- Structural and Functional Diversity of Novel Coronin 1C (CRN2) Isoforms in Muscle
[作者:Xavier, CP; Rastetter, RH; Stumpf, M; Rosentreter, A; Muller, R; Reimann, J; Cornfine, S; Linder, S; van Vliet, V; Hofmann, A; Morgan, RO; Fernandez, MP; Schroder, R; Noegel, AA; Clemen, CS,期刊:Journal of Molecular Biology, 页码:287-299 , 文章类型: Article,,卷期:2009年393-2]
- Coronin 1C (synonyms: coronin-3, CRN2), a WD40 repeat-containing protein involved in cellular actin dynamics, is ubiquitously expressed in human tissues. Here, we report on the identification and functional characterizat...
- Product Release Rather than Chelation Determines Metal Specificity for Ferrochelatase
[作者:Medlock, AE; Carter, M; Dailey, TA; Dailey, HA; Lanzilotta, WN,期刊:Journal of Molecular Biology, 页码:308-319 , 文章类型: Article,,卷期:2009年393-2]
- Ferrochelatase (protoheme ferrolyase, E.C. 4.99.1.1) is the terminal enzyme in heme biosynthesis and catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX (heme). Within the past two years, ...
- Voltage- and pH-Dependent Changes in Vectoriality of Photocurrents Mediated by Wild-type and Mutant Proteorhodopsins upon Expression in Xenopus Oocytes
[作者:Lorinczi, E; Verhoefen, MK; Wachtveitl, J; Woerner, AC; Glaubitz, C; Engelhard, M; Bamberg, E; Friedrich, T,期刊:Journal of Molecular Biology, 页码:320-341 , 文章类型: Article,,卷期:2009年393-2]
- Proteorhodopsin (PR), a light-driven proton pump from marine proteobacteria, exhibits photocycle characteristics similar to bacteriorhodopsin (BR) at neutral PH, including an M-like photointermediate. However, at acidic ...
- Crystal Structure of the Membrane Fusion Protein CusB from Escherichia coli
[作者:Su, CC; Yang, F; Long, F; Reyon, D; Routh, MD; Kuo, DW; Mokhtari, AK; Van Ornam, JD; Rabe, KL; Hoy, JA; Lee, YJ; Rajashankar, KR; Yu, EW,期刊:Journal of Molecular Biology, 页码:342-355 , 文章类型: Article,,卷期:2009年393-2]
Gram-negative bacteria, such as Escherichia coli, frequently utilize tripartite efflux complexes belonging to the resistance-nodulation-division family to expel diverse toxic compounds from the cell. These systems con...
- Systematic Analysis of the Twin Cx(9)C Protein Family
[作者:Longen, S; Bien, M; Bihlmaier, K; Kloeppel, C; Kauff, F; Hammermeister, M; Westermann, B; Herrmann, JM; Riemer, J,期刊:Journal of Molecular Biology, 页码:356-368 , 文章类型: Article,,卷期:2009年393-2]
- The Mia40-Erv1 disulfide relay system is of high importance for mitochondrial biogenesis. Most so far identified substrates of this machinery contain either two cysteine-x(3)-cysteine (twin Cx(3)C) or two cysteine-x(9)-c...
- Crystal Structure of the Three Tandem FF Domains of the Transcription Elongation Regulator CA150
[作者:Lu, M; Yang, J; Ren, ZY; Sabui, S; Espejo, A; Bedford, MT; Jacobson, RH; Jeruzalmi, D; McMurray, JS; Chen, XM,期刊:Journal of Molecular Biology, 页码:397-408 , 文章类型: Article,,卷期:2009年393-2]
FF domains are small protein-protein interaction modules that have two flanking conserved phenylalanine residues. They are present in proteins involved in transcription, RNA splicing, and signal transduction, and ofte...
- Structural Studies of FF Domains of the Transcription Factor CA150 Provide Insights into the Organization of FF Domain Tandem Arrays
[作者:Murphy, JM; Hansen, DF; Wiesner, S; Muhandiram, DR; Borg, M; Smith, MJ; Sicheri, F; Kay, LE; Forman-Kay, JD; Pawson, T,期刊:Journal of Molecular Biology, 页码:409-424 , 文章类型: Article,,卷期:2009年393-2]
- FF domains are poorly understood protein interaction modules that are present within eukaryotic transcription factors, such as CA150 (TCERG-1). The CA150 FF domains have been shown to mediate interactions with the phosph...
- A Mechanism for Histone Chaperoning Activity of Nucleoplasmin: Thermodynamic and Structural Models
[作者:Taneva, SG; Banuelos, S; Falces, J; Arregi, I; Muga, A; Konarev, PV; Svergun, DI; Velazquez-Campoy, A; Urbaneja, MA,期刊:Journal of Molecular Biology, 页码:448-463 , 文章类型: Article,,卷期:2009年393-2]
- Nucleoplasmin (NP), a histone chaperone, acts as a reservoir for histones H2A-H2B in Xenopus laevis eggs and can displace sperm nuclear basic proteins and linker histones from the chromatin fiber of sperm and quiescent s...
- Structural and Kinetic Studies of the Allosteric Transition in Sulfolobus solfataricus Uracil Phosphoribosyltransferase: Permanent Activation by Engineering of the C-Terminus
[作者:Christoffersen, S; Kadziola, A; Johansson, E; Rasmussen, M; Willemoes, M; Jensen, KF,期刊:Journal of Molecular Biology, 页码:464-477 , 文章类型: Article,,卷期:2009年393-2]
- Uracil phosphoribosyltransferase catalyzes the conversion of 5-phosphoribosyl-alpha-1-diphosphate (PRPP) and uracil to uridine monophosphate (UMP) and diphosphate (PPi). The tetrameric enzyme from Sulfolobus solfataricus...
- Structural and Functional Characterization of the NHR1 Domain of the Drosophila Neuralized E3 Ligase in the Notch Signaling Pathway
[作者:He, FH; Salto, K; Kobayashi, N; Harada, T; Watanabe, S; Kigawa, T; Guntert, P; Ohara, O; Tanaka, A; Unzai, S; Muto, Y; Yokoyama, S,期刊:Journal of Molecular Biology, 页码:478-495 , 文章类型: Article,,卷期:2009年393-2]
- The Notch signaling pathway is critical for many developmental processes and requires complex trafficking of both Notch receptor and its ligands, Delta and Serrate. In Drosophila melanogaster, the endocytosis of Delta in...
- Structural Substrate Conditions Required for Neutral Endopeptidase-Mediated Natriuretic Peptide Degradation
[作者:Pankow, K; Schwiebs, A; Becker, M; Siems, WE; Krause, G; Walther, T,期刊:Journal of Molecular Biology, 页码:496-503 , 文章类型: Article,,卷期:2009年393-2]
- Natriuretic peptides are cyclic vasoactive peptide hormones with great diagnostic and therapeutic relevance. The main catabolic pathway postulated for natriuretic peptides is the degradation by neutral endopeptidase (NEP...
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