- Coupling Molecular Dynamics Simulations with Experiments for the Rational Design of Indolicidin-Analogous Antimicrobial Peptides
[作者:Tsai, CW; Hsu, NY; Wang, CH; Lu, CY; Chang, Y; Tsai, HHG; Ruaan, RC,期刊:Journal of Molecular Biology, 页码:837-854 , 文章类型: Article,,卷期:2009年392-3]
- Antimicrobial peptides (AMPs) have attracted much interest in recent years because of their potential use as new-generation antibiotics. Indolicidin (IL) is a 13-residue cationic AMP that is effective against a broad spe...
- The LIM-Homeodomain Protein ISL1 Activates Insulin Gene Promoter Directly through Synergy with BETA2
[作者:Zhang, H; Wang, WP; Guo, T; Yang, JC; Chen, P; Ma, KT; Guan, YF; Zhou, CY,期刊:Journal of Molecular Biology, 页码:566-577 , 文章类型: Article,,卷期:2009年392-3]
- The LIM-homeodomain transcription factor ISM (islet factor 1) is essential for pancreatic islet cell and dorsal mesenchyme development. Mutations in ISL1 are associated with maturity-onset diabetes of the young and type ...
- E. coli Transports Aggregated Proteins to the Poles by a Specific and Energy-Dependent Process
[作者:Rokney, A; Shagan, M; Kessel, M; Smith, Y; Rosenshine, I; Oppenheim, AB,期刊:Journal of Molecular Biology, 页码:589-601 , 文章类型: Article,,卷期:2009年392-3]
- Aggregation of proteins due to failure of quality control mechanisms is deleterious to both eukaryotes and prokaryotes. We found that in Escherichia coli, protein aggregates are delivered to the pole and form a large pol...
- Functional Study of the P32T ITPA Variant Associated with Drug Sensitivity in Humans
[作者:Stepchenkova, EI; Tarakhovskaya, ER; Spitler, K; Frahm, C; Menezes, MR; Simone, PD; Kolar, C; Marky, LA; Borgstahl, GEO; Pavlov, YI,期刊:Journal of Molecular Biology, 页码:602-613 , 文章类型: Article,,卷期:2009年392-3]
- Sanitization of the cellular nucleotide pools from mutagenic base analogues is necessary for the accuracy of transcription and replication of genetic material and plays a substantial role in cancer prevention. The undesi...
- The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes
[作者:Kintzer, AF; Thoren, KL; Sterling, HJ; Dong, KC; Feld, GK; Tang, II; Zhang, TT; Williams, ER; Berger, JM; Krantz, BA,期刊:Journal of Molecular Biology, 页码:614-629 , 文章类型: Article,,卷期:2009年392-3]
- The assembly of bacterial toxins and virulence factors is critical to their function, but the regulation of assembly during infection has not been studied. We begin to address this question using anthrax toxin as a model...
- Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP Protein Family
[作者:Cossu, F; Milani, M; Mastrangelo, E; Vachette, P; Servida, F; Lecis, D; Canevari, G; Delia, D; Drago, C; Rizzo, V; Manzoni, L; Seneci, P; Scolastico, C; Bolognesi, M,期刊:Journal of Molecular Biology, 页码:630-644 , 文章类型: Article,,卷期:2009年392-3]
- XIAP is an apoptotic regulator protein that binds to the effector caspases -3 and -7 through its BIR2 domain, and to initiator caspase-9 through its BIR3 domain. Molecular docking studies suggested that Smac-DIABLO may a...
- X-ray Crystallographic Study of an HIV-1 Fusion Inhibitor with the gp41 S138A Substitution
[作者:Watabe, T; Terakawa, Y; Watanabe, K; Ohno, H; Nakano, H; Nakatsu, T; Kato, H; Izumi, K; Kodama, E; Matsuoka, M; Kitaura, K; Oishi, S; Fujii, N,期刊:Journal of Molecular Biology, 页码:657-665 , 文章类型: Article,,卷期:2009年392-3]
- The S138A substitution of fusion inhibitory peptides derived-from the C-terminal heptad repeat (C-HR) of the human immunodeficiency virus type 1 (HIV-1) gp41 leads to enhanced binding affinity to the N-terminal heptad re...
- (-)-Epigallocatechin-3-Gallate (EGCG) Maintains kappa-Casein in Its Pre-Fibrillar State without Redirecting Its Aggregation Pathway
[作者:Hudson, SA; Ecroyd, H; Dehle, FC; Musgrave, IF; Carver, JA,期刊:Journal of Molecular Biology, 页码:689-700 , 文章类型: Article,,卷期:2009年392-3]
- The polyphenol (-)-epigallocatechin-3-gallate (EGCG) has recently attracted much research interest in the field of protein-misfolding diseases because of its potent anti-amyloid activity against amyloid-beta, alpha-synuc...
- Archaeal aIF2B Interacts with Eukaryotic Translation Initiation Factors eIF2 alpha and eIF2B alpha: Implications for aIF2B Function and eIF2B Regulation
[作者:Dev, K; Santangelo, TJ; Rothenburg, S; Neculai, D; Dey, M; Sicheri, F; Dever, TE; Reeve, JN; Hinnebusch, AG,期刊:Journal of Molecular Biology, 页码:701-722 , 文章类型: Article,,卷期:2009年392-3]
- Translation initiation is down-regulated in eukaryotes by phosphorylation of the alpha-subunit of eIF2 (eukaryotic initiation factor 2), which inhibits its guanine nucleotide exchange factor, eIF2B. The N-terminal S1 dom...
- Interaction of the Dengue Virus Fusion Peptide with Membranes Assessed by NMR: The Essential Role of the Envelope Protein Trp101 for Membrane Fusion
[作者:Melo, MN; Sousa, FJR; Carneiro, FA; Castanho, MARB; Valente, AP; Almeida, FCL; Da Poian, AT; Mohana-Borges, R,期刊:Journal of Molecular Biology, 页码:736-746 , 文章类型: Article,,卷期:2009年392-3]
- Dengue virus (DV) infection depends on a step of membrane fusion, which occurs in the acidic environment of the endosome. This process is mediated by virus surface envelope glycoprotein, in which the loop between residue...
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