- Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release
[作者:Azevedo, C; Burton, A; Ruiz-Mateos, E; Marsh, M; Saiardi, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21161-21166 , 文章类型: Article,,卷期:2009年106-50]
- High-energy inositol pyrophosphates, such as IP7 (diphosphoinositol pentakisphosphate), can directly donate beta-phosphate to a prephosphorylated serine residue generating pyrophosphorylated proteins. Here, we show that ...
- Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role
[作者:Schmaier, AA; Zou, ZY; Kazlauskas, A; Emert-Sedlak, L; Fong, KP; Neeves, KB; Maloney, SF; Diamond, SL; Kunapuli, SP; Ware, J; Brass, LF; Smithgall, TE; Saksela, K; Kahn, ML,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21167-21172 , 文章类型: Article,,卷期:2009年106-50]
- The immune receptor signaling pathway is used by nonimmune cells, but the molecular adaptations that underlie its functional diversification are not known. Circulating platelets use the immune receptor homologue glycopro...
- A theory of microtubule catastrophes and their regulation
[作者:Brun, L; Rupp, B; Ward, JJ; Nedelec, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21173-21178 , 文章类型: Article,,卷期:2009年106-50]
- Dynamic instability, in which abrupt transitions occur between growing and shrinking states, is an intrinsic property of microtubules that is regulated by both mechanics and specialized proteins. We discuss a model of dy...
- MicroRNAs couple cell fate and developmental timing in retina
[作者:Decembrini, S; Bressan, D; Vignali, R; Pitto, L; Mariotti, S; Rainaldi, G; Wang, XM; Evangelista, M; Barsacchi, G; Cremisi, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21179-21184 , 文章类型: Article,,卷期:2009年106-50]
- Cell identity is acquired in different brain structures according to a stereotyped timing schedule, by accommodating the proliferation of multipotent progenitor cells and the generation of distinct types of mature nerve ...
- Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression
[作者:Vollmers, C; Gill, S; DiTacchio, L; Pulivarthy, SR; Le, HD; Panda, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21453-21458 , 文章类型: Article,,卷期:2009年106-50]
- In mammals, the circadian oscillator generates approximately 24-h rhythms in feeding behavior, even under constant environmental conditions. Livers of mice held under constant darkness exhibit circadian rhythm in abundan...
- The diffusion of maize to the southwestern United States and its impact
[作者:Merrill, WL; Hard, RJ; Mabry, JB; Fritz, GJ; Adams, KR; Roney, JR; MacWilliams, AC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21019-21026 , 文章类型: Review,,卷期:2009年106-50]
- Our understanding of the initial period of agriculture in the southwestern United States has been transformed by recent discoveries that establish the presence of maize there by 2100 cal. B. C. (calibrated calendrical ye...
- Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
[作者:Zhang, Q; Shi, Q; Chen, YB; Yue, T; Li, S; Wang, B; Jiang, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21191-21196 , 文章类型: Article,,卷期:2009年106-50]
- The Cul3-based E3 ubiquitin ligases regulate many cellular processes using a large family of BTB domain-containing proteins as their target recognition components, but how they recognize targets remains unknown. Here we ...
- Whiteflies interfere with indirect plant defense against spider mites in Lima bean
[作者:Zhang, PJ; Zheng, SJ; van Loon, JJA; Boland, W; David, A; Mumm, R; Dicke, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21202-21207 , 文章类型: Article,,卷期:2009年106-50]
- Plants under herbivore attack are able to initiate indirect defense by synthesizing and releasing complex blends of volatiles that attract natural enemies of the herbivore. However, little is known about how plants respo...
- Circumpolar synchrony in big river bacterioplankton
[作者:Crump, BC; Peterson, BJ; Raymond, PA; Amon, RMW; Rinehart, A; McClelland, JW; Holmes, RM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21208-21212 , 文章类型: Article,,卷期:2009年106-50]
- Natural bacterial communities are extremely diverse and highly dynamic, but evidence is mounting that the compositions of these communities follow predictable temporal patterns. We investigated these patterns with a 3-ye...
- Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau
[作者:Zhao, M; Kong, QP; Wang, HW; Peng, MS; Xie, XD; Wang, WZ; Jiayang; Duan, JG; Cai, MC; Zhao, SN; Cidanpingcuo; Tu, YQ; Wu, SF; Yao, YG; Bandelt, HJ; Zhang, YP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21230-21235 , 文章类型: Article,,卷期:2009年106-50]
- Due to its numerous environmental extremes, the Tibetan Plateau -the world's highest plateau-is one of the most challenging areas of modern human settlement. Archaeological evidence dates the earliest settlement on the p...
- Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair
[作者:Chen, YH; Choi, K; Szakal, B; Arenz, J; Duan, XY; Ye, H; Branzei, D; Zhao, XL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21252-21257 , 文章类型: Article,,卷期:2009年106-50]
- The evolutionarily conserved Smc5/6 complex is implicated in recombinational repair, but its function in this process has been elusive. Here we report that the budding yeast Smc5/6 complex directly binds to the DNA helic...
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