- Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors
[作者：Ieda, M; Fu, JD; Delgado-Olguin, P; Vedantham, V; Hayashi, Y; Bruneau, BG; Srivastava, D,期刊：Cell, 页码：375-386 , 文章类型： Article，,卷期：2010年142-3]
- The reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) raises the possibility that a somatic cell could be reprogrammed to an alternative differentiated fate without first becoming a stem/progenitor c...
- Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models
[作者：Ittner, LM; Ke, YD; Delerue, F; Bi, MA; Gladbach, A; van Eersel, J; Wolfing, H; Chieng, BC; Christie, MJ; Napier, IA; Eckert, A; Staufenbiel, M; Hardeman, E; Gotz, J,期刊：Cell, 页码：387-397 , 文章类型： Article，,卷期：2010年142-3]
- Alzheimer's disease (AD) is characterized by amyloid-beta (A beta) and tau deposition in brain. It has emerged that A beta toxicity is tau dependent, although mechanistically this link remains unclear. Here, we show that...
- Single-Stranded DNA Transposition Is Coupled to Host Replication
[作者：Bao, TH; Pastemak, C; Siguier, P; Guynet, C; Hickman, AB; Dyda, F; Sommer, S; Chandler, M,期刊：Cell, 页码：398-408 , 文章类型： Article，,卷期：2010年142-3]
- DNA transposition has contributed significantly to evolution of eukaryotes and prokaryotes. Insertion sequences (ISs) are the simplest prokaryotic trans-posons and are divided into families on the basis of their organiza...
- A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
[作者：Huarte, M; Guttman, M; Feldser, D; Garber, M; Koziol, MJ; Kenzelmann-Broz, D; Khalil, AM; Zuk, O; Amit, I; Rabani, M; Attardi, LD; Regev, A; Lander, ES; Jacks, T; Rinn, JL,期刊：Cell, 页码：409-419 , 文章类型： Article，,卷期：2010年142-3]
- Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we ...
- A Minimal Midzone Protein Module Controls Formation and Length of Antiparallel Microtubule Overlaps
[作者：Bieling, P; Telley, IA; Surrey, T,期刊：Cell, 页码：420-432 , 文章类型： Article，,卷期：2010年142-3]
- During cell division, microtubules are arranged in a large bipolar structure, the mitotic spindle, to segregate the duplicated chromosomes. Antiparallel microtubule overlaps in the spindle center are essential for establ...
- Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein
[作者：Subramanian, R; Wilson-Kubalek, EM; Arthur, CP; Bick, MJ; Campbell, EA; Darst, SA; Milligan, RA; Kapoor, TM,期刊：Cell, 页码：433-443 , 文章类型： Article，,卷期：2010年142-3]
- Formation of microtubule architectures, required for cell shape maintenance in yeast, directional cell expansion in plants and cytokinesis in eukaryotes, depends on antiparallel microtubule crosslinking by the conserved ...
- PNPASE Regulates RNA Import into Mitochondria
[作者：Wang, G; Chen, HW; Oktay, Y; Zhang, J; Allen, EL; Smith, GM; Fan, KC; Hong, JS; French, SW; McCaffery, JM; Lightowlers, RN; Morse, HC; Koehler, CM; Teitell, MA,期刊：Cell, 页码：456-467 , 文章类型： Article，,卷期：2010年142-3]
- RNA import into mammalian mitochondria is considered essential for replication, transcription, and translation of the mitochondrial genome but the pathway(s) and factors that control this import are poorly understood. Pr...
- Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1
[作者：Hobbs, RM; Seandel, M; Falciatori, I; Rafii, S; Pandolfi, PP,期刊：Cell, 页码：468-479 , 文章类型： Article，,卷期：2010年142-3]
- Hyperactivity of mTORC1, a key mediator of cell growth, leads to stem cell depletion, although the underlying mechanisms are poorly defined. Using spermatogonial progenitor cells (SPCs) as a model system, we show that mT...
- A MAP for Bundling Microtubules
[作者：Walczak, CE; Shaw, SL,期刊：Cell, 页码：364-367 , 文章类型： Review，,卷期：2010年142-3]
- Microtubules assemble into arrays of bundled filaments that are critical for multiple steps in cell division, including anaphase and cytokinesis. Recent structural and functional studies, including two papers in this iss...
|