancer, 页码:2534-2541 , 文章类型: Article,,卷期:2010年126-11]
- Metastasis is primarily responsible for the morbidity and mortality of cancer. Improved therapeutic outcomes and prognosis depend on improved understanding of mechanisms regulating the establishment of early metastasis. ...
- Glutamate receptor, ionotropic, kainate 2 silencing by DNA hypermethylation possesses tumor suppressor function in gastric cancer
[作者:Wu, CS; Lu, YJ; Li, HP; Hsueh, C; Lu, CY; Leu, YW; Liu, HP; Lin, KH; Huang, THM; Chang, YS,期刊:International Journal of Cancer, 页码:2542-2552 , 文章类型: Article,,卷期:2010年126-11]
- Aberrant DNA methylation is considered a major mechanism for silencing tumor suppressor genes in gastric cancer. We used CpG microarray and differential methylation hybridization strategies to identify potential tumor su...
- Overexpression of IQGAP1 in advanced colorectal cancer correlates with poor prognosis-critical role in tumor invasion
[作者:Hayashi, H; Nabeshima, K; Aoki, M; Hamasaki, M; Enatsu, S; Yamauchi, Y; Yamashita, Y; Iwasaki, H,期刊:International Journal of Cancer, 页码:2563-2574 , 文章类型: Article,,卷期:2010年126-11]
- IQGAP1 is a multifunctional protein involved in actin cytoskeleton assembly and E-cadherin-mediated cell adhesion. We reported previously IQGAP1 overexpression in human colorectal carcinomas especially at the invasion fr...
- Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas
[作者:Gotze, S; Wolter, M; Reifenberger, G; Muller, O; Sievers, S,期刊:International Journal of Cancer, 页码:2584-2593 , 文章类型: Article,,卷期:2010年126-11]
- Aberrant activation of wingless (Wnt) signaling is involved in the pathogenesis of various cancers. Recent studies suggested a role of Wnt signaling in gliomas, the most common primary brain tumors. We investigated 70 gl...
- Amplicons on chromosome 12q13-21 in glioblastoma recurrences
[作者:Fischer, U; Leidinger, P; Keller, A; Folarin, A; Keller, R; Graf, N; Lenhof, HP; Meese, E,期刊:International Journal of Cancer, 页码:2594-2602 , 文章类型: Article,,卷期:2010年126-11]
- There is limited knowledge on the in vivo behavior of amplified regions in human tumors. First evidence indicates that amplicon structures are largely maintained in recurrent tumors. Here, we investigated the fate of amp...
- Betapapillomavirus infection profiles in tissue sets from cutaneous squamous cell-carcinoma patients
[作者:Plasmeijer, EI; Neale, RE; Buettner, PG; de Koning, MNC; ter Schegget, J; Quint, WGV; Green, AC; Feltkamp, MCW,期刊:International Journal of Cancer, 页码:2614-2621 , 文章类型: Article,,卷期:2010年126-11]
- Human papillomaviruses from the genus beta (betaPV) are a possible cause of cutaneous squamous cell carcinoma (SCC). We compared the betaPV infections in SCC and in sets of cutaneous tissues collected from a series of in...
- Novel cancer vaccine based on genes of Salmonella pathogenicity island 2
[作者:Xiong, GS; Husseiny, MI; Song, LP; Erdreich-Epstein, A; Shackleford, GM; Seeger, RC; Jackel, D; Hensel, M; Metelitsa, LS,期刊:International Journal of Cancer, 页码:2622-2634 , 文章类型: Article,,卷期:2010年126-11]
- Although tumors express potentially immunogenic tumor-associated antigens (TAAs), cancer vaccines often fail because of inadequate antigen delivery and/or insufficient activation of innate immunity. Engineering nonpathog...
- High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients
[作者:Frey, DM; Droeser, RA; Viehl, CT; Zlobec, I; Lugli, A; Zingg, U; Oertli, D; Kettelhack, C; Terracciano, L; Tornillo, L,期刊:International Journal of Cancer, 页码:2635-2643 , 文章类型: Article,,卷期:2010年126-11]
- Regulatory T cells (T-reg) inhibit the generation of host-versus-tumor immunity via suppression of tumor-specific effector T-cell responses and development of immune tolerance to neoplastic cells. The transcription facto...
- Detailed examination of lymph nodes improves prognostication in colorectal cancer
[作者:Doekhie, FS; Mesker, WE; Kuppen, PJ; van Leeuwen, GA; Morreau, H; de Bock, GH; Putter, H; Tanke, HJ; van de Velde, CJ; Tollenaar, RA,期刊:International Journal of Cancer, 页码:2644-2652 , 文章类型: Article,,卷期:2010年126-11]
- Up to 30% of stage II patients with curatively resected colorectal cancer (CRC) will develop disease recurrence. We evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining c...
- Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC)
[作者:Albinger-Hegyi, A; Stoeckli, SJ; Schmid, S; Storz, M; Iotzova, G; Probst-Hensch, NM; Rehrauer, H; Tinguely, M; Moch, H; Hegyi, I,期刊:International Journal of Cancer, 页码:2653-2662 , 文章类型: Article,,卷期:2010年126-11]
- Proteins of the lysyl oxidase (LOX) family are important modulators of the extracellular matrix. However, they have an important role in the tumour development as well as in tumour progression. To evaluate the diagnostic...
|