- Targeting 14-3-3zeta in cancer therapy
[作者：Yang, X; Cao, W; Zhang, L; Zhang, W; Zhang, X; Lin, H,期刊：Cancer gene therapy, 页码：153-159 , 文章类型： Review，,卷期：2012年19-3]
- An effective therapeutic target is imperative for cancer treatment, including gene therapy. 14-3-3zeta, a member of the 14-3-3 protein family, acts as a suppressor of apoptosis and has a central role in tumor genesis and...
- Oncolytic Herpes simplex virus expressing yeast cytosine deaminase: relationship between viral replication, transgene expression, prodrug bioactivation
[作者：Yamada, S; Kuroda, T; Fuchs, BC; He, X; Supko, JG; Schmitt, A; McGinn, CM; Lanuti, M; Tanabe, KK,期刊：Cancer gene therapy, 页码：160-170 , 文章类型： Article，,卷期：2012年19-3]
- Yeast cytosine deaminase (yCD) is a well-characterized prodrug/enzyme system that converts 5-fluorocytosine (5-FC) to 5-fluorouracil (5-FU), and has been combined with oncolytic viruses. However, in vivo studies of the i...
- Sonoporation-mediated anti-angiogenic gene transfer into muscle effectively regresses distant orthotopic tumors
[作者：Liao, ZK; Tsai, KC; Wang, HT; Tseng, SH; Deng, WP; Chen, WS; Hwang, LH,期刊：Cancer gene therapy, 页码：171-180 , 文章类型： Article，,卷期：2012年19-3]
- Ultrasound (US) is an effective tool for local delivery of genes into target tumors or organs. In combination with microbubbles, US can temporarily change the permeability of cell membranes by cavitation and facilitate e...
- Chemovirotherapy for head and neck squamous cell carcinoma with EGFR-targeted and CD/UPRT-armed oncolytic measles virus
[作者：Zaoui, K; Bossow, S; Grossardt, C; Leber, MF; Springfeld, C; Plinkert, PK; von Kalle, C; Ungerechts, G,期刊：Cancer gene therapy, 页码：181-191 , 文章类型： Article，,卷期：2012年19-3]
- First-line treatment of recurrent and/or refractory head and neck squamous cell carcinoma (HNSCC) is based on platinum, 5-fluorouracil (5-FU) and the monoclonal anti EGFR antibody cetuximab. However, in most cases this c...
- Oncolytic poxvirus armed with Fas ligand leads to induction of cellular Fas receptor and selective viral replication in FasR-negative cancer
[作者：Sathaiah, M; Thirunavukkarasu, P; O'Malley, ME; Kavanagh, MA; Ravindranathan, R; Austin, F; Guo, ZS; Bartlett, DL,期刊：Cancer gene therapy, 页码：192-201 , 文章类型： Article，,卷期：2012年19-3]
- Tumor necrosis factor superfamily members, including Fas ligand and TRAIL, have been studied extensively for cancer therapy, including as components of gene therapy. We examined the use of FasL expression to achieve tumo...
- Polyinosinic acid decreases sequestration and improves systemic therapy of measles virus
[作者：Liu, YP; Tong, C; Dispenzieri, A; Federspiel, MJ; Russell, SJ; Peng, KW,期刊：Cancer gene therapy, 页码：202-211 , 文章类型： Article，,卷期：2012年19-3]
- Off-target binding or vector sequestration can significantly limit the efficiency of systemic virotherapy. We report here that systemically administered oncolytic measles virus (MV) was rapidly sequestered by the mononuc...
- Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma
[作者：Rainusso, N; Brawley, VS; Ghazi, A; Hicks, MJ; Gottschalk, S; Rosen, JM; Ahmed, N,期刊：Cancer gene therapy, 页码：212-217 , 文章类型： Article，,卷期：2012年19-3]
- Despite radical surgery and multi-agent chemotherapy, less than one third of patients with recurrent or metastatic osteosarcoma (OS) survive. The limited efficacy of current therapeutic approaches to target tumor-initiat...
- Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed
[作者：Li, Q; Kawamura, K; Yamanaka, M; Okamoto, S; Yang, S; Yamauchi, S; Fukamachi, T; Kobayashi, H; Tada, Y; Takiguchi, Y; Tatsumi, K; Shimada, H; Hiroshima, K; Tagawa, M,期刊：Cancer gene therapy, 页码：218-228 , 文章类型： Article，,卷期：2012年19-3]
- The majority of malignant mesothelioma possesses the wild-type p53 gene with a homologous deletion of the INK4A/ARF locus containing the p14(ARF) and the p16(INK4A) genes. We examined whether forced expression of p53 inh...
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