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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Role of conservative mutations in protein multi-property adaptation [作者：Rodriguez-Larrea, D; Perez-Jimenez, R; Sanchez-Romero, I; Delgado-Delgado, A; Fernandez, JM; Sanchez-Ruiz, JM,期刊：Biochemical Journal, 页码：243-249 , 文章类型： Article，,卷期：2010年429-Part 2] Protein physicochemical properties must undergo complex changes during evolution, as a response to modifications in the organism environment, the result of the proteins taking up new roles or because of the need to cope ... Conformational flexibility and allosteric regulation of cathepsin K [作者：Novinec, M; Kovacic, L; Lenarcic, B; Baici, A,期刊：Biochemical Journal, 页码：379-389 , 文章类型： Article，,卷期：2010年429-Part 2] The human cysteine peptidase cathepsin K is a key enzyme in bone homoeostasis and other physiological functions. In the present study we investigate the mechanism of cathepsin K action at physiological plasma pH and its ... An extracellular transglutaminase is required for apple pollen tube growth [作者：Di Sandro, A; Del Duca, S; Verderio, E; Hargreaves, AJ; Scarpellini, A; Cai, G; Cresti, M; Faleri, C; Iorio, RA; Hirose, S; Furutani, Y; Coutts, IGC; Griffin, M; Bonner, PLR; Serafini-Fracassini, D,期刊：Biochemical Journal, 页码：261-271 , 文章类型： Article，,卷期：2010年429-Part 2] An extracellular form of the calcium-dependent protein-cross-linking enzyme TGase (transglutaminase) was demonstrated to be involved in the apical growth of Mains domestica pollen tube. Apple pollen TGase and its substra... Pleiotropic mechanisms facilitated by resveratrol and its metabolites [作者：Calamini, B; Ratia, K; Malkowski, MG; Cuendet, M; Pezzuto, JM; Santarsiero, BD; Mesecar, AD,期刊：Biochemical Journal, 页码：273-282 , 文章类型： Article，,卷期：2010年429-Part 2] Resveratrol has demonstrated cancer chemopreventive activity in animal models and some clinical trials are underway. In addition, resveratrol was shown to promote cell survival, increase lifespan and mimic caloric restri... The dissociated form of kappa-casein is the precursor to its amyloid fibril formation [作者：Ecroyd, H; Thorn, DC; Liu, YQ; Carver, JA,期刊：Biochemical Journal, 页码：251-260 , 文章类型： Article，,卷期：2010年429-Part 2] Bovine milk kappa-casein forms a self-associating oligomeric micelle-like species, in equilibrium with dissociated forms. In its native form, intra- and inter-molecular disulfide bonds lead to the formation of multimeric... Biological roles of translin and translin-associated factor-X: RNA metabolism comes to the fore [作者：Jaendling, A; McFarlane, RJ,期刊：Biochemical Journal, 页码：225-234 , 文章类型： Review，,卷期：2010年429-Part 2] Translin, and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins, which have been implicated in a broad spectrum of biological activities, including cell growth re... Zebrafish: gaining popularity in lipid research [作者：Holtta-Vuori, M; Salo, VTV; Nyberg, L; Brackmann, C; Enejder, A; Panula, P; Ikonen, E,期刊：Biochemical Journal, 页码：235-242 , 文章类型： Review，,卷期：2010年429-Part 2] Zebrafish are an increasingly popular vertebrate model organism in which to study biological phenomena. It has been widely used, especially ill developmental biology and neurobiology, and many aspects of its development ... The identification of the SNARE complex required for the fusion of VLDL-transport vesicle with hepatic cis-Golgi [作者：Siddiqi, S; Mani, AM; Siddiqi, SA,期刊：Biochemical Journal, 页码：391-401 , 文章类型： Article，,卷期：2010年429-Part 2] VLDLs (very-low-density lipoproteins) are synthesized in the liver and play an important role in the pathogenesis of atherosclerosis. Following their biogenesis in hepatic ER (endoplasmic reticulum), nascent VLDLs are ex... Kinase-related protein/telokin inhibits Ca2+-independent contraction in Triton-skinned guinea pig taenia coil [作者：Shcherbakova, OV; Serebryanaya, DV; Postnikov, AB; Schroeter, MM; Zittrich, S; Noegel, AA; Shirinsky, VP; Vorotnikov, AV; Pfitzer, G,期刊：Biochemical Journal, 页码：291-302 , 文章类型： Article，,卷期：2010年429-Part 2] KRP (kinase-related protein), also known as telokin, has been proposed to inhibit smooth muscle contractility by inhibiting the phosphorylation of the rMLC (regulatory myosin light chain) by the Ca2+-activated MLCK (myos... Expression of oestrogen receptor beta isoforms is regulated by transcriptional and post-transcriptional mechanisms [作者：Smith, L; Coleman, LJ; Cummings, M; Satheesha, S; Shaw, SO; Speirs, V; Hughes, TA,期刊：Biochemical Journal, 页码：283-290 , 文章类型： Article，,卷期：2010年429-Part 2] Although ERs (oestrogen receptors) mediate breast tumour behaviour, the precise role of ER beta remains unclear. This is mainly because analyses have been complicated by the presence in breast tissue of three ER beta pro... Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme [作者：Foo, JL; Jackson, CJ; Carr, PD; Kim, HK; Schenk, G; Gahan, LR; Ollis, DL,期刊：Biochemical Journal, 页码：313-321 , 文章类型： Article，,卷期：2010年429-Part 2] The metal ion co-ordination sites of many metalloproteins have been characterized by a variety of spectroscopic techniques and small-molecule model systems, revealing many important insights into the structural determina... ATP storage and uptake by isolated pancreatic zymogen granules [作者：Haanes, KA; Novak, I,期刊：Biochemical Journal, 页码：303-311 , 文章类型： Article，,卷期：2010年429-Part 2] ATP is released from pancreatic acini in response to cholinergic and hormonal stimulation. The same stimuli cause exocytosis of ZG (zymogen granules) and release of digestive enzymes. The aim of the present study was to ... Attenuation of the hypoxia-induced protein kinase C delta interaction with the 'd' subunit of F1Fo-ATP synthase in neonatal cardiac myocytes: implications for energy preservation and survival [作者：Nguyen, TT; Ogbi, M; Yu, QL; Johnson, JA,期刊：Biochemical Journal, 页码：335-345 , 文章类型： Article，,卷期：2010年429-Part 2] The F1Fo-ATP synthase provides most of the heart's energy, yet events that alter its function during injury are poorly understood. Recently, we described a potent inhibitory effect on F1Fo-ATP synthase function mediated ... Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia [作者：Beall, C; Piipari, K; Al-Qassab, H; Smith, MA; Parker, N; Carling, D; Viollet, B; Withers, DJ; Ashford, MLJ,期刊：Biochemical Journal, 页码：323-333 , 文章类型： Article，,卷期：2010年429-Part 2] AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic beta-cell function remains unclear. In the present stusy, we therefore investigat... The glycosylation of human synovial lubricin: implications for its role in inflammation [作者：Estrella, RP; Whitelock, JM; Packer, NH; Karlsson, NG,期刊：Biochemical Journal, 页码：359-367 , 文章类型： Article，,卷期：2010年429-Part 2] Acidic proteins were isolated from synovial fluid from two osteoarthritic and two rheumatoid arthritic patients and identified by MS. It was found that the most abundant protein in all of the samples was the mucin-like p... Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells [作者：Ishimoto, K; Tachibana, K; Hanano, I; Yamasaki, D; Nakamura, H; Kawai, M; Urano, Y; Tanaka, T; Hamakubo, T; Sakai, J; Kodama, T; Doi, T,期刊：Biochemical Journal, 页码：347-357 , 文章类型： Article，,卷期：2010年429-Part 2] FDPS (farnesyl diphosphate synthase) catalyses the formation of farnesyl diphosphate, a key intermediate in the synthesis of cholesterol and isoprenylated cellular metabolites. FDPS is also the molecular target of nitrog...