- Local DNA Topography Correlates with Functional Noncoding Regions of the Human Genome
[作者:Parker, SCJ; Hansen, L; Abaan, HO; Tullius, TD; Margulies, EH,期刊:Science, 页码:389-392 , 文章类型: Article,,卷期:2009年324-5925]
- The three-dimensional molecular structure of DNA, specifically the shape of the backbone and grooves of genomic DNA, can be dramatically affected by nucleotide changes, which can cause differences in protein-binding affi...
- In Vivo Analysis of Dendritic Cell Development and Homeostasis
[作者:Liu, K; Victora, GD; Schwickert, TA; Guermonprez, P; Meredith, MM; Yao, KH; Chu, FF; Randolph, GJ; Rudensky, AY; Nussenzweig, M,期刊:Science, 页码:392-397 , 文章类型: Article,,卷期:2009年324-5925]
- Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates fro...
- A Contemporary Microbially Maintained Subglacial Ferrous "Ocean"
[作者:Mikucki, JA; Pearson, A; Johnston, DT; Turchyn, AV; Farquhar, J; Schrag, DP; Anbar, AD; Priscu, JC; Lee, PA,期刊:Science, 页码:397-400 , 文章类型: Article,,卷期:2009年324-5925]
- An active microbial assemblage cycles sulfur in a sulfate-rich, ancient marine brine beneath Taylor Glacier, an outlet glacier of the East Antarctic Ice Sheet, with Fe(III) serving as the terminal electron acceptor. Isot...
- Mirror Neurons Differentially Encode the Peripersonal and Extrapersonal Space of Monkeys
[作者:Caggiano, V; Fogassi, L; Rizzolatti, G; Thier, P; Casile, A,期刊:Science, 页码:403-406 , 文章类型: Article,,卷期:2009年324-5925]
- Actions performed by others may have different relevance for the observer, and thus lead to different behavioral responses, depending on the regions of space in which they are executed. We found that in rhesus monkeys, t...
- DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity
[作者:Meijsing, SH; Pufall, MA; So, AY; Bates, DL; Chen, L; Yamamoto, KR,期刊:Science, 页码:407-410 , 文章类型: Article,,卷期:2009年324-5925]
- Genes are not simply turned on or off, but instead their expression is fine-tuned to meet the needs of a cell. How genes are modulated so precisely is not well understood. The glucocorticoid receptor (GR) regulates targe...
- Comment on "Atmospheric Hydroxyl Radical Production from Electronically Excited NO2 and H2O"
[作者:Carr, S; Heard, DE; Blitz, MA,期刊:Science, 页码:U1-U2 , 文章类型: Editorial Material,,卷期:2009年324-5925]
- Li et al. (Reports, 21 March 2008, p. 1657) suggested that the reaction between electronically excited nitrogen dioxide and water vapor is an important atmospheric source of the hydroxyl radical. However, under condition...
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