- Transient Potent BCR-ABL Inhibition Is Sufficient to Commit Chronic Myeloid Leukemia Cells Irreversibly to Apoptosis
[作者：Shah, NP; Kasap, C; Weier, C; Balbas, M; Nicoll, JM; Bleickardt, E; Nicaise, C; Sawyers, CL,期刊：Cancer Cell, 页码：485-493 , 文章类型： Article，,卷期：2008年14-6]
- The BCR-ABL inhibitor dasatinib achieves clinical remissions in chronic myeloid leukemia (CML) patients using a dosing schedule that achieves potent but transient BCR-ABL inhibition. In vitro, transient potent BCR-ABL in...
- Kidney Cancer: Now Available in a New Flavor
[作者：Kaelin, WG,期刊：Cancer Cell, 页码：423-424 , 文章类型： Editorial Material，,卷期：2008年14-6]
- The role of the von Hippel-Lindau tumor suppressor protein (pVHL) in kidney cancer has provided a rationale for treating this disease with hypoxia-inducible factor (HIF) antagonists. In this issue, Simon and coworkers sh...
- Ratcheting Myc
[作者：Freie, BW; Eisenman, RN,期刊：Cancer Cell, 页码：425-426 , 文章类型： Editorial Material，,卷期：2008年14-6]
- In this issue of Cancer Cell, Murphy et al. describe a mouse model designed to examine the biological effects of different levels of deregulated c-myc expression. They provide evidence that distinct threshold levels of M...
- AKT and Oxidative Stress Team Up to Kill Cancer Cells
[作者：Dolado, I; Nebreda, AR,期刊：Cancer Cell, 页码：427-429 , 文章类型： Editorial Material，,卷期：2008年14-6]
- AKT, a protein kinase frequently hyperactivated in cancer, plays an important role in cell survival and contributes to tumor cell resistance to cytotoxic therapies. A new study in this issue of Cancer Cell shows that AKT...
- The Aneuploidy Paradox in Cell Growth and Tumorigenesis
[作者：Weaver, BA; Cleveland, DW,期刊：Cancer Cell, 页码：431-433 , 文章类型： Editorial Material，,卷期：2008年14-6]
- Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of Science, Williams et al. identified a parad...
- HIF-alpha Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
[作者：Gordan, JD; Lal, P; Dondeti, VR; Letrero, R; Parekh, KN; Oquendo, CE; Greenberg, RA; Flaherty, KT; Rathmell, WK; Keith, B; Simon, MC; Nathanson, KL,期刊：Cancer Cell, 页码：435-446 , 文章类型： Article，,卷期：2008年14-6]
- von Hippel-Lindau (VHL) tumor suppressor loss results in hypoxia-inducible factor alpha (HIF-alpha) stabilization and occurs in 70% of sporadic clear cell renal carcinomas (ccRCCs). To determine whether opposing influenc...
- Overexpression of Interleukin-1 beta Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice (vol 14, pg 408, 2008)
[作者：Tu, SP; Bhagat, G; Cui, GL; Takaishi, S; Kurt-Jones, EA; Rickman, B; Betz, KS; Penz-Oesterreicher, M; Bjorkdahl, O; Fox, JG; Wang, TC,期刊：Cancer Cell, 页码：494-494 , 文章类型： Correction，,卷期：2008年14-6]
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- Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis
[作者：Nogueira, V; Park, Y; Chen, CC; Xu, PZ; Chen, ML; Tonic, I; Unterman, T; Hay, N,期刊：Cancer Cell, 页码：458-470 , 文章类型： Article，,卷期：2008年14-6]
Akt deficiency causes resistance to replicative senescence, to oxidative stress- and oncogenic Ras-induced premature senescence, and to reactive oxygen species (ROS)-mediated apoptosis. Akt activation induces prematur...
- Hepatic Stem-like Phenotype and Interplay of Wnt/beta-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer
[作者：Cairo, S; Armengol, C; De Reynies, A; Wei, Y; Thomas, E; Renard, CA; Goga, A; Balakrishnan, A; Semeraro, M; Gresh, L; Pontoglio, M; Strick-Marchand, H; Levillayer, F; Nouet, Y; Rickman, D; Gauthier, F; Branchereau, S; Brugieres, L; Laithier, V; Bouvier, R; Boman, F; Basso, G; Michiels, JF; Hofman, P; Arbez-Gindre, F; Jouan, H; Chapeau, MCR; Berrebi, D; Marcellin, L; Plenat, F; Zachar, D; Joubert, M; Selves, J; Pasquier, D; Bioulac-Sage, P; Grotzer, M; Childs, M; Fabre, M; Buendia, MA,期刊：Cancer Cell, 页码：471-484 , 文章类型： Article，,卷期：2008年14-6]
- Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver de...
- Distinct Thresholds Govern Myc's Biological Output In Vivo
[作者：Murphy, DJ; Junttila, MR; Pouyet, L; Karnezis, A; Shchors, K; Bui, DA; Brown-Swigart, L; Johnson, L; Evan, GI,期刊：Cancer Cell, 页码：447-457 , 文章类型： Article，,卷期：2008年14-6]
- Deregulated Myc triggers a variety of intrinsic tumor suppressor programs that serve to restrain Myc's oncogenic potential. Since Myc activity is also required for normal cell proliferation, activation of intrinsic tumor...
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