- Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition
[作者:Arancibia-Carcamo, IL; Yuen, EY; Muir, J; Lumb, MJ; Michels, G; Saliba, RS; Smart, TG; Yan, Z; Kittler, JT; Moss, SJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17552-17557 , 文章类型: Article,,卷期:2009年106-41]
- The strength of synaptic inhibition depends partly on the number of GABA(A) receptors (GABA(A)Rs) found at synaptic sites. The trafficking of GABA(A)Rs within the endocytic pathway is a key determinant of surface GABA(A)...
- Learning sculpts the spontaneous activity of the resting human brain
[作者:Lewisa, CM; Baldassarre, A; Committeri, G; Romani, GL; Corbetta, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17558-17563 , 文章类型: Article,,卷期:2009年106-41]
- The brain is not a passive sensory-motor analyzer driven by environmental stimuli, but actively maintains ongoing representations that may be involved in the coding of expected sensory stimuli, prospective motor response...
- aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues
[作者:Mao, JQ; Yang, T; Gu, ZW; Heird, WC; Finegold, MJ; Lee, B; Wakil, SJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17576-17581 , 文章类型: Article,,卷期:2009年106-41]
- Adipose tissue is one of the major sites for fatty acid synthesis and lipid storage. We generated adipose (fat)-specific ACC1 knockout (FACC1KO) mice using the aP2-Cre/loxP system. FACC1KO mice showed prenatal growth ret...
- Glucocorticoid regulation of the circadian clock modulates glucose homeostasis
[作者:So, AYL; Bernal, TU; Pillsbury, ML; Yamamoto, KR; Feldman, BJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17582-17587 , 文章类型: Article,,卷期:2009年106-41]
- Circadian clock genes are regulated by glucocorticoids; however, whether this regulation is a direct or secondary effect and the physiological consequences of this regulation were unknown. Here, we identified glucocortic...
- Cargo binding induces dimerization of myosin VI
[作者:Phichith, D; Travaglia, M; Yang, ZH; Liu, XY; Zong, AB; Safer, D; Sweeney, HL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17320-17324 , 文章类型: Article,,卷期:2009年106-41]
- Although myosin VI has properties that would allow it to function optimally as a dimer, full-length myosin VI exists as a monomer in isolation. Based on the ability of myosin VI monomers to dimerize when held in close pr...
- Crystal structure of native RPE65, the retinoid isomerase of the visual cycle
[作者:Kiser, PD; Golczak, M; Lodowski, DT; Chance, MR; Palczewski, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17325-17330 , 文章类型: Article,,卷期:2009年106-41]
- Vertebrate vision is maintained by the retinoid (visual) cycle, a complex enzymatic pathway that operates in the retina to regenerate the visual chromophore, 11-cis-retinal. A key enzyme in this pathway is the microsomal...
- How oxygen attacks [FeFe] hydrogenases from photosynthetic organisms
[作者:Stripp, ST; Goldet, G; Brandmayr, C; Sanganas, O; Vincent, KA; Haumann, M; Armstrong, FA; Happe, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17331-17336 , 文章类型: Article,,卷期:2009年106-41]
- Green algae such as Chlamydomonas reinhardtii synthesize an [FeFe] hydrogenase that is highly active in hydrogen evolution. However, the extreme sensitivity of [FeFe] hydrogenases to oxygen presents a major challenge for...
- Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis
[作者:Umezawa, T; Sugiyama, N; Mizoguchi, M; Hayashi, S; Myouga, F; Yamaguchi-Shinozaki, K; Ishihama, Y; Hirayama, T; Shinozaki, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17588-17593 , 文章类型: Article,,卷期:2009年106-41]
- Abscisic acid (ABA) signaling is important for stress responses and developmental processes in plants. A subgroup of protein phosphatase 2C (group A PP2C) or SNF1-related protein kinase 2 (subclass III SnRK2) have been k...
- Differing requirements for actin and myosin by plant viruses for sustained intercellular movement
[作者:Harries, PA; Park, JW; Sasaki, N; Ballard, KD; Maule, AJ; Nelson, RS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17594-17599 , 文章类型: Article,,卷期:2009年106-41]
- The actin cytoskeleton has been implicated in the intra- and intercellular movement of a growing number of plant and animal viruses. However, the range of viruses influenced by actin for movement and the mechanism of thi...
- Long-term risk preference and suboptimal decision making following adolescent alcohol use
[作者:Nasrallah, NA; Yang, TWH; Bernstein, IL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17600-17604 , 文章类型: Article,,卷期:2009年106-41]
- Individuals who abused alcohol at an early age show decision-making impairments. However, the question of whether maladaptive choice constitutes a predisposing factor to, or a consequence resulting from, alcohol exposure...
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