- The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove
[作者：Stefl, R; Oberstrass, FC; Hood, JL; Jourdan, M; Zimmermann, M; Skrisovska, L; Maris, C; Peng, L; Hofr, C; Emeson, RB; Allain, FHT,期刊：Cell, 页码：225-237 , 文章类型： Article，,卷期：2010年143-2]
- Sequence-dependent recognition of dsDNA-binding proteins is well understood, yet sequence-specific recognition of dsRNA by proteins remains largely unknown, despite their importance in RNA maturation pathways. Adenosine ...
- The Exon Junction Complex Controls the Splicing of mapk and Other Long Intron-Containing Transcripts in Drosophila
[作者：Ashton-Beaucage, D; Udell, CM; Lavoie, H; Baril, C; Lefrancois, M; Chagnon, P; Gendron, P; Caron-Lizotte, O; Bonneil, E; Thibault, P; Therrien, M,期刊：Cell, 页码：251-262 , 文章类型： Article，,卷期：2010年143-2]
- Signaling pathways are controlled by a vast array of posttranslational mechanisms. By contrast, little is known regarding the mechanisms that regulate the expression of their core components. We conducted an RNAi screen ...
- Structural Basis for Actin Assembly, Activation of ATP Hydrolysis, and Delayed Phosphate Release
[作者：Murakami, K; Yasunaga, T; Noguchi, TQP; Gomibuchi, Y; Ngo, KX; Uyeda, TQP; Wakabayashi, T,期刊：Cell, 页码：275-287 , 文章类型： Article，,卷期：2010年143-2]
- Assembled actin filaments support cellular signaling, intracellular trafficking, and cytokinesis. ATP hydrolysis triggered by actin assembly provides the structural cues for filament turnover in vivo. Here, we present th...
- TGF-beta and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance
[作者：Luo, SJ; Kleemann, GA; Ashraf, JM; Shaw, WM; Murphy, CT,期刊：Cell, 页码：299-312 , 文章类型： Article，,卷期：2010年143-2]
- Reproductive cessation is perhaps the earliest aging phenotype that humans experience. Similarly, reproduction of Caenorhabditis elegans ceases in midadulthood. Although somatic aging has been studied in both worms and h...
- A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs
[作者：Kim, J; Woo, AJ; Chu, JL; Snow, JW; Fujiwara, Y; Kim, CG; Cantor, AB; Orkin, SH,期刊：Cell, 页码：313-324 , 文章类型： Article，,卷期：2010年143-2]
- c-Myc (Myc) is an important transcriptional regulator in embryonic stem (ES) cells, somatic cell reprogramming, and cancer. Here, we identify a Myc-centered regulatory network in ES cells by combining protein-protein and...
- Insider Influence on ErbB Activity
[作者：Shilo, BZ,期刊：Cell, 页码：181-182 , 文章类型： Article，,卷期：2010年143-2]
- The receptor tyrosine kinase ErbB is activated by ligand-induced dimerization, leading to transphosphorylation of the cytoplasmic kinase domains. Bill et al. (2010) now demonstrate that transphosphorylation can be modula...
- Chromatin in Multicolor
[作者：Schubeler, D,期刊：Cell, 页码：183-184 , 文章类型： Article，,卷期：2010年143-2]
- Chromatin consists of DNA and a large number of associated proteins. Filion et al. (2010) provide a genome-wide analysis of the location of 53 chromatin proteins in Drosophila, revealing important principles underlying c...
- The Myc Connection: ES Cells and Cancer
[作者：Rothenberg, ME; Clarke, MF; Diehn, M,期刊：Cell, 页码：184-186 , 文章类型： Article，,卷期：2010年143-2]
- Gene profiling experiments have revealed similarities between cancer and embryonic stem (ES) cells. Kim et al. (2010) dissect the gene expression signature of ES cells into three functional modules and find that the Myc ...
- Emerging Role of ISG15 in Antiviral Immunity
[作者：Skaug, B; Chen, ZJJ,期刊：Cell, 页码：187-190 , 文章类型： Review，,卷期：2010年143-2]
- Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we...
- Biological Applications of Protein Splicing
[作者：Vila-Perello, M; Muir, TW,期刊：Cell, 页码：191-200 , 文章类型： Editorial Material，,卷期：2010年143-2]
- Protein splicing is a naturally occurring process in which a protein editor, called an intein, performs a molecular disappearing act by cutting itself out of a host protein in a traceless manner. In the two decades since...
- Cytohesins Are Cytoplasmic ErbB Receptor Activators
[作者：Bill, A; Schmitz, A; Albertoni, B; Song, JN; Heukamp, LC; Walrafen, D; Thorwirth, F; Verveer, PJ; Zimmer, S; Meffert, L; Schreiber, A; Chatterjee, S; Thomas, RK; Ullrich, RT; Lang, T; Famulok, M,期刊：Cell, 页码：201-211 , 文章类型： Article，,卷期：2010年143-2]
- Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. H...
- Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells
[作者：Filion, GJ; van Bemmel, JG; Braunschweig, U; Talhout, W; Kind, J; Ward, LD; Brugman, W; de Castro, IJ; Kerkhoven, RM; Bussemaker, HJ; van Steensel, B,期刊：Cell, 页码：212-224 , 文章类型： Article，,卷期：2010年143-2]
- Chromatin is important for the regulation of transcription and other functions, yet the diversity of chromatin composition and the distribution along chromosomes are still poorly characterized. By integrative analysis of...
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