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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共22条记录   Preparation and Characterization of Neurotoxic Tau Oligomers [作者：Lasagna-Reeves, CA; Castillo-Carranza, DL; Guerrero-Munoz, MJ; Jackson, GR; Kayed, R,期刊：Biochemistry, 页码：10039-10041 , 文章类型： Article，,卷期：2010年49-47] Tau aggregation is a pathological hallmark of Alzheimer's disease, Parkinson's disease, and many other neurodegenerative disorders known as tauopathies. Tau aggregates take on many forms, and their formation is a multist... Enzymatic Ring Opening of an Iron Corrole by Plant-Type Heme Oxygenases: Unexpected Substrate and Protein Selectivities [作者：Gisk, B; Bregier, F; Kruger, RA; Broring, M; Frankenberg-Dinkel, N,期刊：Biochemistry, 页码：10042-10044 , 文章类型： Article，,卷期：2010年49-47] Heme oxygenases are widely distributed enzymes involved in the oxidative cleavage of the heme macrocycle that yields the open-chain tetrapyrrole biliverdin IX, CO, and iron. For the first time, two regioisomeric iron cor... A pH-Dependent Conformational Ensemble Mediates Proton Transport through the Influenza A/M2 Protein [作者：Polishchuk, AL; Lear, JD; Ma, CL; Lamb, RA; Pinto, LH; DeGrado, WF,期刊：Biochemistry, 页码：10061-10071 , 文章类型： Article，,卷期：2010年49-47] The influenza A/M2 protein exhibits inwardly rectifying, pH-activated proton transport that saturates at low pH. A comparison of high-resolution structures of the transmembrane domain at high and low pH suggests that pH-... Structural Origins of Nitroxide Side Chain Dynamics on Membrane Protein alpha-Helical Sites [作者：Kroncke, BM; Horanyi, PS; Columbus, L,期刊：Biochemistry, 页码：10045-10060 , 文章类型： Article，,卷期：2010年49-47] Understanding the structure and dynamics of membrane proteins in their native, hydrophobic environment is important to understanding how these proteins function. EPR spectroscopy in combination with site-directed spin la... Pivotal Roles of Three Conserved Carboxyl Residues of the NuoC (30k) Segment in the Structural Integrity of Proton-Translocating NADH-Quinone Oxidoreductase from Escherichia coli [作者：Castro-Guerrero, N; Sinha, PK; Torres-Bacete, J; Matsuno-Yagi, A; Yagi, T,期刊：Biochemistry, 页码：10072-10080 , 文章类型： Article，,卷期：2010年49-47] The prokaryotic proton-translocating NADH-quinone oxidoreductase (NDH-1) is an L-shaped membrane-bound enzyme that contains 14 subunits (NuoA-NuoN or Nqo1-Nqo14). All subunits have their counterparts in the eukaryotic en... A Specific Interaction of L-Tryptophan with CO of CO-Bound Indoleamine 2,3-Dioxygenase Identified by Resonance Raman Spectroscopy [作者：Yanagisawa, S; Sugimoto, H; Shiro, Y; Ogura, T,期刊：Biochemistry, 页码：10081-10088 , 文章类型： Article，,卷期：2010年49-47] Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme which catalyzes dioxygenation of L-Trp (tryptophan), yielding N-formylkynurenine. IDO thus plays a key role in L-Trp catabolism in mammals. In the present study, resonan... Photosensitivities of Rhodopsin Mutants with a Displaced Counterion [作者：Tsutsui, K; Shichida, Y,期刊：Biochemistry, 页码：10089-10097 , 文章类型： Article，,卷期：2010年49-47] Visual pigments consist of a protein moiety opsin and an 11-cis-retinal chromophore that is covalently bound to the opsin via a Schiff base linkage. They have a high photosensitivity, which can be attributed to the high ... Water Oxidation by Photosystem II: H2O-D2O Exchange and the Influence of pH Support Formation of an Intermediate by Removal of a Proton before Dioxygen Creation [作者：Gerencser, L; Dau, H,期刊：Biochemistry, 页码：10098-10106 , 文章类型： Article，,卷期：2010年49-47] Understanding the chemistry of photosynthetic water oxidation requires deeper insight into the interrelation between electron transfer (ET) and proton relocations. In photosystem II membrane particles, the redox transiti... The Neutral Lipid Composition Present in the Digestive Vacuole of Plasmodium falciparum Concentrates Heme and Mediates beta-Hematin Formation with an Unusually Low Activation Energy [作者：Hoang, AN; Sandlin, RD; Omar, A; Egan, TJ; Wright, DW,期刊：Biochemistry, 页码：10107-10116 , 文章类型： Article，,卷期：2010年49-47] In eukaryotic cells, neutral lipids serve as major energy storage molecules; however, in Plasmodium falciparum, a parasite responsible for causing malaria in humans, neutral lipids may have other functions during the int... beta-Propeller Phytase Hydrolyzes Insoluble Ca2+-Phytate Salts and Completely Abrogates the Ability of Phytate To Chelate Metal Ions [作者：Kim, OH; Kim, YO; Shim, JH; Jung, YS; Jung, WJ; Choi, WC; Lee, H; Lee, SJ; Kim, KK; Auh, JH; Kim, H; Kim, JW; Oh, TK; Oh, BC,期刊：Biochemistry, 页码：10216-10227 , 文章类型： Article，,卷期：2010年49-47] Phytate is an antinutritional factor that influences the bioavailability of essential minerals by forming complexes with them and converting them into insoluble salts. To further our understanding of the chemistry of phy... Impact of Base Analogues within a CpG Dinucleotide on the Binding of DNA by the Methyl-Binding Domain of MeCP2 and Methylation by DNMT1 [作者：Lao, VV; Darwanto, A; Sowers, LC,期刊：Biochemistry, 页码：10228-10236 , 文章类型： Article，,卷期：2010年49-47] The epigenetic control of transcription requires the selective recognition of methylated CpG dinucleotides by methylation-sensitive sequence-specific DNA binding proteins. In order to probe the mechanism of selective int... The Effect of Asp-His-Ser/Thr-Trp Tetrad on the Thermostability of WD40-Repeat Proteins [作者：Wu, XH; Chen, RC; Gao, Y; Wu, YD,期刊：Biochemistry, 页码：10237-10245 , 文章类型： Article，,卷期：2010年49-47] We recently found that Asp-His-Ser/Thr-Trp hydrogen-bonded tetrads are widely and uniquely present in the WD40-repeat proteins. WDR5 protein is a seven WD40-repeat propeller with five such tetrads. To explore the effect ... A Comparison of Methanobactins from Methylosinus trichosporium OB3b and Methylocystis Strain SB2 Predicts Methanobactins Are Synthesized from Diverse Peptide Precursors Modified To Create a Common Core for Binding and Reducing Copper Ions [作者：Krentz, BD; Mulheron, HJ; Semrau, JD; DiSpirito, AA; Bandow, NL; Haft, DH; Vuilleumier, S; Murrell, JC; McEllistrem, MT; Hartsel, SC; Gallagher, WH,期刊：Biochemistry, 页码：10117-10130 , 文章类型： Article，,卷期：2010年49-47] Methanobactins (mb) are low-molecular mass, copper-binding molecules secreted by most methanotrophic bacteria. These molecules have been identified for a number of methanotrophs, but only the one produced by Methylosinus... A Novel DNA Topoisomerase I Inhibitor with Different Mechanism from Camptothecin Induces G2/M Phase Cell Cycle Arrest to K562 Cells [作者：Wu, N; Wu, XW; Agama, K; Pommier, Y; Du, J; Li, D; Gu, LQ; Huang, ZS; An, LK,期刊：Biochemistry, 页码：10131-10136 , 文章类型： Article，,卷期：2010年49-47] DNA topoisomerase I (Top 1) is an essential nuclear enzyme and a validated target for anticancer agent screening. In a previous study, we found that indolizinoquinoline-5,12-dione derivatives show significant biological ... Mass Spectrometric Identification of Phosphorylation Sites in Guanylyl Cyclase A and B [作者：Yoder, AR; Stone, MD; Griffin, TJ; Potter, LR,期刊：Biochemistry, 页码：10137-10145 , 文章类型： Article，,卷期：2010年49-47] Guanylyl cyclase A and B (GC-A and GC-B) are transmembrane guanylyl cyclase receptors that mediate the physiologic effects of natriuretic peptides. Some sites of phosphorylation are known for rat GC-A and GC-B, but no ph... p67/MetAP2 Suppresses K-RasV12-Mediated Transformation of NIH3T3 Mouse Fibroblasts in Culture and in Athymic Mice [作者：Majumdar, A; Ghosh, A; Datta, S; Prudner, BC; Datta, B,期刊：Biochemistry, 页码：10146-10157 , 文章类型： Article，,卷期：2010年49-47] In many tumor cells, the activation and activity of extracellular signal-regulated kinases (ERK1/2) are very high because of the constitutive activation of the Ras-mediated signaling pathway. Here, we ectopically express...