- Farnesoid X Receptor Activation Prevents the Development of Vascular Calcification in ApoE(-/-) Mice With Chronic Kidney Disease
[作者:Miyazaki-Anzai, S; Levi, M; Kratzer, A; Ting, TC; Lewis, LB; Miyazaki, M,期刊:Circulation Research, 页码:1807-1807 , 文章类型: Article,,卷期:2010年106-12]
- Rationale: Vascular calcification is highly associated with cardiovascular morbidity and mortality, especially in patients with chronic kidney disease. The nuclear receptor farnesoid X receptor (FXR) has been implicated ...
- Myocardial Ischemic Preconditioning Preserves Postischemic Function of the 26S Proteasome Through Diminished Oxidative Damage to 19S Regulatory Particle Subunits
[作者:Divald, A; Kivity, S; Wang, P; Hochhauser, E; Roberts, B; Teichberg, S; Gomes, AV; Powell, SR,期刊:Circulation Research, 页码:1829-1829 , 文章类型: Article,,卷期:2010年106-12]
- Rationale: The ubiquitin proteasome system (UPS) becomes dysfunctional as a result of ischemia/reperfusion (I/R), which may lead to dysregulation of signaling pathways. Ischemic preconditioning (IPC) may prevent dysregul...
- Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src-Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity
[作者:Galvagni, F; Pennacchini, S; Salameh, A; Rocchigiani, M; Neri, F; Orlandini, M; Petraglia, F; Gotta, S; Sardone, GL; Matteucci, G; Terstappen, GC; Oliviero, S,期刊:Circulation Research, 页码:1839-1839 , 文章类型: Article,,卷期:2010年106-12]
- Rationale: Integrins cooperate with growth factor receptors to promote downstream signaling for cell proliferation and migration. However, the mechanism of receptor activation is still unknown. Objective: To analyze the ...
- Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart
[作者:Kinoshita, H; Kuwahara, K; Nishida, M; Jian, Z; Rong, XL; Kiyonaka, S; Kuwabara, Y; Kurose, H; Inoue, R; Mori, Y; Li, YH; Nakagawa, Y; Usami, S; Fujiwara, M; Yamada, Y; Minami, T; Ueshima, K; Nakao, K,期刊:Circulation Research, 页码:1849-1849 , 文章类型: Article,,卷期:2010年106-12]
- Rationale: Atrial and brain natriuretic peptides (ANP and BNP, respectively) exert antihypertrophic effects in the heart via their common receptor, guanylyl cyclase (GC)-A, which catalyzes the synthesis of cGMP, leading ...
- ABCA1 and ABCG1 Protect Against Oxidative Stress-Induced Macrophage Apoptosis During Efferocytosis
[作者:Yvan-Charvet, L; Pagler, TA; Seimon, TA; Thorp, E; Welch, CL; Witztum, JL; Tabas, I; Tall, AR,期刊:Circulation Research, 页码:1861-1861 , 文章类型: Article,,卷期:2010年106-12]
- Rationale: Antiatherogenic effects of plasma high-density lipoprotein (HDL) include the ability to inhibit apoptosis of macrophage foam cells. The ATP-binding cassette transporters ABCA1 and ABCG1 have a major role in pr...
- Differential Regulation of Vascular Tone and Remodeling via Stimulation of Type 2 and Type 6 Adenylyl Cyclases in the Ductus Arteriosus
[作者:Yokoyama, U; Minamisawa, S; Katayama, A; Tang, T; Suzuki, S; Iwatsubo, K; Iwasaki, S; Kurotani, R; Okumura, S; Sato, M; Yokota, S; Hammond, HK; Ishikawa, Y,期刊:Circulation Research, 页码:1882-1882 , 文章类型: Article,,卷期:2010年106-12]
- Rationale: Prostaglandin (PG)E-2, which increases intracellular cAMP via activation of adenylyl cyclases (ACs), induces vasodilation and hyaluronan-mediated intimal thickening (IT) in the ductus arteriosus (DA) during la...
- Intramyocardial VEGF-B-167 Gene Delivery Delays the Progression Towards Congestive Failure in Dogs With Pacing-Induced Dilated Cardiomyopathy
[作者:Pepe, M; Mamdani, M; Zentilin, L; Csiszar, A; Qanud, K; Zacchigna, S; Ungvari, Z; Puligadda, U; Moimas, S; Xu, XB; Edwards, JG; Hintze, TH; Giacca, M; Recchia, FA,期刊:Circulation Research, 页码:1893-1893 , 文章类型: Article,,卷期:2010年106-12]
- Rationale: Vascular endothelial growth factor (VEGF)-B selectively binds VEGF receptor (VEGFR)-1, a receptor that does not mediate angiogenesis, and is emerging as a major cytoprotective factor. Objective: To test the hy...
- Human CD34(+) Cells in Experimental Myocardial Infarction Long-Term Survival, Sustained Functional Improvement, and Mechanism of Action
[作者:Wang, JX; Zhang, S; Rabinovich, B; Bidaut, L; Soghomonyan, S; Alauddin, MM; Bankson, JA; Shpall, E; Willerson, JT; Gelovani, JG; Yeh, ETH,期刊:Circulation Research, 页码:1904-1904 , 文章类型: Article,,卷期:2010年106-12]
- Rationale: Human CD34(+) cells have been used in clinical trials for treatment of myocardial infarction (MI). However, it is unknown how long the CD34(+) cells persist in hearts, whether the improvement in cardiac functi...
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