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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共29条记录   Cyclopiazonic Acid Biosynthesis in Aspergillus sp.: Characterization of a Reductase-like R* Domain in Cyclopiazonate Synthetase That Forms and Releases cyclo-Acetoacetyl-L-tryptophan [作者：Liu, XY; Walsh, CT,期刊：Biochemistry, 页码：8746-8757 , 文章类型： Article，,卷期：2009年48-36] The fungal neurotoxin (x-cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca2+-ATPase, has a pentacyclic indole tetramic acid scaffold that arises from one molecule of tryptophan, acetyl-CoA, malonyl-CoA, and dimethyla... Ion-Blocking Sites of the Kir2.1 Channel Revealed by Multiscale Modeling [作者：Tai, KH; Stansfeld, PJ; Sansom, MSP,期刊：Biochemistry, 页码：8758-8763 , 文章类型： Article，,卷期：2009年48-36] The Kir2.1 potassium channel owes its inward-rectifying behavior to blocking by multivalent ions, e.g., magnesium and spermine, which access the channel from the cytoplasm and are thought to bind within the pore. To inve... Arabidopsis thaliana Mitochondrial Glyoxalase 2-1 Exhibits beta-Lactamase Activity [作者：Limphong, P; Nimako, G; Thomas, PW; Fast, W; Makaroff, CA; Crowder, MW,期刊：Biochemistry, 页码：8491-8493 , 文章类型： Article，,卷期：2009年48-36] In an effort to determine the physiological role of Arabidopsis thaliana Glx2-1, we attempted to uncover a substrate for the enzyme. Glx2-1 did not effectively process 192 diverse substrates found in a commercial screen ... Fluconazole Modulates Membrane Rigidity, Heterogeneity, and Water Penetration into the Plasma Membrane in Saccharomyces cerevisiae [作者：Abe, F; Usui, K; Hiraki, T,期刊：Biochemistry, 页码：8494-8504 , 文章类型： Article，,卷期：2009年48-36] Azole anitifungal drugs such as fluconazole inhibit 14 alpha-demethylase. The mechanism of fluconazole action on the plasma membrane is assumed to be ergosterol depletion and accumulation of a toxic sterol, 14 alpha-meth... Activation of Membrane Cholesterol by 63 Amphipaths [作者：Lange, Y; Ye, J; Duban, ME; Steck, TL,期刊：Biochemistry, 页码：8505-8515 , 文章类型： Article，,卷期：2009年48-36] A few membrane-intercalating amphipaths have been observed to stimulate the interaction of cholesterol with cholesterol oxidase, saponin and cyclodextrin, presumably by displacing cholesterol laterally from its phospholi... Temporal Correlation of DNA Binding, ATP Hydrolysis, and Clamp Release in the Clamp Loading Reaction Catalyzed by the Escherichia coli gamma complex [作者：Anderson, SG; Thompson, JA; Paschall, CO; O'Donnell, M; Bloom, LB,期刊：Biochemistry, 页码：8516-8527 , 文章类型： Article，,卷期：2009年48-36] Clamp loaders are multisubunit complexes that use the energy derived from ATP binding and hydrolysis to assemble ring-shaped sliding clamps onto DNA. Sliding clamps in turn tether DNA polymerases to the templates being c... The Cytosolic Half of Helix III Forms the Substrate Exit Route during Permeation Events of the Sodium/Bile Acid Cotransporter ASBT [作者：Hussainzada, N; Da Silva, TC; Swaan, PW,期刊：Biochemistry, 页码：8528-8539 , 文章类型： Article，,卷期：2009年48-36] Site-directed alkylation of consecutively introduced cysteines was employed to probe the solvent-accessible profile of highly conserved transmembrane helix 3 (TM3), spanning residues V127-T149 of the apical sodium-depend... Site-Specific DNA Structural and Dynamic Features Revealed by Nucleotide-Independent Nitroxide Probes [作者：Popova, AM; Kalai, T; Hideg, K; Qin, PZ,期刊：Biochemistry, 页码：8540-8550 , 文章类型： Article，,卷期：2009年48-36] In site-directed spin labeling, a covalently attached nitroxide probe containing a chemically inert unpaired electron is utilized to obtain information on the local environment of the parent macromolecule. Studies presen... The Unfolding of the Prion Protein Sheds Light on the Mechanisms of Prion Susceptibility and Species Barrier [作者：Robinson, PJ; Pinheiro, TJT,期刊：Biochemistry, 页码：8551-8558 , 文章类型： Article，,卷期：2009年48-36] Prion diseases are a group of fatal neurodegenerative disorders that manifest as infectious, sporadic, or familial and are all associated with the misfolding of the prion protein (PrP). Disease-modulating polymorphisms i... N-Terminal Aliphatic Residues Dictate the Structure, Stability, Assembly, and Small Molecule Binding of the Coiled-Coil Region of Cartilage Oligomeric Matrix Protein [作者：Gunasekar, SK; Asnani, M; Limbad, C; Haghpanah, JS; Hom, W; Barra, H; Nanda, S; Lu, M; Montclare, JK,期刊：Biochemistry, 页码：8559-8567 , 文章类型： Article，,卷期：2009年48-36] The coiled-coil domain of cartilage oligomeric matrix protein (COMPcc) assembles into a homopentamer that naturally recognizes the small molecule 1,25-dihydroxyvitamin D-3 (vit D). To identify the residues critical for t... Resonance Raman Spectra of an O-2-Binding H-NOX Domain Reveal Heme Relaxation upon Mutation [作者：Tran, R; Boon, EM; Marletta, MA; Mathies, RA,期刊：Biochemistry, 页码：8568-8577 , 文章类型： Article，,卷期：2009年48-36] Resonance Raman spectra were measured for the wild type Heme-Nitric oxide/OXygen binding domain from Thermoanaerobacter tengcongensis (Tt H-NOX WT) and three other Tt H-NOX proteins containing mutations at key conserved ... F-19 NMR Studies of alpha-Synuclein Conformation and Fibrillation [作者：Li, CG; Lutz, EA; Slade, KM; Ruf, RAS; Wang, GF; Pielak, GJ,期刊：Biochemistry, 页码：8578-8584 , 文章类型： Article，,卷期：2009年48-36] Fibrils of the intrinsically disordered protein alpha-synuclein are hallmarks of Parkinson's disease. The fluorescent dye thioflavin T is often used to characterize fibrillation, but this assay may not provide quantitati... Comparative Photochemistry of Animal Type 1 and Type 4 Cryptochromes [作者：Ozturk, N; Selby, CP; Song, SH; Ye, R; Tan, C; Kao, YT; Zhong, DP; Sancar, A,期刊：Biochemistry, 页码：8585-8593 , 文章类型： Article，,卷期：2009年48-36] Cryptochromes (CRYs) are blue-light photoreceptors with known or presumed functions in light-dependent and light-independent gene regulation in plants and animals. Although the photochemistry of plant CRYs has been studi... Probing the Allosteric Modulator Binding Site of GluR2 with Thiazide Derivatives [作者：Ptak, CP; Ahmed, AH; Oswald, RE,期刊：Biochemistry, 页码：8594-8602 , 文章类型： Article，,卷期：2009年48-36] Ionotropic glutamate receptors mediate the majority of vertebrate excitatory synaptic transmission and are therapeutic targets for cognitive enhancement and treatment of schizophrenia. The binding domains of these tetram... Structural Characterization of the Conformational Change in Calbindin-D-28k upon Calcium Binding Using Differential Surface Modification Analyzed by Mass Spectrometry [作者：Hobbs, CA; Deterding, LJ; Perera, L; Bobay, BG; Thompson, RJ; Darden, TA; Cavanagh, J; Tomer, KB,期刊：Biochemistry, 页码：8603-8614 , 文章类型： Article，,卷期：2009年48-36] Calbindin-D-28k is a calcium binding protein with six EF hand domains. Calbindin-D-28k is unique in that it functions as both a calcium buffer and a sensor protein. It is found in many tissues, including brain, pancreas,... Regulation of the Substrate Preference of p190RhoGAP by Protein Kinase C-Mediated Phosphorylation of a Phospholipid Binding Site [作者：Levay, M; Settleman, J; Ligeti, E,期刊：Biochemistry, 页码：8615-8623 , 文章类型： Article，,卷期：2009年48-36] The Rho family GTPases are stringently regulated through the action of a large family of GTPase activating proteins (GAPs) that stimulate their relatively weak intrinsic GTP hydrolyzing activity. The p190RhoGAPs, which i...