- alpha B-Crystallin Polydispersity Is a Consequence of Unbiased Quaternary Dynamics
[作者:Baldwin, AJ; Lioe, H; Robinson, CV; Kay, LE; Benesch, JLP,期刊:Journal of Molecular Biology, 页码:297-309 , 文章类型: Article,,卷期:2011年413-2]
- The inherent heterogeneity of many protein assemblies complicates characterization of their structure and dynamics, as most biophysical techniques require homogeneous preparations of isolated components. For this reason,...
- Quaternary Dynamics of alpha B-Crystallin as a Direct Consequence of Localised Tertiary Fluctuations in the C-Terminus
[作者:Baldwin, AJ; Hilton, GR; Lioe, H; Bagneris, C; Benesch, JLP; Kay, LE,期刊:Journal of Molecular Biology, 页码:310-320 , 文章类型: Article,,卷期:2011年413-2]
- The majority of proteins exist in vivo within macromolecular assemblies whose functions are dependent on dynamical processes spanning a wide range of time scales. One such assembly is formed by the molecular chaperone al...
- Role of Interaction of XPF with RPA in Nucleotide Excision Repair
[作者:Fisher, LA; Bessho, M; Wakasugi, M; Matsunaga, T; Bessho, T,期刊:Journal of Molecular Biology, 页码:337-346 , 文章类型: Article,,卷期:2011年413-2]
- Nucleotide excision repair (NER) is a very important defense system against various types of DNA damage, and it is necessary for maintaining genomic stability. The molecular mechanism of NER has been studied in considera...
- Roles of Carboxyl Groups in the Transmembrane Insertion of Peptides
[作者:Barrera, FN; Weerakkody, D; Anderson, M; Andreev, OA; Reshetnyak, YK; Engelman, DM,期刊:Journal of Molecular Biology, 页码:359-371 , 文章类型: Article,,卷期:2011年413-2]
- We have used pHLIP (R) [pH (low) insertion peptide] to study the roles of carboxyl groups in transmembrane (TM) peptide insertion. pHLIP binds to the surface of a lipid bilayer as a disordered peptide at neutral pH; when...
- RGK Family G-Domain:GTP Analog Complex Structures and Nucleotide-Binding Properties
[作者:Sasson, Y; Navon-Perry, L; Huppert, D; Hirsch, JA,期刊:Journal of Molecular Biology, 页码:372-389 , 文章类型: Article,,卷期:2011年413-2]
- The RGK family of small G-proteins, including Rad, Gem, Rem1, and Rem2, is inducibly expressed in various mammalian tissues and interacts with voltage-dependent calcium channels and Rho kinase. Many questions remain rega...
- Inhibition of Cullin RING Ligases by Cycle Inhibiting Factor: Evidence for Interference with Nedd8-Induced Conformational Control
[作者:Boh, BK; Ng, MY; Leck, YC; Shaw, B; Long, J; Sun, GW; Gan, YH; Searle, MS; Layfield, R; Hagen, T,期刊:Journal of Molecular Biology, 页码:430-437 , 文章类型: Article,,卷期:2011年413-2]
- Cycle inhibiting factor (Cif) is produced by pathogenic intracellular bacteria and injected into the host cells via a type III secretion system. Cif is known to interfere with the eukaryotic cell cycle by inhibiting the ...
- A New Structural Form in the SAM/Metal-Dependent O-Methyltransferase Family: MycE from the Mycinamicin Biosynthetic Pathway
[作者:Akey, DL; Li, SY; Konwerski, JR; Confer, LA; Bernard, SM; Anzai, Y; Kato, F; Sherman, DH; Smith, JL,期刊:Journal of Molecular Biology, 页码:438-450 , 文章类型: Article,,卷期:2011年413-2]
- O-linked methylation of sugar substituents is a common modification in the biosynthesis of many natural products and is catalyzed by multiple families of S-adenosyl-L-methionine (SAM or AdoMet)-dependent methyltransferas...
|