- Expression of P16, P53 and Ki-67 Proteins in the Progression of Epithelial Dysplasia of the Oral Cavity
[作者:Angiero, F; Berenzi, A; Benetti, A; Rossi, E; Del Sordo, R; Sidoni, A; Stefani, M; Dessy, E,期刊:Anticancer Research, 页码:2535-2539 , 文章类型: Article,,卷期:2008年28-5A]
- Background: The overexpression of the protein products of genes associated with the cell cycle tumour protein53 (p53), cyclin-dependent kinase inhibitor 2A (p16) and antigen identified by monoclonal antibody Ki-67 (Ki-67...
- Human Tumor Growth in Nude Mice Is Associated with Decreased Plasma Cysteine and Homocysteine
[作者:Al-Awadi, F; Yang, M; Tan, YY; Han, QH; Li, SK; Hoffman, RM,期刊:Anticancer Research, 页码:2541-2544 , 文章类型: Article,,卷期:2008年28-5A]
- The methionine cycle and its metabolites homocysteine and cysteine serve several important functions in cellular metabolism. Abnormalities in metabolism of the methionine cycle have been associated with cancer. We determ...
- Bax Expression in Untreated Breast Cancer: An Immunocytometric Study of 255 Cases
[作者:Martinez-Arribas, F; Martin-Garabato, E; Zapardiel, I; Sanchez, J; Lucas, AR; Tejerina, A; Schneider, J,期刊:Anticancer Research, 页码:2595-2598 , 文章类型: Article,,卷期:2008年28-5A]
- Background: Bax is one of the main effectors of apoptosis in breast cancer. However, in contrast with the antiapoptotic protein Bcl-2, which has been extensively studied in this tumor, there are relatively few clinical s...
- Dephosphorylation of Cancer Protein by Tyrosine Phosphatases in Response to Analogs of Luteinizing Hormone-releasing Hormone and Somatostatin
[作者:Lee, LT; Schally, AV; Liebow, C; Lee, PP; Lee, PH; Lee, MT,期刊:Anticancer Research, 页码:2599-2605 , 文章类型: Article,,卷期:2008年28-5A]
- Protein phosphorylation/dephosphorylation of tyrosine residues is an important regulatory mechanism in cell growth and differentiation. Previously it has been reported that RC-160, an octapeptide analog of somatostatin, ...
- Increased Glutathione Level Is not Involved in Enhanced Bleomycin Sensitivity in Cisplatin-resistant 2780(CP) Cells
[作者:Tanaka, T; Kurokawa, H; Matsuno, K; Matsumoto, S; Hayashida, Y,期刊:Anticancer Research, 页码:2663-2668 , 文章类型: Article,,卷期:2008年28-5A]
- The cytotoxic activity of bleomycin (BLM) was evaluated in cisplatin (CDDP)-sensitive (A2780) and resistant (2780(CP)) human ovarian cancer cells, and the mechanism of increased antitumor activity of BLM in the 2780(CP) ...
- Up-regulated p27(Kip1) Reduces Matrix Metalloproteinase-9 and Inhibits Invasion of Human Breast Cancer Cells
[作者:Mizuma, M; Katayose, Y; Yamamoto, K; Shiraso, S; Sasaki, T; Yabuuchi, S; Oda, A; Masuda, K; Rikiyama, T; Onogawa, T; Ohtsuka, H; Motoi, F; Egawa, S; Unno, M,期刊:Anticancer Research, 页码:2669-2677 , 文章类型: Article,,卷期:2008年28-5A]
- Background: p27(Kip1) is a cyclin-dependent kinase inhibitor which has been reported to be associated with invasion, metastasis and angiogenesis in malignant tumors, but its mechanism of action remains unknown. Here, it ...
- Chemopreventive Effects of Heat-processed Panax quinquefolius Root on Human Breast Cancer Cells
[作者:Wang, CZ; Aung, HH; Bin, Z; Sun, S; Li, XL; He, H; Xie, JT; He, TC; Du, W; Yuan, CS,期刊:Anticancer Research, 页码:2545-2551 , 文章类型: Article,,卷期:2008年28-5A]
- Background: Former studies have shown that extract from American ginseng (Panax quinquefolius) may possess certain antiproliferative effects on cancer cells. In this study, the chemical constituents of both untreated and...
- Conserved CPEs in the P53 3 ' Untranslated Region Influence mRNA Stability and Protein Synthesis
[作者:Rosenstierne, MW; Vinther, J; Mittler, G; Larsen, L; Mann, M; Norrild, B,期刊:Anticancer Research, 页码:2553-2559 , 文章类型: Article,,卷期:2008年28-5A]
- Background: The 3' untranslated region (UTR) of p53 mRNA contains two conserved U-rich sequences resembling cytoplasmic polyadenylation elements (CPE). It is not known if these sequences regulate p53 expression by post-t...
- Antitumor Effects of Desmopressin in Combination with Chemotherapeutic Agents in a Mouse Model of Breast Cancer
[作者:Ripoll, GV; Giron, S; Krzymuski, MJ; Hermo, GA; Gomez, DE; Alonso, DF,期刊:Anticancer Research, 页码:2607-2611 , 文章类型: Article,,卷期:2008年28-5A]
- The vasopressin peptide analog desmopressin has been used during surgery to prevent bleeding in patients with coagulation defects. Recent experimental and clinical data revealed that perioperative desmopressin therapy ca...
- The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo
[作者:Palma, JP; Rodriguez, LE; Bontcheva-Diaz, VD; Bouska, JJ; Bukofzer, G; Colon-Lopez, M; Guan, R; Jarvis, K; Johnson, EF; Klinghofer, V; Liu, X; Olson, A; Saltarelli, MJ; Shi, Y; Stavropoulos, JA; Zhu, GD; Penning, TD; Luo, Y; Giranda, VL; Rosenberg, SH; Frost, DJ; Donawho, CK,期刊:Anticancer Research, 页码:2625-2635 , 文章类型: Article,,卷期:2008年28-5A]
- ABT-888 is a potent, orally bioavailable PARP-1/2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo....
- Enhanced Suppression of Melanoma Tumor Growth and Metastasis by Combined Therapy with Anti-VEGF Receptor and Anti-TYRP-1/gp75 Monoclonal Antibodies
[作者:Patel, D; Bassi, R; Hooper, AT; Sun, H; Huber, J; Hicklin, DJ; Kang, XQ,期刊:Anticancer Research, 页码:2679-2686 , 文章类型: Article,,卷期:2008年28-5A]
- Targeted immunotherapy against tumors or angiogenesis has shown promise as an alternative approach for the treatment of malignant disease. Whether or not combining these two treatment modalities would enhance the antitum...
- Variations in Sensitivity to Ionizing Radiation in Relation to p53 Mutation Point
[作者:Okatchi, K; Ide-Kanematsu, M; Izumi, N; Morita, N; Okumura, Y; Ihara, M,期刊:Anticancer Research, 页码:2687-2690 , 文章类型: Article,,卷期:2008年28-5A]
- Mutation of p53 is the most common genetic alteration observed in human tumours and is reported to lead to variations in cell radiosensitivity. However, the relationship between the mutation point and the degree of radio...
- [F-18]FDG and [F-18]FLT PET-CT and MR Imaging of Human Neuroblastomas in a SCID Mouse Xenograft Model
[作者:Valentiner, U; Haane, C; Peldschus, K; Gustke, H; Brenner, W; Wilke, F; Pommert, A; Owsijewitsch, M; Schumacher, U; Klutmann, S,期刊:Anticancer Research, 页码:2561-2568 , 文章类型: Article,,卷期:2008年28-5A]
- Background: Finding new therapeutic agents is of great clinical interest in neuroblastoma research because prognosis of children with disseminated stages of disease is still poor. As xenograft mouse models are frequently...
- Growth Inhibition of Human MDA-MB-231 Breast Cancer Cells by delta-Tocotrienol Is Associated with Loss 9 of Cyclin D1/CDK4 Expression and Accompanying Changes in the State of Phosphorylation of the Retinoblastoma Tumor Suppressor Gene Product
[作者:Elangovan, S; Hsieh, TC; Wu, JM,期刊:Anticancer Research, 页码:2641-2647 , 文章类型: Article,,卷期:2008年28-5A]
- Tocotrienols, a subgroup within the vitamin E family of compounds, have shown antiproliferative and anticancer properties, however, the molecular basis of these effects remains to be elucidated. In this study, the effect...
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