- Insulin-like Growth Factor 2 Is Required for Progression to Advanced Medulloblastoma in patched1 Heterozygous Mice
[作者:Corcoran, RB; Raveh, TB; Barakat, MT; Lee, EY; Scott, MP,期刊:Cancer research, 页码:8788-8795 , 文章类型: Article,,卷期:2008年68-21]
- Medulloblastoma (MB) can arise in the cerebellum due to genetic activation of the Sonic Hedgehog (Shh) signaling pathway. During normal cerebellum development, Shh spurs the proliferation of granule neuron precursors (GN...
- Estrogen-Related Receptor a Is Critical for the Growth of Estrogen Receptor-Negative Breast Cancer
[作者:Stein, RA; Chang, CY; Kazmin, DA; Way, J; Schroeder, T; Wergin, M; Dewhirst, MW; McDonnell, DP,期刊:Cancer research, 页码:8805-8812 , 文章类型: Article,,卷期:2008年68-21]
- Expression of estrogen-related receptor alpha (ERR(x) has recently been shown to carry negative prognostic significance in breast and ovarian cancers. The specific role of this orphan nuclear receptor in tumor growth and...
- Tumor Regression in Mice by Delivery of Bcl-2 Small Interfering RNA with Pegylated Cationic Liposomes
[作者:Sonoke, S; Ueda, T; Fujiwara, K; Sato, Y; Takagaki, K; Hirabayashi, K; Ohgi, T; Yano, J,期刊:Cancer research, 页码:8843-8851 , 文章类型: Article,,卷期:2008年68-21]
- The pharmacokinetics and antitumor activity of pegylated small interfering RNA (siRNA)/cationic liposome complexes were studied after systemic administration to mice. We designed pegylated-lipid carriers for achieving in...
- Identification of Pbx1, a Potential Oncogene, as a Notch3 Target Gene in Ovarian Cancer
[作者:Park, JT; Shih, IM; Wang, TL,期刊:Cancer research, 页码:8852-8860 , 文章类型: Article,,卷期:2008年68-21]
- Notch3 gene amplification has recently been identified in ovarian cancer but the Notch3 effectors that are involved in the development of ovarian cancer remain elusive. In this study, we have identified Pbx1, a proto-onc...
- Modification of Cysteine Residue in p65 Subunit of Nuclear Factor-kappa B (NF-kappa B) by Picroliv Suppresses NF-kappa B-Regulated Gene Products and Potentiates Apoptosis
[作者:Anand, P; Kunnumakkara, AB; Harikumar, KB; Ahn, KS; Badmaev, V; Aggarwal, BB,期刊:Cancer research, 页码:8861-8870 , 文章类型: Article,,卷期:2008年68-21]
- Picroliv, an iridoid glycoside derived from the plant Picrorhiza kurroa, is used traditionally to treat fever, asthma, hepatitis, and other inflammatory conditions. However, the exact mechanism of its therapeutic action ...
- Prevalence, Acquisition, and Clearance of Cervical Human Papillomavirus Infection among Women with Normal Cytology: Hawaii Human Papillomavirus Cohort Study
[作者:Goodman, MT; Shvetsov, YB; McDuffie, K; Wilkens, LR; Zhu, XM; Thompson, PJ; Ning, L; Killeen, J; Kamemoto, L; Hernandez, BY,期刊:Cancer research, 页码:8813-8824 , 文章类型: Article,,卷期:2008年68-21]
- Few natural history studies of cervical human papillomavirus (HPV) incidence and duration have been conducted among older women, especially from multiethnic populations. Viral and nonviral determinants of HPV acquisition...
- Routine Diagnostic X-ray Examinations and Increased Frequency of Chromosome Translocations among US Radiologic Technologists
[作者:Sigurdson, AJ; Bhatti, P; Preston, DL; Doody, MM; Karnpa, D; Alexander, BH; Petibone, D; Yong, LC; Edwards, AA; Ron, E; Tucker, JD,期刊:Cancer research, 页码:8825-8831 , 文章类型: Article,,卷期:2008年68-21]
- The U.S. population has nearly one radiographic examination per person per year, and concern about cancer risks associated with medical radiation has increased. Radiologic technologists were surveyed to determine whether...
- Gestational Hypertension, Preeclampsia, and Risk of Testicular Cancer
[作者:Pettersson, A; Richiardi, L; Cnattingius, S; Kaijser, M; Akre, O,期刊:Cancer research, 页码:8832-8836 , 文章类型: Article,,卷期:2008年68-21]
- Altered levels of pregnancy hormones have been suggested to initiate testicular cancer prenatally in the male fetus. The placenta is the main source of pregnancy hormones, and pregnancy hypertension and preeclampsia are ...
- Association Study of Prostate Cancer Susceptibility Variants with Risks of Invasive Ovarian, Breast, and Colorectal Cancer
[作者:Song, HL; Koessler, T; Ahmed, S; Ramus, SJ; Kjaer, SK; Dicioccio, RA; Wozniak, E; Hogdall, E; Whittemore, AS; McGuire, V; Ponder, BAJ; Turnbull, C; Hines, S; Rahman, N; Eeles, RA; Easton, DF; Gayther, SA; Dunning, AM; Pharoah, PDP,期刊:Cancer research, 页码:8837-8842 , 文章类型: Article,,卷期:2008年68-21]
- Several prostate cancer susceptibility loci have recently been identified by genome-wide association studies. These loci are candidates for susceptibility to other epithelia] cancers. The aim of this study was to test th...
- Targeting YB-1 in HER-2 Overexpressing Breast Cancer Cells Induces Apoptosis via the mTOR/STAT3 Pathway and Suppresses Tumor Growth in Mice
[作者:Lee, C; Dhillon, J; Wang, MYC; Gao, YY; Hu, KJ; Park, E; Astanehe, A; Hung, MC; Eirew, P; Eaves, CJ; Dunn, SE,期刊:Cancer research, 页码:8661-8666 , 文章类型: Article,,卷期:2008年68-21]
- The Y-box binding protein-1 (YB-1) is a transcription/translation factor that is highly expressed in primary breast tumors where it is consistently associated with poor survival. It induces human epidermal growth factor ...
- Neuropilin-1 Upholds Dedifferentiation and Propagation Phenotypes of Renal Cell Carcinoma Cells by Activating Akt and Sonic Hedgehog Axes
[作者:Cao, Y; Wang, L; Nandy, D; Zhang, Y; Basu, A; Radisky, D; Mukhopadhyay, D,期刊:Cancer research, 页码:8667-8672 , 文章类型: Article,,卷期:2008年68-21]
- Expression of neuropilin-1 (NTRP-1) has been shown in many cancer cells, but its molecular effect on tumorigenesis is largely unknown. In this report, we show that in aggressive types of renal cell carcinoma (RCC), NRP-1...
- Tandem Duplication Producing a Novel Oncogenic BRAF Fusion Gene Defines the Majority of Pilocytic Astrocytomas
[作者:Jones, DTW; Kocialkowski, S; Liu, L; Pearson, DM; Backlund, LM; Ichimura, K; Collins, VP,期刊:Cancer research, 页码:8673-8677 , 文章类型: Article,,卷期:2008年68-21]
- Brain tumors are the most common solid tumors of childhood, and pilocytic astrocytomas (PA) are the most common central nervous system tumor in 5 to 19 year olds. Little is known about the genetic alterations underlying ...
- Bryostatin-5 Blocks Stromal Cell-Derived Factor-1 Induced Chemotaxis via Desensitization and Down-regulation of Cell Surface CXCR4 Receptors
[作者:He, X; Fang, LY; Wang, J; Yi, YH; Zhang, SY; Xie, X,期刊:Cancer research, 页码:8678-8686 , 文章类型: Article,,卷期:2008年68-21]
- The chemokine receptor CXCR4 and its ligand, stromal cell-derived factor-1 (SDF-1), play important roles in hematopolesis regulation, lymphocyte activation, and trafficking, as well as in developmental processes, includi...
- Endogenous Interleukin-4 Promotes Tumor Development by increasing Tumor Cell Resistance to Apoptosis
[作者:Li, ZG; Jiang, J; Wang, ZB; Zhang, JH; Xiao, MJ; Wang, CH; Lu, Y; Qin, ZH,期刊:Cancer research, 页码:8687-8694 , 文章类型: Article,,卷期:2008年68-21]
- The increase of interleukin-4 (IL-A) level in tumor environment and the up-regulation of IL-4 receptor (IL-4R) on tumor cells have been long observed. However, their significance for tumor development has not been invest...
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