- Prognostic and Predictive Significance of Plasma HGF and IL-8 in a Phase III Trial of Chemoradiation with or without Tirapazamine in Locoregionally Advanced Head and Neck Cancer
[作者:Le, QT; Fisher, R; Oliner, KS; Young, RJ; Cao, HC; Kong, C; Graves, E; Hicks, RJ; McArthur, GA; Peters, L; O'Sullivan, B; Giaccia, A; Rischin, D,期刊:Clinical Cancer Research, 页码:1798-1807 , 文章类型: Article,,卷期:2012年18-6]
- Purpose: Hepatocyte growth factor (HGF) is a hypoxia-induced secreted protein that binds to cMet and regulates interleukin (IL)-8 expression. We evaluated the role of circulating HGF and IL-8 as prognostic and predictive...
- IGFBP Ratio Confers Resistance to IGF Targeting and Correlates with Increased Invasion and Poor Outcome in Breast Tumors
[作者:Becker, MA; Hou, XN; Harrington, SC; Weroha, SJ; Gonzalez, SE; Jacob, KA; Carboni, JM; Gottardis, MM; Haluska, P,期刊:Clinical Cancer Research, 页码:1808-1817 , 文章类型: Article,,卷期:2012年18-6]
- Purpose: To improve the significance of insulin-like growth factor-binding protein 5 (IGFBP-5) as a prognostic and potentially predictive marker in patients with breast cancer. Experimental Design: Increased IGFBP-5 expr...
- Eribulin Mesylate for the Treatment of Patients with Refractory Metastatic Breast Cancer: Use of a "Physician's Choice" Control Arm in a Randomized Approval Trial
[作者:Donoghue, M; Lemery, SJ; Yuan, WS; He, K; Sridhara, R; Shord, S; Zhao, H; Marathe, A; Kotch, L; Jee, J; Wang, Y; Zhou, L; Adams, WM; Jarral, V; Pilaro, A; Lostritto, R; Gootenberg, JE; Keegan, P; Pazdur, R,期刊:Clinical Cancer Research, 页码:1496-1505 , 文章类型: Article,,卷期:2012年18-6]
- This work describes the considerations that led to the approval by the U. S. Food and Drug Administration (FDA), on November 15, 2010, of eribulin mesylate (Halaven; Eisai, Inc.) for the treatment of patients with refrac...
- Leveling the Playing Field: Bringing Development of Biomarkers and Molecular Diagnostics up to the Standards for Drug Development
[作者:Poste, G; Carbone, DP; Parkinson, DR; Verweij, J; Hewitt, SM; Jessup, JM,期刊:Clinical Cancer Research, 页码:1515-1523 , 文章类型: Article,,卷期:2012年18-6]
- Molecular diagnostics are becoming increasingly important in clinical research to stratify or identify molecularly profiled patient cohorts for targeted therapies, to modify the dose of a therapeutic, and to assess early...
- Development and Use of Integral Assays in Clinical Trials
[作者:Schilsky, RL; Doroshow, JH; LeBlanc, M; Conley, BA,期刊:Clinical Cancer Research, 页码:1540-1546 , 文章类型: Article,,卷期:2012年18-6]
- Clinical trials that include integral biomarkers to determine eligibility, assign treatment, or assess outcome must employ robust assays to measure the molecular analyte of interest. The decision to develop a biomarker a...
- Lessons Learned from the Investigational Device Exemption Review of Children's Oncology Group Trial AAML1031
[作者:Meshinchi, S; Hunger, SP; Aplenc, R; Adamson, PC; Jessup, JM,期刊:Clinical Cancer Research, 页码:1547-1554 , 文章类型: Review,,卷期:2012年18-6]
- The U.S. Food and Drug Administration is now exerting its regulatory authority over the use of molecular diagnostics and related assays for medical decision making in clinical trials, by performing pre-Investigational De...
- Biomarker Discovery, Development, and Implementation in France: A Report from the French National Cancer Institute and Cooperative Groups
[作者:Andre, F; Nowak, F; Arnedos, M; Lacroix, L; Viens, P; Calvo, F,期刊:Clinical Cancer Research, 页码:1555-1560 , 文章类型: Article,,卷期:2012年18-6]
- Biomarkers are increasingly changing the medical practice in oncology. One of the major challenges in the field of personalized medicine or biologically adapted therapies is to ensure a rapid and extensive implementation...
- The Fundamental Role of the p53 Pathway in Tumor Metabolism and Its Implication in Tumor Therapy
[作者:Shen, L; Sun, X; Fu, ZH; Yang, GD; Li, JY; Yao, LB,期刊:Clinical Cancer Research, 页码:1561-1567 , 文章类型: Review,,卷期:2012年18-6]
- It is well established that the altered metabolism exhibited by cancer cells, including high rates of glycolysis, lactate production, and biosynthesis of lipids, nucleotides, and other macromolecules, and which may occur...
- Expression of Interleukin-4 Receptor Alpha in Human Pleural Mesothelioma Is Associated with Poor Survival and Promotion of Tumor Inflammation
[作者:Burt, BM; Bader, A; Winter, D; Rodig, SJ; Bueno, R; Sugarbaker, DJ,期刊:Clinical Cancer Research, 页码:1568-1577 , 文章类型: Article,,卷期:2012年18-6]
- Purpose: The origin and pathogenesis of malignant pleural mesothelioma (MPM) are closely aligned with inflammation. MPM tumors express interleukin-4 receptor a (IL-4R alpha), the principal subunit of the IL-4 receptor. W...
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