- Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis
[作者：Hu, TS; Liu, SR; Breiter, DR; Wang, F; Tang, Y; Sun, SH,期刊：Cancer research, 页码：6533-6540 , 文章类型： Article，,卷期：2008年68-16]
- Octamer 4 (Oct4), a member of the POU family of transcription factors, plays a key role in the maintenance of pluripotency and proliferation potential of embryonic stein cells. Cancer stein cell-like cells (CSCLC) are re...
- Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
[作者：Concannon, P; Haile, RW; Borresen-Dale, AL; Rosenstein, BS; Gatti, RA; Teraoka, SN; Diep, AT; Jansen, L; Atencio, DP; Langholz, B; Capanu, M; Liang, XL; Begg, CB; Thomas, DC; Bernstein, L; Olsen, JH; Malone, KE; Lynch, CF; Anton-Culver, H; Bernstein, JL,期刊：Cancer research, 页码：6486-6491 , 文章类型： Article，,卷期：2008年68-16]
- Between 5% and 10% of women who survive a first primary breast cancer will subsequently develop a second primary cancer in the contralateral breast. The Women's Environment, Cancer, and Radiation Epidemiology Study was d...
- Chromosome 17q12 variants contribute to risk of early-onset prostate cancer
[作者：Levin, AM; Machiela, NJ; Zuhlke, KA; Ray, AM; Cooney, KA; Douglas, JA,期刊：Cancer research, 页码：6492-6495 , 文章类型： Article，,卷期：2008年68-16]
- In a recent genome-wide association study by Gudmundsson and colleagues, two prostate cancer susceptibility loci were identified on chromosome 17q. The first locus, at 17q12, was distinguished by two intronic single-nucl...
- AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27
[作者：Short, JD; Houston, KD; Dere, R; Cai, SL; Kim, J; Johnson, CL; Broaddus, RR; Shen, JJ; Miyamoto, S; Tamanoi, F; Kwiatkowski, D; Mills, GB; Walker, CL,期刊：Cancer research, 页码：6496-6506 , 文章类型： Article，,卷期：2008年68-16]
- Tuberin, the Tsc2 gene product, integrates the phosphatidylinositol 3-kinase/mitogen-activated protein kinase (mitogenic) and LKBI/AMP-activated protein kinase (AMPK; energy) signaling pathways, and previous independent ...
- BMI-1 promotes Ewing sarcoma tumorigenicity independent of CDKN2A repression
[作者：Douglas, D; Hsu, JHR; Hung, L; Cooper, A; Abdueva, D; van Doorninck, J; Peng, G; Shimada, H; Triche, TJ; Lawlor, ER,期刊：Cancer research, 页码：6507-6515 , 文章类型： Article，,卷期：2008年68-16]
- Deregulation of the polycomb group gene BMI-1 is implicated in the pathogenesis of many human cancers. In this study, we have investigated if the Ewing sarcoma family of tumors (ESFT) expresses BMI-1 and whether it funct...
- S6K1 plays a key role in glial transformation
[作者：Nakamura, JL; Garcia, E; Pieper, RO,期刊：Cancer research, 页码：6516-6523 , 文章类型： Article，,卷期：2008年68-16]
- The mammalian target of rapamycin (mTOR) is a nutrient and ATP sensor suggested to play an important role in tumorigenesis, particularly in the setting of PTEN loss or activated Akt/PKB. Of mTORs two known effectors, eIF...
- CHR-2797: An antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells
[作者：Krige, D; Needham, LA; Bawden, LJ; Flores, N; Farmer, H; Miles, LEC; Stone, E; Callaghan, J; Chandler, S; Clark, VL; Kirwin-Jones, P; Legris, V; Owen, J; Patel, T; Wood, S; Box, G; Laber, D; Odedra, R; Wright, A; Wood, LM; Eccles, SA; Bone, EA; Ayscough, A; Drummond, AH,期刊：Cancer research, 页码：6669-6679 , 文章类型： Article，,卷期：2008年68-16]
- CHR-2797 is a novel metalloenzyme inhibitor that is converted into a pharmacologically active acid product (CHR-79888) inside cells. CHR-79888 is a potent inhibitor of a number of intracellular aminopeptidases, including...
- Identification of a novel recepteur d'origine nantais/c-Met small-molecule kinase inhibitor with antitumor activity in vivo
[作者：Zhang, YH; Kaplan-Lefko, PJ; Rex, K; Yang, YJ; Moriguchi, J; Osgood, T; Mattson, B; Coxon, A; Reese, M; Kim, TS; Lin, J; Chen, A; Burgess, TL; Dussault, I,期刊：Cancer research, 页码：6680-6687 , 文章类型： Article，,卷期：2008年68-16]
- Recepteur dorigine nantais (RON) is a receptor tyrosine kinase closely related to c-Met. Both receptors are involved in cell proliferation, migration, and invasion, and there is evidence that both are deregulated in canc...
- Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function
[作者：Zavareh, RB; Lau, KS; Hurren, R; Datti, A; Ashline, DJ; Gronda, M; Cheung, P; Simpson, CD; Liu, W; Wasylishen, AR; Boutros, PC; Shi, H; Vengopal, A; Jurisica, I; Penn, LZ; Reinhold, VN; Ezzat, S; Wrana, J; Rose, DR; Schachter, H; Dennis, JW; Schimmer, AD,期刊：Cancer research, 页码：6688-6697 , 文章类型： Article，,卷期：2008年68-16]
- Aberrant N-linked glycans promote the malignant potential of cells by enhancing the epithelial-to-mesenchymal transition and the invasive phenotype. To identify small molecule inhibitors of N-glycan biosynthesis, we deve...
- The nuclear factor-kappa B pathway controls the progression of prostate cancer to androgen-independent growth
[作者：Jin, RJ; Lho, YS; Connelly, L; Wang, YQ; Yu, XP; Saint Jean, L; Case, TC; Ellwood-Yen, K; Sawyers, CL; Bhowmick, NA; Blackwell, TS; Yull, FE; Matusik, RJ,期刊：Cancer research, 页码：6762-6769 , 文章类型： Article，,卷期：2008年68-16]
- Typically, the initial response of a prostate cancer patient to androgen ablation therapy is regression of the disease. However, the tumor will progress to an "androgen-independent" stage that results in renewed growth a...
- Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer
[作者：Pallante, P; Federico, A; Berlingieri, MT; Bianco, M; Ferraro, A; Forzati, F; Iaccarino, A; Russo, M; Pierantoni, GM; Leone, V; Sacchetti, S; Troncone, G; Santoro, M; Fusco, A,期刊：Cancer research, 页码：6770-6778 , 文章类型： Article，,卷期：2008年68-16]
- Using gene expression profiling, we found that the CBX7 gene was drastically down-regulated in six thyroid carcinoma cell lines versus control cells. The aims of this study were to determine whether CBX7 is related to th...
- Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells
[作者：Chen, KF; Yeh, PY; Yeh, KH; Lu, YS; Huang, SY; Cheng, AL,期刊：Cancer research, 页码：6698-6707 , 文章类型： Article，,卷期：2008年68-16]
- Bortezomib, a proteasome inhibitor, has been clinically approved for the treatment of myeloma and lymphoma. Here, we report a differential effect of bortezomib on apoptosis in four hepatocellular carcinoma (HCC) cell lin...
- Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress
[作者：Jiang, CC; Lucas, K; Avery-Kiejda, KA; Wade, M; deBock, CE; Thorne, RF; Allen, J; Hersey, P; Zhang, XD,期刊：Cancer research, 页码：6708-6717 , 文章类型： Article，,卷期：2008年68-16]
- We have previously shown that most melanoma cell lines are insensitive to endoplasmic reticulum (ER) stress-induced apoptosis, and this involves activation of the mitogen-activated protein/extracellular signal-regulated ...
- Sp1-mediated TRAIL induction in chemosensitization
[作者：Xu, J; Zhou, JY; Wei, WZ; Philipsen, S; Wu, GS,期刊：Cancer research, 页码：6718-6726 , 文章类型： Article，,卷期：2008年68-16]
- The regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in cancer chemotherapy is not fully understood. Here, we show that the histone deacetylase (HDAC) inhibitors induce TRAIL in human breast ...
- A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin
[作者：Liby, K; Yore, MM; Roebuck, BD; Baumgartner, KJ; Honda, T; Sundararajan, C; Yoshizawa, H; Gribble, GW; Williams, CR; Risingsong, R; Royce, DB; Dinkova-Kostova, AT; Stephenson, KK; Egner, PA; Yates, MS; Groopman, JD; Kensler, TW; Sporn, MB,期刊：Cancer research, 页码：6727-6733 , 文章类型： Article，,卷期：2008年68-16]
- A novel acetylenic tricyclic bis-(cyano enone), TBE-31, is a lead compound in a series of tricyclic compounds with enone functionalities in rings A and C. Nanomolar concentrations of this potent multifunctional molecule ...
|