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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共26条记录   Conformational Changes in the G Protein-Coupled Receptor Rhodopsin Revealed by Histidine Hydrogen-Deuterium Exchange [作者：Lodowski, DT; Palczewski, K; Miyagi, M,期刊：Biochemistry, 页码：9425-9427 , 文章类型： Article，,卷期：2010年49-44] G protein-coupled receptors (GPCRs) are activated by ligand binding, allowing extracellular signals to be efficiently transmitted through the membrane to the G protein recognition site, 40 angstrom away. Utilizing His re... Probing the Folding Intermediate of Bacillus subtilis RNase P Protein by Nuclear Magnetic Resonance [作者：Chang, YC; Franch, WR; Oas, TG,期刊：Biochemistry, 页码：9428-9437 , 文章类型： Article，,卷期：2010年49-44] Protein folding intermediates are often imperative for overall folding processes and consequent biological functions. However, the low population and transient nature of the intermediate states often hinder their biochem... Inhibition of Chromatin Remodeling by Polycomb Group Protein Posterior Sex Combs Is Mechanistically Distinct from Nucleosome Binding [作者：Lo, SM; Francis, NJ,期刊：Biochemistry, 页码：9438-9448 , 文章类型： Article，,卷期：2010年49-44] Polycomb Group (PcG) proteins are essential regulators of development that maintain gene silencing in Drosophila and mammals through alterations of chromatin structure. One key PcG protein, Posterior Sex Combs (PSC), is ... Locked onto the Target: Increasing the Efficiency of Antagomirzymes Using Locked Nucleic Acid Modifications [作者：Kaur, H; Scaria, V; Maiti, S,期刊：Biochemistry, 页码：9449-9456 , 文章类型： Article，,卷期：2010年49-44] This study highlights the effect of incorporation of locked nucleic acid (LNA) on improving the functional efficacy of DNAzymes against microRNAs (antagomirzymes). DNAzymes were designed against two different sites of mi... Structural Characterization of GNNQQNY Amyloid Fibrils by Magic Angle Spinning NMR [作者：van der Wel, PCA; Lowandowski, JR; Griffin, RG,期刊：Biochemistry, 页码：9457-9469 , 文章类型： Article，,卷期：2010年49-44] Several human diseases are associated with the formation of am bid aggregates. but experimental characterization of these amyloid fibrils and their oligomeric precursors has remained challenging. Experimental and computa... TAT Fusion Protein Transduction into Isolated Mitochondria Is Accelerated by Sodium Channel Inhibitors [作者：Rayapureddi, JP; Tomamichel, WJ; Walton, ST; Payne, RM,期刊：Biochemistry, 页码：9470-9479 , 文章类型： Article，,卷期：2010年49-44] Stringent control of ion and protein transport across the mitochondrial membranes is required to maintain mitochondrial function and biogenesis. In particular, the inner mitochondrial membrane is generally impermeable to... Ion Binding to KcsA: Implications in Ion Selectivity and Channel Gating [作者：Renart, ML; Triano, I; Poveda, JA; Encinar, JA; Fernandez, AM; Ferrer-Montiel, AV; Gomez, J; Ros, JMG,期刊：Biochemistry, 页码：9480-9487 , 文章类型： Article，,卷期：2010年49-44] Binding of K+ and Na+ to the potassium channel KcsA has been characterized from the stabilization observed in the heat-induced denaturation of the protein as the ion concentration is increased. KcsA thermal denaturation ... The alpha-Helical C-Terminal Domain of Full-Length Recombinant PrP Converts to an In-Register Parallel beta-Sheet Structure in PrP Fibrils: Evidence from Solid State Nuclear Magnetic Resonance [作者：Tycko, R; Savtchenko, R; Ostapchenko, VG; Makarava, N; Baskakov, IV,期刊：Biochemistry, 页码：9488-9497 , 文章类型： Article，,卷期：2010年49-44] We report the results of solid state nuclear magnetic resonance (NMR) measurements on amyloid fibrils formed by the full-length prion protein PrP (residues 23-231, Syrian hamster sequence). Measurements of intermolecular... Phospholipid Hydrolysis Caused by Clostridium perfringens alpha-Toxin Facilitates the Targeting of Perfringolysin O to Membrane Bilayers [作者：Moe, PC; Heuck, AP,期刊：Biochemistry, 页码：9498-9507 , 文章类型： Article，,卷期：2010年49-44] Clostridium perfringens causes gas gangrene and gastrointestinal disease in humans. These pathologies are mediated by potent extracellular protein toxins, particularly alpha-toxin and perfringolysin O (PFO). While alpha-... Serum Amyloid A Activates Peroxisome Proliferator-Activated Receptor gamma through Extracellularly Regulated Kinase 1/2 and COX-2 Expression in Hepatocytes [作者：Li, HZ; Zhao, YL; Zhou, SL; Heng, CK,期刊：Biochemistry, 页码：9508-9517 , 文章类型： Article，,卷期：2010年49-44] Serum amyloid A (SAA) is an acute phase protein whose level of expression increases markedly during bacterial infection, tissue damage, and inflammation. The potential beneficial roles of SAA include its involvement in r... Monovalent Interactions of Galectin-1 [作者：Salomonsson, E; Larumbe, A; Tejler, J; Tullberg, E; Rydberg, H; Sundin, A; Khabut, A; Frejd, T; Lobsanov, YD; Rini, JM; Nilsson, UJ; Leffler, H,期刊：Biochemistry, 页码：9518-9532 , 文章类型： Article，,卷期：2010年49-44] Galectin-1, beta-galactoside binding lectin involved in immunoregulation and cancer, binds natural and many synthetic multivalent glycoconjugates with an apparent glycoside cluster effect, that is, affinity above and bey... The Association-Dissociation Behavior of the ApoE Proteins: Kinetic and Equilibrium Studies [作者：Garai, K; Frieden, C,期刊：Biochemistry, 页码：9533-9541 , 文章类型： Article，,卷期：2010年49-44] The apolipoprotein E family consists of three major protein isoforms: apolipoprotein E4 (ApoE4), ApoE3, and ApoE2. The isoforms, which contain 299 residues, differ only by single-amino acid changes, but of the three, onl... Steady-State Kinetic Mechanism and Reductive Half-Reaction of D-Arginine Dehydrogenase from Pseudomonas aeruginosa [作者：Yuan, H; Fu, G; Brooks, PT; Weber, I; Gadda, G,期刊：Biochemistry, 页码：9542-9550 , 文章类型： Article，,卷期：2010年49-44] D-Arginine dehydrogenase from Pseudomonas aeruginosa catalyzes the oxidation of P-arginine to iminoarginine, which is hydrolyzed in solution to ketoarginine and ammonia. In the present study, we have genetically engineer... Myristate Exposure in the Human Immunodeficiency Virus Type 1 Matrix Protein Is Modulated by pH [作者：Fledderman, EL; Fujii, K; Ghanam, RH; Waki, K; Prevelige, PE; Freed, EO; Saad, JS,期刊：Biochemistry, 页码：9551-9562 , 文章类型： Article，,卷期：2010年49-44] Human immunodeficiency virus type 1 (HIV-1) encodes a polypeptide called Gag that is capable of forming virus-like particles (VLPs) in vitro in the absence of other cellular or viral constituents. During the late phase o... Troponin in both Smooth and Striated Muscles of Ascidian Ciona intestinalis Functions as a Ca2+-Dependent Accelerator of Actin-Myosin Interaction [作者：Ohshiro, K; Obinata, T; Dennisson, JG; Ogasawara, M; Sato, N,期刊：Biochemistry, 页码：9563-9571 , 文章类型： Article，,卷期：2010年49-44] Troponin, a Ca2+-dependent regulator of muscle contraction, acts as an inhibitor of the actin myosin interaction in the absence of Ca2+ during contraction in vertebrate striated muscle. However, variation has been observ... CHOBIMALT: A Cholesterol-Based Detergent [作者：Howell, SC; Mittal, R; Huang, LJ; Travis, B; Breyer, RM; Sanders, CR,期刊：Biochemistry, 页码：9572-9583 , 文章类型： Article，,卷期：2010年49-44] Cholesterol and its hemisuccinate and sulfate derivatives are widely used in studies of purified membrane proteins but are difficult to solubilize in aqueous solution, even in the presence of detergent micelles. Other ch...