- Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils
[作者:Rosen, H; Klebanoff, SJ; Wang, Y; Brot, N; Heinecke, JW; Fu, XY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18686-18691 , 文章类型: Article,,卷期:2009年106-44]
- Reactive oxygen intermediates generated by neutrophils kill bacteria and are implicated in inflammatory tissue injury, but precise molecular targets are undefined. We demonstrate that neutrophils use myeloperoxidase (MPO...
- Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands
[作者:Gendzekhadze, K; Norman, PJ; Abi-Rached, L; Graef, T; Moesta, AK; Layrisse, Z; Parham, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18692-18697 , 文章类型: Article,,卷期:2009年106-44]
- Natural killer (NK) cells contribute to immunity and reproduction. Guiding these functions, and NK cell education, are killer cell Ig-like receptors (KIR), NK cell receptors that recognize HLA class I. In most human popu...
- Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas
[作者:Nepal, RM; Tong, L; Kolaj, B; Edelmann, W; Martin, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18698-18703 , 文章类型: Article,,卷期:2009年106-44]
- C-Myc is one of the most common targets of genetic alterations in human cancers. Although overexpression of c-Myc in the B cell compartment predisposes to lymphomas, secondary mutations are required for disease manifesta...
- Recent changes in a remote Arctic lake are unique within the past 200,000 years
[作者:Axford, Y; Briner, JP; Cooke, CA; Francis, DR; Michelutti, N; Miller, GH; Smol, JP; Thomas, EK; Wilson, CR; Wolfe, AP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18443-18446 , 文章类型: Article,,卷期:2009年106-44]
- The Arctic is currently undergoing dramatic environmental transformations, but it remains largely unknown how these changes compare with long-term natural variability. Here we present a lake sediment sequence from the Ca...
- Household actions can provide a behavioral wedge to rapidly reduce US carbon emissions
[作者:Dietz, T; Gardner, GT; Gilligan, J; Stern, PC; Vandenbergh, MP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18452-18456 , 文章类型: Article,,卷期:2009年106-44]
- Most climate change policy attention has been addressed to long-term options, such as inducing new, low-carbon energy technologies and creating cap-and-trade regimes for emissions. We use a behavioral approach to examine...
- Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors
[作者:Longbottom, R; Fruttiger, M; Douglas, RH; Martinez-Barbera, JP; Greenwood, J; Moss, SE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18728-18733 , 文章类型: Article,,卷期:2009年106-44]
- The retinal pigment epithelium (RPE) plays a critical role in the maintenance of the outer retina. RPE cell death or dysfunction drives the pathophysiology of many retinal diseases, but the physiological response of the ...
- Myocardin is required for cardiomyocyte survival and maintenance of heart function
[作者:Huang, JH; Lu, MM; Cheng, L; Yuan, LJ; Zhu, XQ; Stout, AL; Chen, M; Li, J; Parmacek, MS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18734-18739 , 文章类型: Article,,卷期:2009年106-44]
- Despite intense investigation over the past century, the molecular mechanisms that regulate maintenance and adaptation of the heart during postnatal development are poorly understood. Myocardin is a remarkably potent tra...
- Paper-supported 3D cell culture for tissue-based bioassays
[作者:Derda, R; Laromaine, A; Mammoto, A; Tang, SKY; Mammoto, T; Ingber, DE; Whitesides, GM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18457-18462 , 文章类型: Article,,卷期:2009年106-44]
- Fundamental investigations of human biology, and the development of therapeutics, commonly rely on 2D cell-culture systems that do not accurately recapitulate the structure, function, or physiology of living tissues. Sys...
- Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase
[作者:Li, SY; Chaulagain, MR; Knauff, AR; Podust, LM; Montgomery, J; Sherman, DH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18463-18468 , 文章类型: Article,,卷期:2009年106-44]
- Regio- and stereoselective oxidation of an unactivated C-H bond remains a central challenge in organic chemistry. Considerable effort has been devoted to identifying transition metal complexes, biological catalysts, or s...
- Stepwise formation of P-cluster in nitrogenase MoFe protein
[作者:Lee, CC; Blank, MA; Fay, AW; Yoshizawa, JM; Hu, YL; Hodgson, KO; Hedman, B; Ribbe, MW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18474-18478 , 文章类型: Article,,卷期:2009年106-44]
- The P-cluster of nitrogenase is one of the most complex biological metallocenters known to date. Despite the recent advances in the chemical synthesis of P-cluster topologs, the biosynthetic mechanism of P-cluster has no...
- Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck
[作者:Persson, M; Andren, Y; Mark, J; Horlings, HM; Persson, F; Stenman, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18740-18744 , 文章类型: Article,,卷期:2009年106-44]
- The transcription factor gene MYB was identified recently as an oncogene that is rearranged/duplicated in some human leukemias. Here we describe a new mechanism of activation of MYB in human cancer involving gene fusion....
- Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
[作者:Sears, DD; Hsiao, G; Hsiao, A; Yu, JG; Courtney, CH; Ofrecio, JM; Chapman, J; Subramaniam, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18745-18750 , 文章类型: Article,,卷期:2009年106-44]
- Cellular and tissue defects associated with insulin resistance are coincident with transcriptional abnormalities and are improved after insulin sensitization with thiazolidinedione (TZD) PPAR gamma ligands. We characteri...
- Bacterial origin recognition complexes direct assembly of higher-order DnaA oligomeric structures
[作者:Miller, DT; Grimwade, JE; Betteridge, T; Rozgaja, T; Torgue, JJC; Leonard, AC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18479-18484 , 文章类型: Article,,卷期:2009年106-44]
- Eukaryotic initiator proteins form origin recognition complexes (ORCs) that bind to replication origins during most of the cell cycle and direct assembly of prereplication complexes (pre-RCs) before the onset of S phase....
- Refolding of the integral membrane protein light-harvesting complex II monitored by pulse EPR
[作者:Dockter, C; Volkov, A; Bauer, C; Polyhach, Y; Joly-Lopez, Z; Jeschke, G; Paulsen, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18485-18490 , 文章类型: Article,,卷期:2009年106-44]
- The major light-harvesting chlorophyll a/b complex (LHCII) of the photosynthetic apparatus in plants self-organizes in vitro. The recombinant apoprotein, denatured in dodecyl sulfate, spontaneously folds when it is mixed...
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