- Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
[作者:Iwawaki, T; Akai, R; Yamanaka, S; Kohno, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16657-16662 , 文章类型: Article,,卷期:2009年106-39]
- Inositol requiring enzyme-1 (IRE1), a protein located on the endoplasmic reticulum (ER) membrane, is highly conserved from yeast to humans. This protein is activated during ER stress and induces cellular adaptive respons...
- Dual role of K-ATP channel C-terminal motif in membrane targeting and metabolic regulation
[作者:Kline, CF; Kurata, HT; Hund, TJ; Cunha, SR; Koval, OM; Wright, PJ; Christensen, M; Anderson, ME; Nichols, CG; Mohler, PJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16669-16674 , 文章类型: Article,,卷期:2009年106-39]
- The coordinated sorting of ion channels to specific plasma membrane domains is necessary for excitable cell physiology. K-ATP channels, assembled from pore-forming (Kir6.x) and regulatory sulfonylurea receptor subunits, ...
- IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas
[作者:Moore, LM; Holmes, KM; Smith, SM; Wu, Y; Tchougounova, E; Uhrbom, L; Sawaya, R; Bruner, JM; Fuller, GN; Zhang, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16675-16679 , 文章类型: Article,,卷期:2009年106-39]
- The levels of insulin-like growth factor-binding protein 2 (IGFBP2) are elevated during progression of many human cancers. By using a glial-specific transgenic mouse system (RCAS/Ntv-a), we reported previously that IGFBP...
- Central role of TRAF-interacting protein in a new model of brain sexual differentiation
[作者:Krishnan, S; Intlekofer, KA; Aggison, LK; Petersen, SL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16692-16697 , 文章类型: Article,,卷期:2009年106-39]
- Sexually dimorphic brain nuclei underlie gender-specific neural functions and susceptibility to disease, but the developmental basis of dimorphisms is poorly understood. In these studies, we focused on the anteroventral ...
- Modeling early retinal development with human embryonic and induced pluripotent stem cells
[作者:Meyer, JS; Shearer, RL; Capowski, EE; Wright, LS; Wallace, KA; McMillan, EL; Zhang, SC; Gamm, DM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16698-16703 , 文章类型: Article,,卷期:2009年106-39]
- Human pluripotent stem cells have the potential to provide comprehensive model systems for the earliest stages of human ontogenesis. To serve in this capacity, these cells must undergo a targeted, stepwise differentiatio...
- The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development
[作者:Grossmann, KS; Wende, H; Paul, FE; Cheret, C; Garratt, AN; Zurborg, S; Feinberg, K; Besser, D; Schulz, H; Peles, E; Selbach, M; Birchmeier, W; Birchmeier, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16704-16709 , 文章类型: Article,,卷期:2009年106-39]
The nonreceptor tyrosine phosphatase Shp2 (PTPN11) has been implicated in tyrosine kinase, cytokine, and integrin receptor signaling. We show here that conditional mutation of Shp2 in neural crest cells and in myelina...
- Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality
[作者:Klinger, S; Turgeon, B; Levesque, K; Wood, GA; Aagaard-Tillery, KM; Meloche, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16710-16715 , 文章类型: Article,,卷期:2009年106-39]
- Extracellular signal-regulated kinase 3 (Erk3) is an atypical member of the mitogen-activated protein (MAP) kinase family. No function has yet been ascribed to this MAP kinase. Here we show that targeted disruption of th...
- Fossil and molecular evidence constrain scenarios for the early evolutionary and biogeographic history of hystricognathous rodents
[作者:Sallam, HM; Seiffert, ER; Steiper, ME; Simons, EL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16722-16727 , 文章类型: Article,,卷期:2009年106-39]
- The early evolutionary and paleobiogeographic history of the diverse rodent clade Hystricognathi, which contains Hystricidae (Old World porcupines), Caviomorpha (the endemic South American rodents), and African Phiomorph...
- Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans
[作者:Xu, B; Woodroffe, A; Rodriguez-Murillo, L; Roos, JL; van Rensburg, EJ; Abecasis, GR; Gogos, JA; Karayiorgou, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16746-16751 , 文章类型: Article,,卷期:2009年106-39]
- To elucidate the genetic architecture of familial schizophrenia we combine linkage analysis with studies of fine-level chromosomal variation in families recruited from the Afrikaner population in South Africa. We demonst...
|