- Porcine glutathione transferase Alpha 2-2 is a human GST A3-3 analogue that catalyses steroid double-bond isomerization
[作者：Fedulova, N; Raffalli-Mathieu, F; Mannervik, B,期刊：Biochemical Journal, 页码：159-167 , 文章类型： Article，,卷期：2010年431-Part 1]
- A primary role of GSTs (glutathione transferases) is detoxication of electrophilic compounds. In addition to this protective function, hGST (human GST) A3-3, a member of the Alpha class of soluble GSTs, has prominent ste...
- Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae
[作者：Cowart, LA; Gandy, JL; Tholanikunnel, B; Hannun, YA,期刊：Biochemical Journal, 页码：31-38 , 文章类型： Article，,卷期：2010年431-Part 1]
- Recent work, especially in the yeast Saccharomyces cerevisiae, has demonstrated that mRNA movement from active translation to cytoplasmic granules, termed mRNA'p-bodies' (processing bodies), occurs in concert with the re...
- Role of a PA14 domain in determining substrate specificity of a glycoside hydrolase family 3 beta-glucosidase from Kluyveromyces marxianus
[作者：Yoshida, E; Hidaka, M; Fushinobu, S; Koyanagi, T; Minami, H; Tamaki, H; Kitaoka, M; Katayama, T; Kumagai, H,期刊：Biochemical Journal, 页码：39-49 , 文章类型： Article，,卷期：2010年431-Part 1]
- beta-Glucosidase from Kluyveromyces marxianus (KmBgII) belongs to the GH3 (glycoside hydrolase family 3). The enzyme is particularly unusual in that a PA14 domain (pf07691), for which a carbohydrate-binding role has been...
- Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors
[作者：Drinkwater, N; Vu, H; Lovell, KM; Criscione, KR; Collins, BM; Prisinzano, TE; Poulsen, SA; McLeish, MJ; Grunewald, GL; Martin, JL,期刊：Biochemical Journal, 页码：51-61 , 文章类型： Article，,卷期：2010年431-Part 1]
- CNS (central nervous system) adrenaline (epinephrine) is implicated in a wide range of physiological and pathological conditions. PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis...
- Kinetic and thermodynamic resolution of the interactions between sulfite and the pentahaem cytochrome NrfA from Escherichia coil
[作者：Kemp, GL; Clarke, TA; Marritt, SJ; Lockwood, C; Poock, SR; Hemmings, AM; Richardson, DJ; Cheesman, MR; Butt, JN,期刊：Biochemical Journal, 页码：73-80 , 文章类型： Article，,卷期：2010年431-Part 1]
- NrfA is a pentahaem cytochrome present in a wide-range of gamma-, delta- and epsilon-proteobacteria. Its nitrite and nitric oxide reductase activities have been studied extensively and contribute to respiratory nitrite a...
- Identification and characterization of PRG-1 as a neuronal calmodulin-binding protein
[作者：Tokumitsu, H; Hatano, N; Tsuchiya, M; Yurimoto, S; Fujimoto, T; Ohara, N; Kobayashi, R; Sakagami, H,期刊：Biochemical Journal, 页码：81-91 , 文章类型： Article，,卷期：2010年431-Part 1]
- Intracellular Ca2+-dependent cellular responses are often mediated by the ubiquitous protein CaM (calmodulin), which, upon binding Ca2+, can interact with and alter the function of numerous proteins. In the present study...
- Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X
[作者：Shi, XL; Opi, S; Lugari, A; Restouin, A; Coursindel, T; Parrot, I; Perez, J; Madore, E; Zimmermann, P; Corbeil, J; Huang, MD; Arold, ST; Collette, Y; Morelli, X,期刊：Biochemical Journal, 页码：93-102 , 文章类型： Article，,卷期：2010年431-Part 1]
- SFKs (Src family kinases) are central regulators of many signalling pathways. Their functions are tightly regulated through SH (Src homology) domain-mediated protein protein interactions. A yeast two-hybrid screen using ...
- Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain
[作者：Chiu-Ugalde, J; Theilig, F; Behrends, T; Drebes, J; Sieland, C; Subbarayal, P; Kohrle, J; Hammes, A; Schomburg, L; Schweizer, U,期刊：Biochemical Journal, 页码：103-111 , 文章类型： Article，,卷期：2010年431-Part 1]
- Distribution of selenium (Se) within the mammalian body is mediated by SePP (selenoprotein P), an Se-rich glycoprotein secreted by hepatocytes. Genetic and biochemical evidence indicate that the endocytic receptors ApoER...
- Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
[作者：Lim, NH; Kashiwagi, M; Visse, R; Jones, J; Enghild, JJ; Brew, K; Nagase, H,期刊：Biochemical Journal, 页码：113-122 , 文章类型： Article，,卷期：2010年431-Part 1]
- We have reported previously that reactive-site mutants of N-TIMP-3 [N-terminal inhibitory domain of TIMP-3 (tissue inhibitor of metalloproteinases 3)] modified at the N-terminus, selectively inhibited ADAM 17 (a disinteg...
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