- Formation of transient dimers by a retroviral protease
[作者：Hartl, MJ; Schweimer, K; Reger, MH; Schwarzinger, S; Bodem, J; Rosch, P; Wohrl, BM,期刊：Biochemical Journal, 页码：197-203 , 文章类型： Article，,卷期：2010年427-Part 2]
- Retroviral proteases have been shown previously to be only active as homodimers. They are essential to form the separate and active proteins from the viral precursors. Spumaretroviruses produce separate precursors for Ga...
- Chloroplast DnaJ-like proteins 3 and 4 (CDJ3/4) from Chlamydomonas reinhardtii contain redox-active Fe-S clusters and interact with stromal HSP70B
[作者：Dorn, KV; Willmund, F; Schwarz, C; Henselmann, C; Pohl, T; Hess, B; Veyel, D; Usadel, B; Friedrich, T; Nickelsen, J; Schroda, M,期刊：Biochemical Journal, 页码：205-215 , 文章类型： Article，,卷期：2010年427-Part 2]
- In the present study we report on the identification and characterization of three novel chloroplast-targeted DnaJ-like proteins CDJ3-5, which in addition to their J-domains contain bacterial-type ferredoxin domains. In ...
- Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: structural and biochemical insights
[作者：Merabet, A; Houlleberghs, H; Maclagan, K; Akanho, E; Bui, TTT; Pagano, B; Drake, AF; Fraternali, F; Nikolova, PV,期刊：Biochemical Journal, 页码：225-236 , 文章类型： Article，,卷期：2010年427-Part 2]
- To assess the potential of mutations from the L 1 loop of the tumour suppressor p53 as second-site suppressors, the effect of H115N and S116M on the p53 'hot spot' mutations has been investigated using the double-mutant ...
- Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins
[作者：Yasmin, L; Veesenmeyer, JL; Diaz, MH; Francis, MS; Ottmann, C; Palmer, RH; Hauser, AR; Hallberg, B,期刊：Biochemical Journal, 页码：217-224 , 文章类型： Article，,卷期：2010年427-Part 2]
- 14-3-3 proteins belong to a family of conserved molecules expressed in all eukaryotic cells that play an important role in a multitude of signalling pathways. 14-3-3 proteins bind either to phosphoserine/phosphothreonine...
- Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPAR gamma
[作者：Aguilo, F; Camarero, N; Relat, J; Marrero, PF; Haro, D,期刊：Biochemical Journal, 页码：255-264 , 文章类型： Article，,卷期：2010年427-Part 2]
- In the cytosol of lipogenic tissue, ketone bodies are activated by AACS (acetoacetyl-CoA synthetase) and incorporated into cholesterol and fatty acids. AACS gene expression is particularly abundant in white adipose tissu...
- Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation
[作者：Nakagawa, K; Sugahara, M; Yamasaki, T; Kajiho, H; Takahashi, S; Hirayama, J; Minami, Y; Ohta, Y; Watanabe, T; Hata, Y; Katada, T; Nishina, H,期刊：Biochemical Journal, 页码：237-245 , 文章类型： Article，,卷期：2010年427-Part 2]
- SAPK/JNK (stress-activated protein kinase/c-Jun N-terminal kinase) belongs to the MAPK (mitogen-activated protein kinase) family and is important in many biological contexts. JNK activation is regulated by phosphorylatio...
- Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca2+ in Saccharomyces cerevisiae
[作者：Takatsume, Y; Ohdate, T; Maeta, K; Nomura, W; Izawa, S; Inoue, Y,期刊：Biochemical Journal, 页码：275-287 , 文章类型： Article，,卷期：2010年427-Part 2]
- Although methylglyoxal is derived from glycolysis, it has adverse effects on cellular function. Hence, the intrinsic role of methylglyoxal in vivo remains to be determined. Glyoxalase 1 is a pivotal enzyme in the metabol...
- Dihydroceramide desaturase activity is modulated by oxidative stress
[作者：Idkowiak-Baldys, J; Apraiz, A; Li, L; Rahmaniyan, M; Clarke, CJ; Kraveka, JM; Asumendi, A; Hannun, YA,期刊：Biochemical Journal, 页码：265-274 , 文章类型： Article，,卷期：2010年427-Part 2]
- Oxidative stress has been implicated previously in the regulation of ceramide metabolism. In the present study, its effects on dihydroceramide desaturase were investigated. To stimulate oxidative stress, HEK (human embyr...
- Characterization of the transition-metal-binding properties of hepcidin
[作者：Tselepis, C; Ford, SJ; McKie, AT; Vogel, W; Zoller, H; Simpson, RJ; Castro, JD; Iqbal, TH; Ward, DG,期刊：Biochemical Journal, 页码：289-296 , 文章类型： Article，,卷期：2010年427-Part 2]
- Accumulating evidence suggests that hepcidin, a 25-residue peptide hormone, is the master regulator of iron metabolism. Further evidence suggests that the five N-terminal amino acids are crucial for mediating its biologi...
- Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons
[作者：Hoshino, M; Tsujimoto, T; Yamazoe, S; Uesugi, M; Terada, S,期刊：Biochemical Journal, 页码：297-304 , 文章类型： Article，,卷期：2010年427-Part 2]
- Attachment to the substrate is essential for both survival and differentiation of various kinds of cells, such as neurons and epithelial cells. We recently found a small synthetic molecule, adhesamine, which boosts adhes...
- A novel EP-involved pathway for iron release from soya bean seed ferritin
[作者：Fu, XP; Deng, JJ; Yang, HX; Masuda, T; Goto, F; Yoshihara, T; Zhao, GH,期刊：Biochemical Journal, 页码：313-321 , 文章类型： Article，,卷期：2010年427-Part 2]
- Iron in phytoferritin from legume seeds is required for seedling germination and early growth. However, the mechanism by which phytoferritin regulates its iron complement to these physiological processes remains unknown....
- Insertion of an NPVY sequence into the cytosolic domain of the erythropoietin receptor selectively affects erythropoietin-mediated signalling and function
[作者：Liron, T; Nahari, T; Souroujon, MC; Neumann, D,期刊：Biochemical Journal, 页码：305-312 , 文章类型： Article，,卷期：2010年427-Part 2]
- EPO (erythropoietin), the major hormone regulating erythropoiesis, functions via activation of its cell-surface receptor (EPO-R) present on erythroid progenitor cells. One of the most striking properties of EPO-R is its ...
- Novel insights into mannitol metabolism in the fungal plant pathogen Botrytis cinerea
[作者：Dulermo, T; Rascle, C; Billon-Grand, G; Gout, E; Bligny, R; Cotton, P,期刊：Biochemical Journal, 页码：323-332 , 文章类型： Article，,卷期：2010年427-Part 2]
- In order to redefine the mannitol pathway in the necrotrophic plant pathogen Botrytis cinerea, we used a targeted deletion strategy of genes encoding two proteins of mannitol metabolism, BcMTDH (B. cinerea mannitol dehyd...
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