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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   In Vivo and In Vitro Analyses of Toxic Mutants of HET-s: FTIR Antiparallel Signature Correlates with Amyloid Toxicity [作者：Berthelot, K; Ta, HP; Gean, J; Lecomte, S; Cullin, C,期刊：Journal of Molecular Biology, 页码：137-152 , 文章类型： Article，,卷期：2011年412-1] The folding and interactions of amyloid proteins are at the heart of the debate as to how these proteins may or may not become toxic to their host. Although little is known about this issue, the structure seems to be cle... Crystal Structure of the Cytoplasmic N-Terminal Domain of Subunit I, a Homolog of Subunit a, of V-ATPase [作者：Srinivasan, S; Vyas, NK; Baker, ML; Quiocho, FA,期刊：Journal of Molecular Biology, 页码：14-21 , 文章类型： Article，,卷期：2011年412-1] Subunit "a" is associated with the membrane-bound (V(O)) complex of eukaryotic vacuolar H(+)-ATPase acidification machinery. It has also been shown recently to be involved in diverse membrane fusion/secretory functions i... A Crystallographic Study of the Role of Sequence Context in Thymine Glycol Bypass by a Replicative DNA Polymerase Serendipitously Sheds Light on the Exonuclease Complex [作者：Aller, P; Duclos, S; Wallace, SS; Doublie, S,期刊：Journal of Molecular Biology, 页码：22-34 , 文章类型： Article，,卷期：2011年412-1] Thymine glycol (Tg) is the most common oxidation product of thymine and is known to be a strong block to replicative DNA polymerases. A previously solved structure of the bacteriophage RB69 DNA polymerase (RB69 gp43) in ... The Molecular Basis of the Caskin1 and Mint1 Interaction with CASK [作者：Stafford, RL; Ear, J; Knight, MJ; Bowie, JU,期刊：Journal of Molecular Biology, 页码：3-13 , 文章类型： Article，,卷期：2011年412-1] Calcium/calmodulin-dependent serine protein kinase (CASK) is a conserved multi-domain scaffolding protein involved in brain development, synapse formation, and establishment of cell polarity. To accomplish these diverse ... The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin [作者：Nawrotek, A; Knossow, M; Gigant, B,期刊：Journal of Molecular Biology, 页码：35-42 , 文章类型： Article，,卷期：2011年412-1] Tubulin alternates between a soluble curved structure and a microtubule straight conformation. GTP binding to alpha beta-tubulin is required for microtubule assembly, but whether this triggers conversion into a straighte... High-Throughput Selection of Transmembrane Sequences That Enhance Receptor Tyrosine Kinase Activation [作者：He, LJ; Hoffmann, AR; Serrano, C; Hristova, K; Wimley, WC,期刊：Journal of Molecular Biology, 页码：43-54 , 文章类型： Article，,卷期：2011年412-1] Dimerization is a critical requirement for the activation of the intracellular kinase domains of receptor tyrosine kinases (RTKs). The single transmembrane (TM) helices of RTKs contribute to dimerization, but the details... Synthetic Antibodies Designed on Natural Sequence Landscapes [作者：Zhai, WW; Glanville, J; Fuhrmann, M; Mei, L; Ni, I; Sundar, PD; Van Blarcom, T; Abdiche, Y; Lindquist, K; Strohner, R; Telman, D; Cappuccilli, G; Finlay, WJJ; Van den Brulle, J; Cox, DR; Pons, J; Rajpal, A,期刊：Journal of Molecular Biology, 页码：55-71 , 文章类型： Article，,卷期：2011年412-1] We present a method for synthetic antibody library generation that combines the use of high-throughput immune repertoire analysis and a novel synthetic technology. The library design recapitulates positional amino acid f... Two-Dimensional Kinetics of Inter-Connexin Interactions from Single-Molecule Force Spectroscopy [作者：Rico, F; Oshima, A; Hinterdorfer, P; Fujiyoshi, Y; Scheuring, S,期刊：Journal of Molecular Biology, 页码：72-79 , 文章类型： Article，,卷期：2011年412-1] Gap junction channels are intercellular channels that form by docking the extracellular loops of connexin protein subunits. While the structure and function of-gap junctions as intercellular channels have been characteri... Crystal Structure of Inulosucrase from Lactobacillus: Insights into the Substrate Specificity and Product Specificity of GH68 Fructansucrases [作者：Pijning, T; Anwar, MA; Boger, M; Dobruchowska, JM; Leemhuis, H; Kralj, S; Dijkhuizen, L; Dijkstra, BW,期刊：Journal of Molecular Biology, 页码：80-93 , 文章类型： Article，,卷期：2011年412-1] Fructansucrases (FSs) catalyze a transfructosylation reaction with sucrose as substrate to produce fructo-oligosaccharides and fructan polymers that contain either beta-2,1 glycosidic linkages (inulin) or beta-2,6 linkag... Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities [作者：Webber, PJ; Smith, AD; Sen, S; Renfrow, MB; Mobley, JA; West, AB,期刊：Journal of Molecular Biology, 页码：94-110 , 文章类型： Article，,卷期：2011年412-1] The leucine-rich repeat kinase 2 (LRRK2) protein has both guanosine triphosphatase (GTPase) and kinase activities, and mutation in either enzymatic domain can cause late-onset Parkinson disease. Nucleotide binding in the... A Versatile Player [作者：Hsueh, YP,期刊：Journal of Molecular Biology, 页码：1-2 , 文章类型： Editorial Material，,卷期：2011年412-1] Engineering GST M2-2 for High Activity with Indene 1,2-Oxide and Indication of an H-Site Residue Sustaining Catalytic Promiscuity [作者：Norrgard, MA; Mannervik, B,期刊：Journal of Molecular Biology, 页码：111-120 , 文章类型： Article，,卷期：2011年412-1] The substrate-binding H-site of human glutathione transferase (GST) M2-2 was subjected to iterative saturation mutagenesis in order to obtain an efficient enzyme with the novel epoxide substrate indene 1,2-oxide. Residue... Structural Characterization of Polyglutamine Fibrils by Solid-State NMR Spectroscopy [作者：Schneider, R; Schumacher, MC; Mueller, H; Nand, D; Klaukien, V; Heise, H; Riedel, D; Wolf, G; Behrmann, E; Raunser, S; Seidel, R; Engelhard, M; Baldus, M,期刊：Journal of Molecular Biology, 页码：121-136 , 文章类型： Article，,卷期：2011年412-1] Protein aggregation via polyglutamine stretches occurs in a number of severe neurodegenerative diseases such as Huntington's disease. We have investigated fibrillar aggregates of polyglutamine peptides below, at, and abo...