- Single molecule detection of direct, homologous, DNA/DNA pairing
[作者:Danilowicz, C; Lee, CH; Kim, K; Hatch, K; Coljee, VW; Kleckner, N; Prentiss, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19824-19829 , 文章类型: Article,,卷期:2009年106-47]
- Using a parallel single molecule magnetic tweezers assay we demonstrate homologous pairing of two double-stranded (ds) DNA molecules in the absence of proteins, divalent metal ions, crowding agents, or free DNA ends. Pai...
- Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
[作者:Hudson, BP; Quispe, J; Lara-Gonzalez, S; Kim, Y; Berman, HM; Arnold, E; Ebright, RH; Lawson, CL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19830-19835 , 文章类型: Article,,卷期:2009年106-47]
- We present the experimentally determined 3D structure of an intact activator-dependent transcription initiation complex comprising the Escherichia coli catabolite activator protein (CAP), RNA polymerase holoenzyme (RNAP)...
- Canonical Wnt signaling negatively regulates platelet function
[作者:Steele, BM; Harper, MT; Macaulay, IC; Morrell, CN; Perez-Tamayo, A; Foy, M; Habas, R; Poole, AW; Fitzgerald, DJ; Maguire, PB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19836-19841 , 文章类型: Article,,卷期:2009年106-47]
- Wnts regulate important intracellular signaling events, and dysregulation of the Wnt pathway has been linked to human disease. Here, we uncover numerous Wnt canonical effectors in human platelets where Wnts, their recept...
- PHS1 regulates meiotic recombination and homologous chromosome pairing by controlling the transport of RAD50 to the nucleus
[作者:Ronceret, A; Doutriaux, MP; Golubovskaya, IN; Pawlowski, WP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20121-20126 , 文章类型: Article,,卷期:2009年106-47]
- Recombination and pairing of homologous chromosomes are critical for bivalent formation in meiotic prophase. In many organisms, including yeast, mammals, and plants, pairing and recombination are intimately interconnecte...
- Localization of mRNAs coding for peroxisomal proteins in the yeast, Saccharomyces cerevisiae
[作者:Zipor, G; Haim-Vilmovsky, L; Gelin-Licht, R; Gadir, N; Brocard, C; Gerst, JE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19848-19853 , 文章类型: Article,,卷期:2009年106-47]
- Targeted mRNA trafficking and local translation may play a significant role in controlling protein localization. Here we examined for the first time the localization of all (approximate to 50) mRNAs encoding peroxisomal ...
- Identification of CCR4 and other essential thyroid hormone receptor co-activators by modified yeast synthetic genetic array analysis
[作者:Govindan, M; Meng, XW; Denis, CL; Webb, P; Baxter, JD; Walfish, PG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19854-19859 , 文章类型: Article,,卷期:2009年106-47]
- Identification of thyroid hormone receptor (TR) co-regulators has enhanced our understanding of thyroid hormone (TH) action. However, it is likely that many other co-regulators remained unidentified, and unbiased methods...
- MRPS18-2 protein immortalizes primary rat embryonic fibroblasts and endows them with stem cell-like properties
[作者:Kashuba, E; Yenamandra, SP; Darekar, SD; Yurchenko, M; Kashuba, V; Klein, G; Szekely, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19866-19871 , 文章类型: Article,,卷期:2009年106-47]
- We report that the overexpression of mitochondrial ribosomal protein MRPS18-2 (S18-2) can immortalize primary rat embryonic fibroblasts (REFs). The immortalized cells (18IM) lose contact inhibition, form foci, and are ca...
- DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis
[作者:Xie, DX; Gore, C; Zhou, J; Pong, RC; Zhang, HF; Yu, LY; Vessella, RL; Min, W; Hsieh, JT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19878-19883 , 文章类型: Article,,卷期:2009年106-47]
- In metastatic prostate cancer (PCa) cells, imbalance between cell survival and death signals such as constitutive activation of phosphatidylinositol 3-kinase (PI3K)-Akt and inactivation of apoptosis-stimulated kinase (AS...
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