- Mitochondrial F1F0-ATP Synthase: The Small Subunits e and g Associate with Monomeric Complexes to Trigger Dimerization
[作者:Wagner, K; Rehling, P; Szklarz, LKS; Taylor, RD; Pfanner, N; van der Laan, M,期刊:Journal of Molecular Biology, 页码:855-861 , 文章类型: Article,,卷期:2009年392-4]
- Mitochondrial F1F0-ATP synthase catalyzes the formation of ATP from ADP and inorganic phosphate. The enzyme is found in monomeric, dimeric and higher oligomeric forms in the inner mitochondrial membrane. Dimerization of ...
- Imaging Amyloid Fibrils within Cells Using a Se-Labelling Strategy
[作者:Porter, AE; Knowles, TPJ; Muller, K; Meehan, S; McGuire, E; Skepper, J; Welland, ME; Dobson, CM,期刊:Journal of Molecular Biology, 页码:868-871 , 文章类型: Article,,卷期:2009年392-4]
- The process of aggregation leading to amyloid formation by peptides and proteins is associated with diseases ranging from systemic amyloidoses to neurodegenerative disorders such as Alzheimer's disease. A key question in...
- Polarized DNA Ejection from the Herpesvirus Capsid
[作者:Newcomb, WW; Cockrell, SK; Homa, FL; Brown, JC,期刊:Journal of Molecular Biology, 页码:885-894 , 文章类型: Article,,卷期:2009年392-4]
- Ejection of DNA from the capsid is an early step in infection by all herpesviruses. Ejection or DNA uncoating occurs after a parental capsid has entered the host cell cytoplasm, migrated to the nucleus, and bound to a nu...
- Structure-Function Studies of a Melanocarpus albomyces Laccase Suggest a Pathway for Oxidation of Phenolic Compounds
[作者:Kallio, JP; Auer, S; Janis, J; Andberg, M; Kruus, K; Rouvinen, J; Koivula, A; Hakulinen, N,期刊:Journal of Molecular Biology, 页码:895-909 , 文章类型: Article,,卷期:2009年392-4]
- Melanocarpus albomyces laccase crystals were soaked with 2,6-dimethoxyphenol, a common laccase substrate. Three complex structures from different soaking times were solved. Crystal structures revealed the binding of the ...
- Structural-Thermodynamic Relationships of Interactions in the N-Terminal ATP-Binding Domain of Hsp90
[作者:Nilapwar, S; Williams, E; Fu, C; Prodromou, C; Pearl, LH; Williams, MA; Ladbury, JE,期刊:Journal of Molecular Biology, 页码:923-936 , 文章类型: Article,,卷期:2009年392-4]
- Despite its importance as a target in anti-cancer therapeutics and the numerous rational-based inhibitor design efforts aimed at it, there are only limited data available on structural-thermodynamic relationships of inte...
- Biochemical and Structural Study of the Homologues of the Thiol-Disulfide Oxidoreductase DsbA in Neisseria meningitidis
[作者:Lafaye, C; Iwema, T; Carpentier, P; Jullian-Binard, C; Kroll, JS; Collet, JF; Serre, L,期刊:Journal of Molecular Biology, 页码:952-966 , 文章类型: Article,,卷期:2009年392-4]
- Bacterial virulence depends on the correct folding of surface-exposed proteins, a process catalyzed by the thiol-disulfide oxidoreductase DsbA, which facilitates the synthesis of disulfide bonds in Gram-negative bacteria...
- Molecular Mechanism of Inward Rectifier Potassium Channel 2.3 Regulation by Tax-Interacting Protein-1
[作者:Yan, XJ; Zhou, H; Zhang, JX; Shi, CW; Xie, XQ; Wu, YN; Tian, CL; Shen, YQ; Long, JF,期刊:Journal of Molecular Biology, 页码:967-976 , 文章类型: Article,,卷期:2009年392-4]
- Inwardly rectifying potassium channel 2.3 (Kir2.3) is specifically targeted on the basolateral membranes of epithelial and neuronal cells, and it thus plays an important role in maintaining potassium homeostasis. Tax-int...
- Structure and Cleavage Specificity of the Chymotrypsin-Like Serine Protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)
[作者:Tian, XS; Lu, GW; Gao, F; Peng, H; Feng, YJ; Ma, GP; Bartlam, M; Tian, KG; Yan, JH; Hilgenfeld, R; Gao, GF,期刊:Journal of Molecular Biology, 页码:977-993 , 文章类型: Article,,卷期:2009年392-4]
- Biogenesis and replication of the porcine reproductive and respiratory syndrome virus (PRRSV) include the crucial step of replicative polyprotein processing by self-encoded proteases. Whole genome bioinformatics analysis...
- Asparaginyl beta-Hydroxylation of Proteins Containing Ankyrin Repeat Domains Influences Their Stability and Function
[作者:Hardy, AP; Prokes, I; Kelly, L; Campbell, ID; Schofield, CJ,期刊:Journal of Molecular Biology, 页码:994-1006 , 文章类型: Article,,卷期:2009年392-4]
- Recent reports have provided evidence that the beta-hydroxylation of conserved asparaginyl residues in ankyrin repeat domain (ARD) proteins is a common posttranslational modification in animal cells. Here, nuclear magnet...
- Residual Structures in the Acid-Unfolded States of V lambda 6 Proteins Affect Amyloid Fibrillation
[作者:Mishima, T; Ohkuri, T; Monji, A; Kanemaru, T; Abe, Y; Ueda, T,期刊:Journal of Molecular Biology, 页码:1033-1043 , 文章类型: Article,,卷期:2009年392-4]
- Many proteins form amyloid-like fibrils in vitro under partially or highly unfolding conditions. Recently, we showed that the residual structure in highly unfolded state is closely related to amyloid fibril formation in ...
|