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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   p53-Mdm2 inhibitors: patent review (2009-2010) [作者：Kamal, A; Mohammed, AA; Shaik, TB,期刊：Expert Opinion on Therapeutic Patents, 页码：95-105 , 文章类型： Review，,卷期：2012年22-2] Introduction: p53 plays a central role in protecting the integrity of the genome. Its activity is ubiquitously lost in cancers, either by inactivation of its protein ( p53 pathway) or by mutation in the p53 gene, thereby... 5-Fluorouracil derivatives: a patent review [作者：Alvarez, P; Marchal, JA; Boulaiz, H; Carrillo, E; Velez, C; Rodriguez-Serrano, F; Melguizo, C; Prados, J; Madeddu, R; Aranega, A,期刊：Expert Opinion on Therapeutic Patents, 页码：107-123 , 文章类型： Review，,卷期：2012年22-2] Introduction: The fluorinated analog of uracil 5-FU is an antimetabolite, active against a wide range of solid tumors. The main mechanism of action consists in interfering with DNA synthesis and mRNA translation. However... Protein tyrosine phosphatase inhibitors: a patent review (2002-2011) [作者：Sobhia, ME; Paul, S; Shinde, R; Potluri, M; Gundam, V; Kaur, A; Haokip, T,期刊：Expert Opinion on Therapeutic Patents, 页码：125-153 , 文章类型： Review，,卷期：2012年22-2] Introduction: The protein tyrosine phosphatases (PTPases or PTPs) are highly conserved phosphatases that regulate the tyrosine phosphorylation and consequently, the cellular functions. Protein tyrosine phosphorylation is... Recent advances in the development of cinnamic-like derivatives as antituberculosis agents [作者：De, P; De, K; Veau, D; Bedos-Belval, F; Chassaing, S; Baltas, M,期刊：Expert Opinion on Therapeutic Patents, 页码：155-168 , 文章类型： Review，,卷期：2012年22-2] Introduction: The high susceptibility of human immunodeficiency virus-infected people to tuberculosis (TB), the emergence of multi-drug-resistant (MDR-TB) strains and extensively drug-resistant (XDR-TB) ones, has brought... Modifications of andrographolide to increase some biological activities: a patent review (2006-2011) [作者：Aromdee, C,期刊：Expert Opinion on Therapeutic Patents, 页码：169-180 , 文章类型： Review，,卷期：2012年22-2] Introduction: Andrographis paniculata Nees, Acanthaceae, is a well-recognised medicinal plant in Asia. It has been reported to possess a variety of biological activities. The main constituent of A. paniculata is androgra... Compositions and methods for treatment of Parkinson's disease: a patent evaluation of WO2011/102847A1 [作者：Chiurchiu, V; Maccarrone, M; Orlacchio, A,期刊：Expert Opinion on Therapeutic Patents, 页码：181-184 , 文章类型： Article，,卷期：2012年22-2] Background: The application (WO2011/102847A1) deals with methods useful for the treatment of Parkinson's disease (PD).Objective: It aims at producing mature and functional midbrain dopaminergic (mDA) neurons useful for t... Novel dihydroquinoline-based MABAs; clues to the identity of LAS-190792: evaluation of WO20111411802 [作者：Norman, P,期刊：Expert Opinion on Therapeutic Patents, 页码：185-192 , 文章类型： Article，,卷期：2012年22-2] Bifunctional aromatic compounds are claimed to contain a beta(2) agonist pharmacophore linked by a flexible lipophilic spacer incorporating a trans-4-aminocyclohexanol group to a muscarinic antagonist pharmacophore. The ... Heterocyclic urea derivatives and methods of use thereof (WO2010142978) [作者：Supuran, CT; Scozzafava, A,期刊：Expert Opinion on Therapeutic Patents, 页码：193-197 , 文章类型： Article，,卷期：2012年22-2] A series of ureido derivatives incorporating a highly derivatized quinolone scaffold were prepared by a succession of original steps. The lead molecules of these compounds are the quinolone antibacterials of the nalidixi...