- The Overall Architecture and Receptor Binding of Pneumococcal Carbohydrate-Antigen-Hydrolyzing Enzymes
[作者:Higgins, MA; Ficko-Blean, E; Meloncelli, PJ; Lowary, TL; Boraston, AB,期刊:Journal of Molecular Biology, 页码:1017-1036 , 文章类型: Article,,卷期:2011年411-5]
- The TIGR4 and SP3-BS71 strains of Streptococcus pneumoniae each produce family 98 glycoside hydrolases, called Sp4GH98 and Sp3GH98, respectively, which have different modular architectures and substrate specificities. Sp...
- The Nonlinear Structure of the Desmoplakin Plakin Domain and the Effects of Cardiomyopathy-Linked Mutations
[作者:Al-Jassar, C; Knowles, T; Jeeves, M; Kami, K; Behr, E; Bikker, H; Overduin, M; Chidgey, M,期刊:Journal of Molecular Biology, 页码:1049-1061 , 文章类型: Article,,卷期:2011年411-5]
- Desmoplakin is a cytoplasmic desmosomal protein that plays a vital role in normal intercellular adhesion. Mutations in desmoplakin can result in devastating skin blistering diseases and arrhythmogenic right ventricular c...
- Nonlinear Viscoelasticity of Actin Transiently Cross-linked with Mutant alpha-Actinin-4
[作者:Yao, NY; Becker, DJ; Broedersz, CP; Depken, M; MacKintosh, FC; Pollak, MR; Weitz, DA,期刊:Journal of Molecular Biology, 页码:1062-1071 , 文章类型: Article,,卷期:2011年411-5]
- Filamentous actin and associated actin binding proteins play an essential role in governing the mechanical properties of eukaryotic cells. They can also play a critical role in disease; for example, mutations in alpha-ac...
- The Crystal Structure of Zebrafish S100Z: Implications for Calcium-Promoted S100 Protein Oligomerisation
[作者:Moroz, OV; Bronstein, IB; Wilson, KS,期刊:Journal of Molecular Biology, 页码:1072-1082 , 文章类型: Article,,卷期:2011年411-5]
- The S100 family, with about 20 members in humans, is composed of EF-hand calcium-regulated proteins and is linked to a range of serious human diseases, including cancer and autoimmune and neurological disorders. The olde...
- The Four Hydrophobic Residues on the Hsp70 Inter-Domain Linker Have Two Distinct Roles
[作者:Kumar, DP; Vorvis, C; Sarbeng, EB; Ledesma, VCC; Willis, JE; Liu, QL,期刊:Journal of Molecular Biology, 页码:1099-1113 , 文章类型: Article,,卷期:2011年411-5]
- The ubiquitous molecular chaperone 70-kDa heat shock proteins (Hsp70) play key roles in maintaining protein homeostasis. Hsp70s contain two functional domains: a nucleotide binding domain and a substrate binding domain. ...
- The Structure of BRMS1 Nuclear Export Signal and SNX6 Interacting Region Reveals a Hexamer Formed by Antiparallel Coiled Coils
[作者:Spinola-Amilibia, M; Rivera, J; Ortiz-Lombardia, M; Romero, A; Neira, JL; Bravo, J,期刊:Journal of Molecular Biology, 页码:1114-1127 , 文章类型: Article,,卷期:2011年411-5]
- We present here the first structural report derived from breast cancer metastasis suppressor 1 (BRMS1), a member of the metastasis suppressor protein group, which, during recent years, have drawn much attention since the...
- Structure of H/ACA RNP Protein Nhp2p Reveals Cis/Trans Isomerization of a Conserved Proline at the RNA and Nop10 Binding Interface
[作者:Koo, BK; Park, CJ; Fernandez, CF; Chim, N; Ding, Y; Chanfreau, G; Feigon, J,期刊:Journal of Molecular Biology, 页码:927-942 , 文章类型: Article,,卷期:2011年411-5]
- H/ACA small nucleolar and Cajal body ribonucleoproteins (RNPs) function in site-specific pseudouridylation of eukaryotic rRNA and snRNA, rRNA processing, and vertebrate telomerase biogenesis. Nhp2, one of four essential ...
- Crystal Structure of Serratia fonticola Sfh-I: Activation of the Nucleophile in Mono-Zinc Metallo-beta-Lactamases
[作者:Fonseca, F; Bromley, EHC; Saavedra, MJ; Correia, A; Spencer, J,期刊:Journal of Molecular Biology, 页码:951-959 , 文章类型: Article,,卷期:2011年411-5]
- Metallo-p,-lactamases (MBLs) or class B beta-lactamases are zinc-dependent enzymes capable of inactivating almost all classes of beta-lactam antibiotics. To date, no MBL inhibitors are available for clinical use. Of the ...
- Characterization of the Endoribonuclease Active Site of Human Apurinic/Apyrimidinic Endonuclease 1
[作者:Kim, WC; Berquist, BR; Chohan, M; Uy, C; Wilson, DM; Lee, CH,期刊:Journal of Molecular Biology, 页码:960-971 , 文章类型: Article,,卷期:2011年411-5]
- Apurinic/apyrimidinic endonuclease 1 (APE1) is the major mammalian enzyme in DNA base excision repair that cleaves the DNA phosphodiester backbone immediately 5' to abasic sites. Recently, we identified APE1 as an endori...
- Characterization of a Dual-Function Domain That Mediates Membrane Insertion and Excision of Ff Filamentous Bacteriophage
[作者:Bennett, NJ; Gagic, D; Sutherland-Smith, AJ; Rakonjac, J,期刊:Journal of Molecular Biology, 页码:972-985 , 文章类型: Article,,卷期:2011年411-5]
- The filamentous phage Ff (f1, fd, or M13) of Escherichia coli is assembled at the cell membranes by a process that is morphologically similar to that of pilus assembly. The release of the filament virion is mediated by e...
- Crystal Structure of the Eukaryotic Light-Driven Proton-Pumping Rhodopsin, Acetabularia Rhodopsin II, from Marine Alga
[作者:Wada, T; Shimono, K; Kikukawa, T; Hato, M; Shinya, N; Kim, SY; Kimura-Someya, T; Shirouzu, M; Tamogami, J; Miyauchi, S; Jung, KH; Kamo, N; Yokoyama, S,期刊:Journal of Molecular Biology, 页码:986-998 , 文章类型: Article,,卷期:2011年411-5]
- Acetabularia rhodopsin (AR) is a rhodopsin from the marine plant Acetabularia acetabulum. The opsin-encoding gene from A. acetabulum, ARII, was cloned and found to be novel but homologous to that reported previously. ARI...
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