- Synergistic effect of HIF-1 alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
[作者:Rey, S; Lee, K; Wang, CJ; Gupta, K; Chen, SP; McMillan, A; Bhise, N; Levchenko, A; Semenza, GL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20399-20404 , 文章类型: Article,,卷期:2009年106-48]
- Ischemia induces the production of angiogenic cytokines and the homing of bone-marrow-derived angiogenic cells (BMDACs), but these adaptive responses become impaired with aging because of reduced expression of hypoxia-in...
- Increased muscle PGC-1 alpha expression protects from sarcopenia and metabolic disease during aging
[作者:Wenz, T; Rossi, SG; Rotundo, RL; Spiegelman, BM; Moraes, CT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20405-20410 , 文章类型: Article,,卷期:2009年106-48]
- Aging is a major risk factor for metabolic disease and loss of skeletal muscle mass and strength, a condition known as sarcopenia. Both conditions present a major health burden to the elderly population. Here, we analyze...
- Design and construction of diverse mammalian prion strains
[作者:Colby, DW; Giles, K; Legname, G; Wille, H; Baskakov, IV; DeArmond, SJ; Prusiner, SB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20417-20422 , 文章类型: Article,,卷期:2009年106-48]
- Prions are infectious proteins that encipher biological information within their conformations; variations in these conformations dictate different prion strains. Toward elucidating the molecular language of prion protei...
- Two- and three-dimensional folding of thin film single-crystalline silicon for photovoltaic power applications
[作者:Guo, XY; Li, H; Ahn, BY; Duoss, EB; Hsia, KJ; Lewis, JA; Nuzzo, RG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20149-20154 , 文章类型: Article,,卷期:2009年106-48]
- Fabrication of 3D electronic structures in the micrometer-to-millimeter range is extremely challenging due to the inherently 2D nature of most conventional wafer-based fabrication methods. Self-assembly, and the related ...
- Wet phases in the Sahara/Sahel region and human migration patterns in North Africa
[作者:Castaneda, IS; Mulitza, S; Schefuss, E; dos Santos, RAL; Damste, JSS; Schouten, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20159-20163 , 文章类型: Article,,卷期:2009年106-48]
- The carbon isotopic composition of individual plant leaf waxes (a proxy for C-3 vs. C-4 vegetation) in a marine sediment core collected from beneath the plume of Sahara-derived dust in northwest Africa reveals three peri...
- Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling
[作者:Pflegerl, P; Vesely, P; Hantusch, B; Schlederer, M; Zenz, R; Janig, E; Steiner, G; Meixner, A; Petzelbauer, P; Wolf, P; Soleiman, A; Egger, G; Moriggl, R; Kishimoto, T; Wagner, EF; Kenner, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20423-20428 , 文章类型: Article,,卷期:2009年106-48]
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting various tissues. Involvement of B and T cells as well as increased cytokine levels have been associated with disease manifestation. Recently, w...
- Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival
[作者:Bogunovic, D; O'Neill, DW; Belitskaya-Levy, I; Vacic, V; Yu, YL; Adams, S; Darvishian, F; Berman, R; Shapiro, R; Pavlick, AC; Lonardi, S; Zavadil, J; Osman, I; Bhardwaj, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20429-20434 , 文章类型: Article,,卷期:2009年106-48]
- Although remission rates for metastatic melanoma are generally very poor, some patients can survive for prolonged periods following metastasis. We used gene expression profiling, mitotic index (MI), and quantification of...
- Y chromosome diversity, human expansion, drift, and cultural evolution
[作者:Chiaroni, J; Underhill, PA; Cavalli-Sforza, LL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20174-20179 , 文章类型: Article,,卷期:2009年106-48]
- The relative importance of the roles of adaptation and chance in determining genetic diversity and evolution has received attention in the last 50 years, but our understanding is still incomplete. All statements about th...
- U94 of human herpesvirus 6 inhibits in vitro angiogenesis and lymphangiogenesis
[作者:Caruso, A; Caselli, E; Fiorentini, S; Rotola, A; Prandini, A; Garrafa, E; Saba, E; Alessandri, G; Cassai, E; Di Luca, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20446-20451 , 文章类型: Article,,卷期:2009年106-48]
- Human herpesvirus 6 (HHV-6) is a lymphotropic virus, but recent observations showed that also vascular endothelial cells (ECs) are susceptible to infection, both in vivo and in vitro. The observation that lymph nodes are...
- The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix
[作者:Hinson, ER; Cresswell, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20452-20457 , 文章类型: Article,,卷期:2009年106-48]
- Lipid droplets are intracellular lipid-storage organelles that are thought to be derived from the endoplasmic reticulum (ER). Several pathogens, notably hepatitis C virus, use lipid droplets for replication. Numerous que...
- Metabolic evolution of energy-conserving pathways for succinate production in Escherichia coli
[作者:Zhang, XL; Jantama, K; Moore, JC; Jarboe, LR; Shanmugam, KT; Ingram, LO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20180-20185 , 文章类型: Article,,卷期:2009年106-48]
- During metabolic evolution to improve succinate production in Escherichia coli strains, significant changes in cellular metabolism were acquired that increased energy efficiency in two respects. The energy-conserving pho...
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