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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共30条记录   Lipid-Protein Correlations in Nanoscale Phospholipid Bilayers Determined by Solid-State Nuclear Magnetic Resonance [作者：Kijac, A; Shih, AY; Nieuwkoop, AJ; Schulten, K; Sligar, SG; Rienstra, CM,期刊：Biochemistry, 页码：9190-9198 , 文章类型： Article，,卷期：2010年49-43] Nanodiscs are examples of discoidal nanoscale lipid protein particles that have been extremely useful for the biochemical and biophysical characterization of membrane proteins. They are discoidal lipid bilayer fragments ... Azole Drugs Trap Cytochrome P450 EryK in Alternative Conformational States [作者：Montemiglio, LC; Gianni, S; Vallone, B; Savino, C,期刊：Biochemistry, 页码：9199-9206 , 文章类型： Article，,卷期：2010年49-43] EryK is a bacterial cytochrome P450 that catalyzes the last hydroxylation occurring during the biosynthetic pathway of erythromycin A in Streptomyces erythraeus. We report the crystal structures of EryK in complex with t... Channel-Opening Kinetic Mechanism for Human Wild-Type GluK2 and the M867I Mutant Kainate Receptor [作者：Han, Y; Wang, CZ; Park, JS; Niu, L,期刊：Biochemistry, 页码：9207-9216 , 文章类型： Article，,卷期：2010年49-43] GluK2 is a kainate receptor subunit that is alternatively spliced at the C-terminus. Previous studies implicated GluK2 in autism. In particular, the methionine-to-isoleucine replacement at amino acid residue 867 (M867I) ... Dynamic Regulation of Fibrinogen: Integrin alpha IIb beta 3 Binding [作者：Hantgan, RR; Stahle, MC; Lord, ST,期刊：Biochemistry, 页码：9217-9225 , 文章类型： Article，,卷期：2010年49-43] This study demonstrates that two orthogonal events regulate integrin alpha IIb beta 3's interactions with fibrinogen, its primary physiological ligand: (1) conformational changes at the alpha IIb-beta 3 interface and (2)... Distance Measurements within a Concatamer of the Plasma Membrane Cl-/HCO3- Exchanger, AEl [作者：Basu, A; Mazor, S; Casey, JR,期刊：Biochemistry, 页码：9226-9240 , 文章类型： Article，,卷期：2010年49-43] AEI, which exists in the erythrocyte plasma membrane as a noncovalent dimer, facilitates transmembrane Cl-/HCO3- exchange. Here a concatamer of AEI (two AEI monomers fused via a two-residue linker to form an intramolecul... Ribozymes and Riboswitches: Modulation of RNA Function by Small Molecules [作者：Zhang, J; Lau, MW; Ferre-D'Amare, AR,期刊：Biochemistry, 页码：9123-9131 , 文章类型： Article，,卷期：2010年49-43] Diverse small molecules interact with catalytic RNAs (ribozymes) as substrates and cofactors, and their intracellular concentrations are sensed by gene-regulatory mRNA domains (riboswitches) that modulate transcription, ... Human Frataxin Is an Allosteric Switch That Activates the Fe-S Cluster Biosynthetic Complex [作者：Tsai, CL; Barondeau, DP,期刊：Biochemistry, 页码：9132-9139 , 文章类型： Article，,卷期：2010年49-43] Cellular depletion of the human protein frataxin is correlated with the neurodegenerative disease Friedreich's ataxia and results in the inactivation of Fe-S cluster proteins. Most researchers agree that frataxin functio... Acetylation of GAGA Factor Modulates Its Interaction with DNA [作者：Aran-Guiu, X; Ortiz-Lombardia, M; Oliveira, E; Costa, CB; Odena, MA; Bellido, D; Bernues, J,期刊：Biochemistry, 页码：9140-9151 , 文章类型： Article，,卷期：2010年49-43] GAGA is a Drosophila transcription factor that shows a high degree of post-translational modification. Here, we show that GAGA factor is acetylated in vivo. Lysine residues K325 and K373 on basic regions BR I and BR3 of ... Thermodynamic Stability and Folding Kinetics of the Major G-Quadruplex and Its Loop Isomers Formed in the Nuclease Hypersensitive Element in the Human c-Myc Promoter: Effect of Loops and Flanking Segments on the Stability of Parallel-Stranded Intramolecular G-Quadruplexes [作者：Hatzakis, E; Okamoto, K; Yang, DZ,期刊：Biochemistry, 页码：9152-9160 , 文章类型： Article，,卷期：2010年49-43] Overexpression of the c-Myc proto-oncogene is associated with a broad spectrum of human cancers. Nuclease hypersensitivity element III1 (NHE III1) of the c-Myc promoter can form transcriptionally active and silenced form... Correlation of Charge, Hydrophobicity, and Structure with Antimicrobial Activity of S1 and MIRIAM Peptides [作者：Leptihn, S; Har, JY; Wohland, T; Ding, JL,期刊：Biochemistry, 页码：9161-9170 , 文章类型： Article，,卷期：2010年49-43] Antimicrobial peptides are key elements of the innate immune system. Many of them interact with membranes of bacteria leading to perturbation of the lipid bilayer and eventually to inactivation of the pathogen. The emerg... Sensing DNA Opening in Transcription Using Quenchable Forster Resonance Energy Transfer [作者：Cordes, T; Santoso, Y; Tomescu, AI; Gryte, K; Hwang, LC; Camara, B; Wigneshweraraj, S; Kapanidis, AN,期刊：Biochemistry, 页码：9171-9180 , 文章类型： Article，,卷期：2010年49-43] Many biological processes, such as gene transcription and replication, involve opening and closing of short regions of double-stranded DNA (dsDNA). Few techniques, however, can study these processes in real time or at th... Analysis of Adenosine A(2)a Receptor Stability: Effects of Ligands and Disulfide Bonds [作者：O'Malley, MA; Naranjo, AN; Lazarova, T; Robinson, AS,期刊：Biochemistry, 页码：9181-9189 , 文章类型： Article，,卷期：2010年49-43] G protein-coupled receptors (GPCRs) constitute the largest family of integral membrane proteins present in all eukaryotic cells, yet relatively little information about their structure, folding, and stability has been pu... Reduction Kinetics of a Flavin Oxidoreductase LuxG from Photobacterium leiognathi (TH1): Half-Sites Reactivity [作者：Nijvipakul, S; Ballou, DP; Chaiyen, P,期刊：Biochemistry, 页码：9241-9248 , 文章类型： Article，,卷期：2010年49-43] Bacterial bioluminescence is a phenomenon resulting from the reaction of a two-component FMN-dependent aldehyde monooxygenase system, which comprises a bacterial luciferase and a flavin reductase. Bacterial luciferase (L... Multiple Turnovers of the Nicotino-Enzyme PdxB Require alpha-Keto Acids as Cosubstrates [作者：Rudolph, J; Kim, J; Copley, SD,期刊：Biochemistry, 页码：9249-9255 , 文章类型： Article，,卷期：2010年49-43] PdxB catalyzes the second step in the biosynthesis of pyridoxal phosphate by oxidizing 4-phospho-D-erythronate (4PE) to 2-oxo-3-hydroxy-4-phosphobutanoate (OHPB) with concomitant reduction of NAD(+) to NADH. PdxB is a ni... Assessing Energetic Contributions to Binding from a Disordered Region in a Protein-Protein Interaction [作者：Cho, S; Swaminathan, CP; Bonsor, DA; Kerzic, MC; Guan, R; Yang, JY; Kieke, MC; Andersen, PS; Kranz, DM; Mariuzza, RA; Sundberg, EJ,期刊：Biochemistry, 页码：9256-9268 , 文章类型： Article，,卷期：2010年49-43] Many functional proteins are at least partially disordered prior to binding. Although the structural transitions upon binding of disordered protein regions can influence the affinity and specificity of protein complexes,... Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity [作者：Weeks, AM; Coyle, SM; Jinek, M; Doudna, JA; Chang, MCY,期刊：Biochemistry, 页码：9269-9279 , 文章类型： Article，,卷期：2010年49-43] We have initiated a broad-based program aimed at understanding the molecular basis of fluorine specificity in enzymatic systems, and in this context, we report crystallographic and biochemical studies on a fluoroacetyl-c...