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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Who Initiates Proteasomal Degradation? [作者：Gsponer, J,期刊：Journal of Molecular Biology, 页码：317-318 , 文章类型： Editorial Material，,卷期：2011年412-3] Intrinsic Disorder in Ubiquitination Substrates [作者：Hagai, T; Azia, A; Toth-Petroczy, A; Levy, Y,期刊：Journal of Molecular Biology, 页码：319-324 , 文章类型： Article，,卷期：2011年412-3] The ubiquitin-proteasome system is responsible for the degradation of numerous proteins in eukaryotes. Degradation is an essential process in many cellular pathways and involves the proteasome degrading a wide variety of... Exploring the Roles of Nucleobase Desolvation and Shape Complementarity during the Misreplication of O(6)-Methylguanine [作者：Chavarria, D; Ramos-Serrano, A; Hirao, I; Berdis, AJ,期刊：Journal of Molecular Biology, 页码：325-339 , 文章类型： Article，,卷期：2011年412-3] O(6)-methylguanine (O(6)-MeG) is a miscoding DNA lesion arising from the alkylation of guanine. This report uses the bacteriophage T4 DNA polymerase as a model to probe the roles of hydrogen-bonding interactions, shape/s... Polymerase Chaperoning and Multiple ATPase Sites Enable the E. coli DNA Polymerase III Holoenzyme to Rapidly Form Initiation Complexes [作者：Downey, CD; Crooke, E; McHenry, CS,期刊：Journal of Molecular Biology, 页码：340-353 , 文章类型： Article，,卷期：2011年412-3] Cellular replicases include three subassemblies: a DNA polymerase, a sliding clamp processivity factor, and a clamp loader complex. The Escherichia coli clamp loader is the DnaX complex (DnaX(3)delta delta'chi psi), wher... HIV-1 Reverse Transcriptase Dissociates during Strand Transfer [作者：Muchiri, JM; Rigby, ST; Nguyen, LA; Kim, B; Bambara, RA,期刊：Journal of Molecular Biology, 页码：354-364 , 文章类型： Article，,卷期：2011年412-3] Steps in the replication of human immunodeficiency virus type 1 (HIV-1) occurring in the virus but not in the host are preferred targets of antiretroviral therapy. Strand transfer is unique; the DNA strand being made by ... Differential Turnover of Myosin Chaperone UNC-45A Isoforms Increases in Metastatic Human Breast Cancer [作者：Guo, W; Chen, DS; Fan, Z; Epstein, HF,期刊：Journal of Molecular Biology, 页码：365-378 , 文章类型： Article，,卷期：2011年412-3] UNC-45A is a molecular chaperone targeted to non-muscle myosins and is essential for cell division. Here, we show that UNC-45A mRNA and protein expression was elevated in human breast carcinomas and cell lines derived fr... The N-Terminal Domains of Myosin Binding Protein C Can Bind Polymorphically to F-Actin [作者：Orlova, A; Galkin, VE; Jeffries, CMJ; Egelman, EH; Trewhella, J,期刊：Journal of Molecular Biology, 页码：379-386 , 文章类型： Article，,卷期：2011年412-3] The regulation of vertebrate striated muscle contraction involves a number of different molecules, including the thin-filament accessory proteins tropomyosin and troponin that provide Ca(2+)-dependent regulation by contr... In Vitro Assembly of the empty setX174 Procapsid from External Scaffolding Protein Oligomers and Early Pentameric Assembly Intermediates [作者：Cherwa, JE; Organtini, LJ; Ashley, RE; Hafenstein, SL; Fane, BA,期刊：Journal of Molecular Biology, 页码：387-396 , 文章类型： Article，,卷期：2011年412-3] Bacteriophage empty setX174 morphogenesis requires two scaffolding proteins: an internal species, similar to those employed in other viral systems, and an external species, which is more typically associated with satelli... Structural Basis of Binding by Cyclic Nonphosphorylated Peptide Antagonists of Grb7 Implicated in Breast Cancer Progression [作者：Ambaye, ND; Pero, SC; Gunzburg, MJ; Yap, M; Clayton, DJ; Del Borgo, MP; Perlmutter, P; Aguilar, MI; Shukla, GS; Peletskaya, E; Cookson, MM; Krag, DN; Wilce, MCJ; Wilce, JA,期刊：Journal of Molecular Biology, 页码：397-411 , 文章类型： Article，,卷期：2011年412-3] Growth-receptor-bound protein (Grb)7 is an adapter protein aberrantly overexpressed, along with the erbB-2 receptor in breast cancer and in other cancers. Normally recruited to focal adhesions with a role in cell migrati... Molecular Modeling and Functional Confirmation of a Predicted Fatty Acid Binding Site of Mitochondrial Aspartate Aminotransferase [作者：Bradbury, MW; Stump, D; Guarnieri, F; Berk, PD,期刊：Journal of Molecular Biology, 页码：412-422 , 文章类型： Article，,卷期：2011年412-3] Molecular interactions are necessary for proteins to perform their functions. The identification of a putative plasma membrane fatty acid transporter as mitochondrial aspartate aminotransferase (mAsp-AT) indicated that t... Drosophila BTB/POZ Domains of "ttk Group" Can Form Multimers and Selectively Interact with Each Other [作者：Bonchuk, A; Denisov, S; Georgiev, P; Maksimenko, O,期刊：Journal of Molecular Biology, 页码：423-436 , 文章类型： Article，,卷期：2011年412-3] The BTB (bric-a-brac, tramtrack and broad complex)/POZ (poxvirus and zinc finger) domain is a conserved protein-protein interaction motif contained in a variety of transcription factors involved in development, chromatin... Crystal Structure of the Archaeal Asparagine Synthetase: Interrelation with Aspartyl-tRNA and Asparaginyl-tRNA Synthetases [作者：Blaise, M; Frechin, M; Olieric, V; Charron, C; Sauter, C; Lorber, B; Roy, H; Kern, D,期刊：Journal of Molecular Biology, 页码：437-452 , 文章类型： Article，,卷期：2011年412-3] Asparagine synthetase A (AsnA) catalyzes asparagine synthesis using aspartate, ATP, and ammonia as substrates. Asparagine is formed in two steps: the beta-carboxylate group of aspartate is first activated by ATP to form ... Slow Formation of Stable Complexes during Coincubation of Minimal rRNA and Ribosomal Protein S4 [作者：Mayerle, M; Bellur, DL; Woodson, SA,期刊：Journal of Molecular Biology, 页码：453-465 , 文章类型： Article，,卷期：2011年412-3] Ribosomal protein 54 binds and stabilizes a five-helix junction or five-way junction (5WJ) in the 5' domain of 16S ribosomal RNA (rRNA) and is one of two proteins responsible for nucleating 30S ribosome assembly. Upon bi... Crystal Structure of alpha-Galactosidase from Lactobacillus acidophilus NCFM: Insight into Tetramer Formation and Substrate Binding [作者：Fredslund, F; Abou Hachem, M; Larsen, RJ; Sorensen, PG; Coutinho, PM; Lo Leggio, L; Svensson, B,期刊：Journal of Molecular Biology, 页码：466-480 , 文章类型： Article，,卷期：2011年412-3] Lactobacillus acidophilus NCFM is a probiotic bacterium known for its beneficial effects on human health. The importance of alpha-galactosidases (alpha-Gals) for growth of probiotic organisms on oligosaccharides of the r... Unique Utilization of a Phosphoprotein Phosphatase Fold by a Mammalian Phosphodiesterase Associated with WAGR Syndrome [作者：Dermol, U; Janardan, V; Tyagi, R; Visweswariah, SS; Podobnik, M,期刊：Journal of Molecular Biology, 页码：481-494 , 文章类型： Article，,卷期：2011年412-3] Metallophosphoesterase-domain-containing protein 2 (MPPED2) is a highly evolutionarily conserved protein with orthologs found from worms to humans. The human MPPED2 gene is found in a region of chromosome 11 that is dele... Structural Basis for Acyl Acceptor Specificity in the Achromobactin Biosynthetic Enzyme AcsD [作者：Schmelz, S; Botting, CH; Song, LJ; Kadi, NF; Challis, GL; Naismith, JH,期刊：Journal of Molecular Biology, 页码：495-504 , 文章类型： Article，,卷期：2011年412-3] Siderophores are known virulence factors, and their biosynthesis is a target for new antibacterial agents. A non-ribosomal peptide synthetase-independent siderophore biosynthetic pathway in Dickeya dadantii is responsibl...